Product apis-apoptosis

Home > products > apis> apoptosis

Catalog	name	Description	price
R-R-1742	Xevinapant hydrochloride CAS No.1071992-57-8	Xevinapant (AT-406) hydrochloride/CAS No.1071992-57-8 is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs). Xevinapant hydrochloride binds to XIAP, cIAP1, and cIAP2 proteins with Kis of 66.4, 1.9, and 5.1 nM, respectively. Xevinapant hydrochloride effectively antagonizes XIAP BIR3 protein in a cell-free functional assay, induces rapid degradation of cellular cIAP1 protein, and inhibits cancer cell growth in various human cancer cell lines. Xevinapant hydrochloride is highly effective in induction of apoptosis in xenograft tumors.	price>
R-R-1743	Barbadin CAS No.356568-70-2	Barbadin/CAS No.356568-70-2 is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC50 values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors. Barbadin can induce apoptosis.	price>
R-R-1744	Vorinostat-d5 CAS No.1132749-48-4	Vorinostat-d5 (SAHA-d5)/CAS No.1132749-48-4 is the deuterium labeled Vorinostat. Vorinostat (SAHA) is a potent and orally active pan-inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC7 (Class II) and HDAC11 (Class IV), with ID50 values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis. Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification.	price>
R-R-1745	(S)-Oxiracetam CAS No.88929-35-5	(S)-oxiracetam (S-ORC)/CAS No.88929-35-5 is an inhibitor targeting apoptosis. S-ORC reduces brain infarct size and lessens neurological dysfunction in middle cerebral artery occlusion/reperfusion (MCAO/R) models. S-ORC prevents neuronal apoptosis via activating PI3K/Akt/GSK3β signaling pathway via α7 nAChR after ischemic stroke. S-ORC can prevent neuronal death after ischemic stroke.	price>
R-R-1746	Dihydrokaempferol CAS No.480-20-6	Dihydrokaempferol/CAS No.480-20-6 is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic agents.	price>
R-R-1747	(-)-Irofulven CAS No.158440-71-2	(-)-Irofulven (MGI 114)/CAS No.158440-71-2, an Illudin S analog, is a DNA alkylating agent. (-)-Irofulven inhibits the replication of DNA, induces tumor cells apoptosis, and has potent antitumor activity.	price>
R-R-1748	Medicarpin CAS No.32383-76-9	Medicarpin/CAS No.32383-76-9 is a flavonoid isolated from Medicago sativa. Medicarpin induces apoptosis and overcome multidrug resistance in leukemia P388 cells by modulating P-gp-mediated efflux of agents.	price>
R-R-1749	Nemorosone CAS No.351416-47-2	Nemorosone/CAS No.351416-47-2 is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells.	price>
R-R-1750	b-Elemene CAS No.515-13-9	β-Elemene ((-)-β-Elemene; Levo-β-elemene)/CAS No.515-13-9 is isolated from natural plant Curcuma aromatica with an antitumor activity. β-Elemene can induce cell apoptosis.	price>
R-R-1751	Pifithrin-a hydrobromide CAS No.63208-82-2	Pifithrin-α hydrobromide/CAS No.63208-82-2 is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.	price>

...