Product apis-apoptosis

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Catalog	name	Description	price
R-R-1856	Indibulin CAS No.204205-90-3	Indibulin (ZIO 301)/CAS No.204205-90-3, an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis.	price>
R-R-1857	Mepazine CAS No.60-89-9	Mepazine (Pecazine)/CAS No.60-89-9 is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine affects viability of ABC-DLBCL cells by enhancing apoptosis.	price>
R-R-1858	Gemcitabine-13C,15N2 hydrochloride CAS No.2757566-59-7	Gemcitabine-13C,15N2 (hydrochloride)/CAS No.2757566-59-7 is the 13C and 15N labeled Gemcitabine hydrochloride. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.	price>
R-R-1859	Mepazine hydrochloride CAS No.2975-36-2	Mepazine hydrochloride (Pecazine hydrochloride)/CAS No.2975-36-2 is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis.	price>
R-R-1860	Bufarenogin CAS No.17008-65-0	Bufarenogin/CAS No.17008-65-0 induces intrinsic apoptosis via Bax and ANT cooperation.	price>
R-R-1861	Taltobulin CAS No.228266-40-8	Taltobulin (HTI-286)/CAS No.228266-40-8, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis.	price>
R-R-1862	Taltobulin hydrochloride	Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin hydrochloride inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis.	price>
R-R-1863	Taltobulin trifluoroacetate CAS No.228266-41-9	Taltobulin trifluoroacetate (HTI-286 trifluoroacetate)/CAS No.228266-41-9, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin trifluoroacetate inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis.	price>
R-R-1864	Pladienolide B CAS No.445493-23-2	Pladienolide B/CAS No.445493-23-2 is a potent cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome. Pladienolide B exerts antitumor activities mediated through the inhibition of pre-mRNA splicing. Pladienolide B induces apoptosis.	price>
R-R-1865	Milademetan CAS No.1398568-47-2	Mliademetan (DS-3032)/CAS No.1398568-47-2 is an MDM2 inhibitor that is specific and oral for acute myeloid leukemia (AML) research.	price>

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