A-486,cas:1889279-16-6

A-486(C25H24F4N4O5,536.5) is an inhibitor of the histone acetyltransferase p300/CBP (IC50 = 60 nM).It decreases acetylated histone H3 lysine 27 (H3K27Ac), but not H3K9Ac, levels in PC3 cells in a concentration-dependent manner. A-485 reduces proliferation of non-small cell lung cancer (NSCLC), small cell lung cancer, triple-negative breast cancer, mantel cell lymphoma, multiple myeloma, non-Hodgkins, and acute myeloid leukemia cell lines.

msds of (1R)-N-[(4-fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2,4-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-spiro[1H-indene-1,5-oxazolidine]-3-acetamide