Product apis-apoptosis

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Catalog	name	Description	price
R-R-1784	Ganoderic acid D CAS No.108340-60-9	Ganoderic acid D/CAS No.108340-60-9, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells. Ganoderic acid D induces HeLa human cervical carcinoma apoptosis.	price>
R-R-1785	m-3M3FBS CAS No.200933-14-8	m-3M3FBS/CAS No.200933-14-8 is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis.	price>
R-R-1786	Prinaberel CAS No.524684-52-4	Prinaberel (ERB-041)/CAS No.524684-52-4 is a potent and selective estrogen receptor (ER) β agonist with IC50s of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. Prinaberel displays >200-fold selectivity for ERβ over ERα. Prinaberel is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. Prinaberel induces ovarian cancer apoptosis.	price>
R-R-1787	MYCMI-6 CAS No.681282-09-7	MYCMI-6 (NSC354961)/CAS No.681282-09-7 is a potent and selective endogenous MYC:MAX protein interactions inhibitor. MYCMI-6 blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with a Kd of 1.6 μM. MYCMI-6 inhibits tumor cell growth in a MYC-dependent manner (IC50<0.5 μM). MYCMI-6 is not cytotoxic to normal human cells. MYCMI-6 induces apoptosis.	price>
R-R-1788	Taccalonolide A CAS No.108885-68-3	Taccalonolide A/CAS No.108885-68-3 is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells.	price>
R-R-1789	Piceatannol CAS No.10083-24-6	Piceatannol/CAS No.10083-24-6 is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI). Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties. Piceatannol induces apoptosis in DLBCL cell lines. Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells.	price>
R-R-1790	Notoginsenoside R2 CAS No.80418-25-3	Notoginsenoside R2/CAS No.80418-25-3 is a newly isolated notoginsenoside from Panax notoginseng, showed neuroprotective effects against 6-OHDA-induced oxidative stress and apoptosis.	price>
R-R-1791	Prosapogenin A CAS No.19057-67-1	Prosapogenin A/CAS No.19057-67-1, a natural product from Veratrum, induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis.	price>
R-R-1792	Galgravin CAS No.528-63-2	Galgravin/CAS No.528-63-2 is an active compound in Nectandra megapotamica, with anti-inflammatory activity. Galgravin displays in vitro cytotoxic activity and induce apoptosis in leukemia cells.	price>
R-R-1793	Demethoxycurcumin CAS No.22608-11-3	Demethoxycurcumin(Curcumin II)/CAS No.22608-11-3 is a major active curcuminoid; possess anti-inflammatory properties; also exert cytotoxic effects in human cancer cells via induction of apoptosis.	price>

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