Product apis-apoptosis

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Catalog	name	Description	price
R-R-1630	Meisoindigo CAS No.97207-47-1	Meisoindigo (Dian III)/CAS No.97207-47-1, a derivative of Indirubin (HY-N0117), halts the cell cycle at the G0/G1 phase and induces apoptosis in primary acute myeloid leukemia (AML) cells. Meisoindigo exhibits high antitumor activity.	price>
R-R-1631	Nevanimibe hydrochloride CAS No.133825-81-7	Nevanimibe hydrochloride (PD-132301 hydrochloride)/CAS No.133825-81-7 is an acyl-coenzyme A that is orally active and selective: cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer.	price>
R-R-1632	SM-433 hydrochloride	SM-433 hydrochlorid, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 hydrochlorid exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM (patent WO2008128171A2).	price>
R-R-1633	Ankaflavin CAS No.50980-32-0	Ankaflavin/CAS No.50980-32-0, isolated from Monascus-Fermented red rice, is an orally active PPARγ agonist. Ankaflavin exhibits selective cytotoxic effect and induces cell death through apoptosis on cancer cells. Ankaflavin has anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects.	price>
R-R-1634	Kaempferol CAS No.520-18-3	Kaempferol (Kempferol)/CAS No.520-18-3, a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer.	price>
R-R-1635	Genistein (Standard) CAS No.446-72-0	Genistein (Standard)/CAS No.446-72-0 is the analytical standard of Genistein. This product is intended for research and analytical applications. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.	price>
R-R-1636	Niraparib tosylate CAS No.1038915-73-9	Niraparib tosylate (MK-4827 tosylate)/CAS No.1038915-73-9 is a PARP1 and PARP2 inhibitor that is highly potent and orally bioavailable with an IC50 of 3.8 and 2.1 nM, respectively. Niraparib tosylate causes inhibition of DNA damage repair, activates apoptosis and exhibits antitumor activity.	price>
R-R-1637	Cerulenin CAS No.17397-89-6	Cerulenin/CAS No.17397-89-6, a potent, natural inhibitor of fatty acid synthase (FASN), is an epoxide produced by the fungus Cephalosporium caeruleus. Cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis. Cerulenin has antifungal and antitumor activies.	price>
R-R-1638	Didesmethylrocaglamide CAS No.177262-30-5	Didesmethylrocaglamide/CAS No.177262-30-5, a derivative of Rocaglamide, is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. Didesmethylrocaglamide has potent growth-inhibitory activity with an IC50 of 5 nM. Didesmethylrocaglamide suppresses multiple growth-promoting signaling pathways and induces apoptosis in tumor cells. Antitumor activity.	price>
R-R-1639	RWJ-56110 dihydrochloride CAS No.2387505-58-8	RWJ-56110 dihydrochloride/CAS No.2387505-58-8 is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite selective relative to U46619 (HY-108566). RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell apoptosis.	price>

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