Product apis-apoptosis

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Catalog	name	Description	price
R-R-1600	Humulone CAS No.26472-41-3	Humulone (α-Lupulic acid)/CAS No.26472-41-3, a prenylated phloroglucinol derivative, is a potent cyclooxygenase-2 (COX-2) inhibitor. Humulone acts as a positive modulator of GABAA receptor at low micromolar concentrations. Humulone is an inhibitor of bone resorption. Humulone possesses antioxidant, anti-angiogenic and apoptosis-inducing properties.	price>
R-R-1601	Everolimus CAS No.159351-69-6	Everolimus (RAD001)/CAS No.159351-69-6, a rapamycin derivative, is a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to produce an immunosuppressive complex. Everolimus inhibits tumor cell proliferation and induces apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activity.	price>
R-R-1602	Lexibulin CAS No.917111-44-5	Lexibulin (CYT-997)/CAS No.917111-44-5 is a potent and orally active tubulin polymerisation inhibitor with IC50s of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo. Lexibulin induces cell apoptosis and induces mitochondrial ROS generation in GC cells.	price>
R-R-1603	Isosilybin A CAS No.142796-21-2	Isosilybin A/CAS No.142796-21-2, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity. Isosilybin A inhibits proliferation and induces G1 phase arrest and apoptosis in cancer cells, which activates apoptotic machinery in PCA cells via targeting Akt-NF-κB-androgen receptor (AR) axis.	price>
R-R-1604	Difopein TFA	Difopein (TFA), a specific and competitive inhibitor of 14-3-3 protein (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein (TFA) leads to induction of apoptosis and enhances the ability of cisplatin to kill cells.	price>
R-R-1605	Cucurbitacin B CAS No.6199-67-3	Cucurbitacin B/CAS No.6199-67-3 belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity.	price>
R-R-1606	Mimosine CAS No.500-44-7	Mimosine/CAS No.500-44-7, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity. Mimosine is a known chelator of Fe(III). Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells. Anti-cancer, antiinflammation.	price>
R-R-1607	Minodronic acid CAS No.180064-38-4	Minodronic acid (YM-529)/CAS No.180064-38-4 is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain.	price>
R-R-1608	Didocosahexaenoin CAS No.124538-05-2	Didocosahexaenoin/CAS No.124538-05-2, an omega-3 derivative, is a diglyceride of DHA and can be synthesised from DHA triglycerides. Didocosahexaenoin causes significant loss of mitochondrial membrane potential and induces ROS production. Didocosahexaenoin induces apoptosis. Didocosahexaenoin induces stronger cytotoxicity than DHA in human prostate carcinoma cells.	price>
R-R-1609	Ilexsaponin A CAS No.108524-93-2	Ilexsaponin A/CAS No.108524-93-2, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes.	price>

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