Product apis-apoptosis

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Catalog	name	Description	price
R-R-1732	Robinin CAS No.301-19-9	Robinin/CAS No.301-19-9 is a flavonoid that can be extracted from the leaves of purple cowpea, inhibiting TGF-β, TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin exerts anti-inflammatory and anti-tumor effects. The combination of Robinin and Methotrexate (HY-14519) reduces inflammation in experimental arthritis, Robinin can decrease the Doxorubicin (HY-15142A) induced cardiac toxicity effect.	price>
R-R-1733	Solamargine CAS No.20311-51-7	Solamargine/CAS No.20311-51-7, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity.	price>
R-R-1734	Bendamustine hydrochloride CAS No.3543-75-7	Bendamustine hydrochloride (SDX-105)/CAS No.3543-75-7, a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties.	price>
R-R-1735	Pivanex CAS No.122110-53-6	Pivanex (AN-9)/CAS No.122110-53-6, a derivative of Butyric acid, is an orally active HDAC inhibitor. Pivanex down-regulates bcr-abl protein and enhances apoptosis. Pivanex has antimetastic and antiangiogenic properties.	price>
R-R-1736	Iberin CAS No.505-44-2	Iberin (NSC 321801)/CAS No.505-44-2, a sulfoxide analogue of sulforaphane, is a naturally occurring member of isothiocyanate family. Iberin inhibits cell survival with an IC50 of 2.3 μM in HL60 cell. Iberin induces apoptosis.	price>
R-R-1737	MPT0B014 CAS No.1215208-59-5	MPT0B014/CAS No.1215208-59-5 is a tubulin polymerization inhibitor. MPT0B014 induces cancer cell apoptosis. MPT0B014 can be used for the research of cancer.	price>
R-R-1738	Bufotalin CAS No.471-95-4	Bufotalin/CAS No.471-95-4 is a steroid lactone isolated from Venenum Bufonis with potently antitumor activities. Bufotalin induces cancer cell apoptosis and also induces endoplasmic reticulum (ER) stress activation.	price>
R-R-1739	Ginsenoside F4 CAS No.181225-33-2	Ginsenoside F4 (GF4)/CAS No.181225-33-2, ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis. Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues.	price>
R-R-1740	MPT0B392 CAS No.1346169-92-3	MPT0B392/CAS No.1346169-92-3, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line.	price>
R-R-1741	Zotatifin CAS No.2098191-53-6	Zotatifin (eFT226)/CAS No.2098191-53-6 is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM). Zotatifin induces cell apoptosis.	price>

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