Product apis-apoptosis

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Catalog	name	Description	price
R-R-1620	Niraparib hydrochloride CAS No.1038915-64-8	Niraparib hydrochloride (MK-4827 hydrochloride)/CAS No.1038915-64-8 is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib hydrochloride leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity.	price>
R-R-1621	Tamoxifen (Standard) CAS No.10540-29-1	Tamoxifen (Standard)/CAS No.10540-29-1 is the analytical standard of Tamoxifen. This product is intended for research and analytical applications. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse.	price>
R-R-1622	Genistein-d4 CAS No.187960-08-3	Genistein-d4/CAS No.187960-08-3 is the deuterium labeled Genistein. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.	price>
R-R-1623	Tomatine CAS No.17406-45-0	Tomatine/CAS No.17406-45-0 is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.). Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome activity.	price>
R-R-1624	Luxeptinib CAS No.1616428-23-9	Luxeptinib (CG-806)/CAS No.1616428-23-9 is an orally active, reversible, first-in-class, non-covalent and potent pan-FLT3/pan-BTK inhibitor. Luxeptinib induces cell cycle arrest, apoptosis or autophagy in acute myeloid leukemia cells.	price>
R-R-1625	PD184161 CAS No.212631-67-9	PD184161/CAS No.212631-67-9 is an orally active MEK inhibitor. PD184161 inhibits MEK activity (IC50=10-100 nM) in a time- and concentration-dependent manner. PD184161 inhibits cell proliferation and induces apoptosis. PD184161 produces depressive-like behavior.	price>
R-R-1626	Busulfan-d8 CAS No.116653-28-2	Busulfan-d8/CAS No.116653-28-2 is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent.	price>
R-R-1627	Kongensin A CAS No.885315-96-8	Kongensin A/CAS No.885315-96-8 is a natural product isolated from Croton kongensis. Kongensin A is an effective, covalent HSP90 inhibitor that blocks RIP3-dependent necroptosishas. Kongensin A is a potent necroptosis inhibitor and an apoptosis inducer. Kongensin A has potential anti-necroptosis and anti-inflammation applications.	price>
R-R-1628	Obacunone CAS No.751-03-1	Obacunone/CAS No.751-03-1 is a highly oxidized triterpenoid limonoid isolated from citrus plants. Obacunone exerts its anticancer effects by inducing apoptosis. Obacunone also protects retinal pigment epithelial (RPE) cells from ultraviolet (UV) radiation (UVR)-induced oxidative damage.	price>
R-R-1629	Furanodiene CAS No.19912-61-9	Furanodiene/CAS No.19912-61-9 is a natural terpenoid isolated from Rhizoma Curcumae. Furanodiene plays anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level.	price>

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