Product fluorescent-dyes-No-ROS-Rox-derivatives

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Catalog	name	Description	price
R-XASYS-00577	A-484954,cas:142557-61-7	A-484954(C13H15N5O3,289.3) is an ATP-competitive inhibitor of eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 420 nM).It reduces eEF-2K autophosphorylation in PC3, HeLa, H460, H1299, and MDA-MB-231 cancer cells when used at a concentration of 75μM.	price>
R-XASYS-00578	A-486,cas:1889279-16-6	A-486(C25H24F4N4O5,536.5) is an inhibitor of the histone acetyltransferase p300/CBP (IC50 = 60 nM).It decreases acetylated histone H3 lysine 27 (H3K27Ac), but not H3K9Ac, levels in PC3 cells in a concentration-dependent manner. A-485 reduces proliferation of non-small cell lung cancer (NSCLC), small cell lung cancer, triple-negative breast cancer, mantel cell lymphoma, multiple myeloma, non-Hodgkins, and acute myeloid leukemia cell lines.	price>
R-XASYS-00579	A-802715,cas:107767-58-8	A 802715(C16H26N4O3,322.4) is an anti-tumor agent that causes dose-dependent protection against lipopolysaccharide induced lethal shock. It counteracts tumor necrosis factor alpha toxicity. It may regulate cell growth and damage response in human cancer tumor cells.	price>
R-XASYS-00580	A-836339,cas:959746-77-1	A-836339(C16H26N2O2S,310.5) is a synthetic cannabinoid (CB) which has a higher affinity for the peripheral CB2 receptor (Ki = 0.64 nM) over the central CB1 receptor (Ki = 270 nM). It displays analgesic, anti-inflammatory, and anti-hyperalgesic effects in mice.	price>
R-XASYS-00581	A2AR antagonist 1,cas:443103-97-7	A2A receptor antagonist 1(C16H12FN5O,309.3) (CPI-444 analog) is an antagonist of both adenosine A2A receptor and A1 receptor with Ki values of 4 and 264 nM, respectively.	price>
R-XASYS-00582	A922500,cas:959122-11-3	A-922500(C26H24N2O4,428.5) is a potent orally active inhibitor of DGAT-1 activity, inhibiting both human and mouse forms of the enzymes with IC50 values of 7 and 24 nM, respectively.	price>
R-XASYS-00583	AA 861,cas:80809-81-0	AA-861 is an inhibitor of 5-lipoxygenase (5-LO; IC50 = 0.8 µM).It is greater than 100-fold selective for 5-LO over 12-LO and cyclooxygenase (COX). AA-861 inhibits the production of 5-HETE and leukotriene B4 induced by A23187 (Item No. 22030) with IC50 values of 0.03 and 0.08 µM, respectively, in isolated rat peritoneal macrophages.	price>
R-XASYS-00584	AA26-9,cas:1312782-34-5	AA26-8(C7H10N4O,166.2) is a pan-serine hydrolase inhibitor.It inhibits acylaminoacyl-peptide hydrolase (APEH), platelet-activating factor acetylhydrolase 2 (PAF-AH2),α/βhydrolase domain-containing protein 11 (ABHD11), lysophospholipase 1(LYPLA1), fatty acid amide hydrolase (FAAH), and neutral cholesterol ester hydrolase 1 (NCEH1) when used at a concentration of 1 µM.	price>
R-XASYS-00585	AAI101,cas:1001404-83-6	AAI-101(C11H14N4O5S,314.32), also known as Enmetazobactam, is a beta lactamase inhibitor potentially for the treatment of multi-drug resistant gram-negative bacterial infections.	price>
R-XASYS-00586	AB-MECA,cas:152918-26-8	AB-MECA(C18H21N7O4,399.4) is an adenosine A3 receptor agonist (Ki = 430.5 nM for the human receptor expressed in CHO cells).It inhibits LPS-induced TNF-α production in primary cultured human lung macrophages (pD2 = 6.9).AB-MECA increases contraction of isolated guinea pig trachea ex vivo when used at a concentration of 0.1μM and increases bronchoconstriction.	price>

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