Product apis-apoptosis

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Catalog	name	Description	price
R-R-1589	4-Methyldaphnetin CAS No.2107-77-9	4-Methyldaphnetin/CAS No.2107-77-9 is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation.	price>
R-R-1590	Ponicidin CAS No.52617-37-5	Ponicidin (Rubescensine B)/CAS No.52617-37-5 is a diterpenoid derived from Rabdosia rubescens, and exhibits immunoregulatory, anti-inflammatory, anti-viral and anti-cancer activity. Ponicidin (Rubescensine B) induces apoptosis of gastric carcinoma cell, decreases the phosphorylation of JAK2 and STAT3, and shows no effect on protein levels of JAK2 and STAT3.	price>
R-R-1591	W-7 hydrochloride CAS No.61714-27-0	W-7 hydrochloride/CAS No.61714-27-0 is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 μM and 51 µM, respectively. W-7 hydrochloride induces apoptosis and has antitumor activity.	price>
R-R-1593	N-trans-Feruloyltyramine CAS No.66648-43-9	N-trans-Feruloyltyramine (N-feruloyltyramine)/CAS No.66648-43-9, an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H2O2-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research.	price>
R-R-1594	AMXT-1501 tetrahydrochloride	AMXT-1501 tetrahydrochloride is an orally active polyamine transport inhibitor. AMXT1501 blocks tumor growth in immunocompetent mice but not in athymic nude mice lacking T cells. Combination of DFMO and AMXT‐1501 induces caspase‐3 mediated apoptosis in NB cell lines.	price>
R-R-1595	Farudodstat CAS No.1035688-66-4	Farudodstat (ASLAN003)/CAS No.1035688-66-4 is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 35 nM for human DHODH enzyme. Farudodstat inhibits protein synthesis via activation of AP-1 transcription factors. Farudodstat induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice.	price>
R-R-1596	Nafamostat mesylate CAS No.82956-11-4	Nafamostat mesylate (FUT-175)/CAS No.82956-11-4, an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat mesylate has anticancer and antivirus effect. Nafamostat mesylate induce apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat mesylate can be used in the development of the pathological thickening of the arterial wall.	price>
R-R-1597	Rabeprazole CAS No.117976-89-3	Rabeprazole (LY307640)/CAS No.117976-89-3 is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux.	price>
R-R-1598	Epimedokoreanin B CAS No.161068-53-7	Epimedokoreanin B/CAS No.161068-53-7 is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation.	price>
R-R-1599	Eriocitrin CAS No.13463-28-0	Eriocitrin/CAS No.13463-28-0 is a flavonoid isolated from lemons that is a powerful antioxidant. Eriocitrin inhibits the proliferation of liver cancer cells by arresting the cell cycle in the S phase by upregulating p53, cyclin A, cyclin D3 and CDK6. Eriocitrin triggers apoptosis by activating intrinsic signaling pathways involving mitochondria.	price>

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