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Catalog	name	Description	price
R-C-1392	VX745 CAS：209410-46-8	Neflamapimod,also known as VX-745,VRT-031745 and VD-31745, is highly potent and selective p38α inhibitor(IC50=10 nM).VX-745 blocks TNFα production in LPS-stimulated HWB in vitro(IC50=177 nM).VX-745 displays excellent enzyme activity and selectivity,has a favorable pharmacokinetic profile,and demonstrates good in vivo activity in models of inflammation.	price>
R-R-3092	Quetiapine CAS No.111974-69-7	Quetiapine (ICI204636)/CAS No.111974-69-7 is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects.	price>
R-C-1393	Nirogacestat (PF-03084014) CAS：1290543-63-3	Nirogacestat,also known as PF-03084014,is a potent and selective gamma secretase (GS)inhibitor with potential antitumor activity.PF-03084014 binds to GS, blocking proteolytic activation of Notch receptors.Nirogacestat enhances the Antitumor Effect of Docetaxel in Prostate Cancer.Nirogacestat enhances docetaxel-mediated tumor response and provides a rationale to explore GSIs as adjunct therapy in conjunction with docetaxel for men with CRPC(castration-resistant prostate cancer).	price>
R-R-3093	BW-723C86 CAS No.160521-72-2	BW-723C86/CAS No.160521-72-2 is a potent and a selective 5-HT2B receptor agonist. BW-723C86 exhibits anxiolytic-like actions. BW-723C86 also causes hyperphagia and reduced grooming in rats.	price>
R-C-1394	RO4938581 CAS：883093-10-5	RO 4938581 is a potent and selective GABAA α5 inverse agonist,with a Ki of 4.6 nM for GABAA α5β3γ2a,and shows a lower affinity at α1β3γ2a,α2β3γ2a, α3β3γ2a (Ki,174,185,80 nM,respectively).	price>
R-R-3094	Alprenolol hydrochloride CAS No.13707-88-5	Alprenolol ((RS)-Alprenolol; dl-Alprenolol) hydrochloride/CAS No.13707-88-5 is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol hydrochloride is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent.	price>
R-C-1395	ARQ621 CAS：1095253-39-6	ARQ-621 is an allosteric,potent and selective inhibitor of Eg5,a microtubule-based ATPase motor protein involved in cell division.Over-expression of Eg5 causes genomic instability and tumor formation in mice;therefore,Eg5 is a potential anti-cancer target.Preclinical data shows anti-tumor activity of ARQ 621 across a wide range of cell lines from human solid and hematological malignancies.	price>
R-R-3095	Vilazodone Hydrochloride CAS No.163521-08-2	Vilazodone Hydrochloride (EMD 68843 Hydrochloride)/CAS No.163521-08-2 is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist.	price>
R-C-1396	Glasdegib (PF-04449913) CAS：1095173-27-5	Glasdegib,also known as PF-04449913,is an orally bioavailable small-molecule inhibitor of the Hedgehog(Hh)signaling pathway with potential antineoplastic activity.Hedgehog inhibitor PF-04449913 appears to inhibit Hh pathway signaling. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair.Constitutive activation of Hh pathway signaling has been observed in various types of malignancies.	price>
R-R-3096	Pimavanserin CAS No.706779-91-1	Pimavanserin/CAS No.706779-91-1 is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.	price>
R-C-1397	Fludarabine (NSC 118218) CAS:21679-14-1	Fludarabine is an adenosine analong,DNA chain terminator,and inhibitor of ribonucleotide reductase,DNA ligase,DNA primase,and adenoside A1 receptors.It is use to treat leukemias and graft-versus host disease in transplant patients.It also induces cell cycle arrest and apoptosis in alloreactive bone marrow stromal cells.	price>
R-R-3097	SB 242084 CAS No.181632-25-7	SB 242084/CAS No.181632-25-7 is a selective, competitive and high-affinity (pKi=9.0) 5-HT2C receptor antagonist (crosses the blood-brain barrier). SB 242084 increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 also increases mitochondrial gene expression and oxidative metabolism via 5-HT2A receptor. SB 242084 has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage.	price>
R-C-1398	LY-2183240 CAS:874902-19-9	LY-2183240 is a potent,covalent inhibitor of the EC-degrading enzyme fatty acid amide hydrolase(FAAH).LY-2183240 disrupts the cellular uptake of the lipid endocannabinoid(EC)anandamide and promote analgesia in vivo.LY-2183240 is also an inhibitor of monoacylgylcerol lipase(MGL).	price>
R-R-3098	Nuciferine CAS No.475-83-2	Nuciferine/CAS No.475-83-2 is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.	price>
R-C-1399	ONO-7643 CAS:249921-19-5	Anamorelin(ONO-7643,RC-1291,ST-1291)is an orally active,high-affinity,selective agonist of the ghrelin receptor with an EC50 value of 0.74 nM in the HEK293/GRLN FLIPR assay.	price>
R-R-3099	Pindolol CAS No.13523-86-9	Pindolol (LB-46)/CAS No.13523-86-9 is a nonselective β-blocker with partial beta-adrenergic receptor agonist activity, also functions as a 5-HT1A receptor weak partial antagonist (Ki=33nM).	price>
R-C-1400	MK-7655 CAS:1174018-99-5	Relebactam, also known as MK-7655,a potent and selective β-lactamase inhibitor. At a concentration of 4 mg/L,MK-7655 reduced imipenem MICs for Enterobacteriaceae with KPC carbapenemases from 16-64 mg/L to 0.12-1 mg/L.MK-7655 potentiated imipenem against Enterobacteriaceae with KPC carbapenemases or combinations of β-lactamase and impermeability,but not those with metallo-carbapenemases.It augmented the activity of imipenem against P.aeruginosa in general and OprD mutants in particular.	price>
R-R-3100	Buspirone hydrochloride CAS No.33386-08-2	Buspirone hydrochloride/CAS No.33386-08-2 is a 5-HT1A receptor agonist. Buspirone hydrochloride can be used for anxiety and depression research.	price>
R-R-3101	GR 113808 CAS No.144625-51-4	GR 113808/CAS No.144625-51-4 is a potent and highly selective 5-HT4 receptor antagonist (pKb= 8.8). GR 113808 shows 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors.	price>
R-C-1402	ABT530 CAS:1353900-92-1	Pibrentasvir(ABT-530)is a novel and pan-genotypic hepatitis C virus(HCV) NS5A inhibitor with EC50 ranging from 1.4 pM to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6.	price>

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