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Catalog	name	Description	price
R-R-2745	VU0364770 hydrochloride CAS No.1414842-70-8	VU0364770 hydrochloride/CAS No.1414842-70-8 is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 hydrochloride exhibits EC50s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 hydrochloride exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 hydrochloride also possesses activity at MAO with Ki values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively.	price>
R-C-1046	Tofacinix CAS:477600-75-2	Tofacitinib is an orally available inhibitor of Janus kinases(JAK),with immunomodulatory and anti-inflammatory activities.Upon administration, tofacitinib binds to JAK and prevents the activation of the JAK-signal transducers and activators of transcription(STAT)signaling pathway.This may decrease the production of pro-inflammatory cytokines,such as interleukin (IL)-6,-7,-15,-21,interferon-alpha and -beta, and may prevent both an inflammator response and the inflammation-induced damage caused by certain immunological diseases.JAK kinases are intracellular enzymes involved in signaling pathways affecting hematopoiesis,immunity and inflammation.	price>
R-R-2746	mGluR3 modulator-1 CAS No.374548-18-2	mGluR3 modulator-1 (compound 3)/CAS No.374548-18-2 is a mGluR3 modulator, with an EC50 of 1-10 μM in HEK293T-mGluR-Gqi5 Calcium Mobilization Assay.	price>
R-C-1047	lurasidone CAS: 367514-87-2	Lurasidone(SM-13496)is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki=1nM and Ki=0.5 nM,respectively.It also has high affinity for serotonin 5-HT7 receptors(Ki=0.5 nM),partial agonist activity at 5-HT1A receptors(Ki=6.4 nM)and lacks affinity for histamine H1 and muscarinic M1 receptors.	price>
R-R-2747	AZD 2066 CAS No.934282-55-0	AZD 2066/CAS No.934282-55-0 is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066 has antinociception effects.	price>
R-C-1048	VS-4718(PND1186) CAS No. 1061353-68-1	PND-1186(VS-4718)is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM.PND-1186 selectively promotes tumor cell apoptosis.PND-1186 is an effective FAK inhibitor with IC50 of 1.5 nm.Pnd-1186 did not change the tyrosine phosphorylation of c-Src or p130cas,but inhibited cell movement.	price>
R-R-2748	L-Glutamine-5-13C CAS No.159680-32-7	L-Glutamine-5-13C/CAS No.159680-32-7 is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.	price>
R-C-1049	WH-4-023 cas: 837422-57-8	WH-4-023(KIN001-112,KIN112,Dual LCK/SRC inhibitor)is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively.Exhibits>300-fold selectivity against p38α and KDR.Also potently inhibits SIK(IC50 values are 10,22 and 60 nM for SIK 1,2 and 3 respectively)and displays selectivity over a range of closely related kinases.	price>
R-R-2749	AMN082 free base CAS No.83027-13-8	AMN082 free base/CAS No.83027-13-8, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 free base shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects.	price>
R-C-1050	Lasmiditan (COL-144; LY573144) CAS:439239-90-4	Lasmiditan is is a high-affinity,highly selective 5-HT1F receptor agonist (Ki=2.1nM),compared with Ki of 1043 nM and 1357 nM at the 5-HT(1B)and 5-HT(1D) receptors,respectively.	price>
R-R-2750	CPCCOEt CAS No.179067-99-3	CPCCOEt/CAS No.179067-99-3 is a low affinity, selective, non-competitive and reversible antagonist of metabotropic glutamate receptor 1b (mGluR1b).	price>
R-C-1051	A966492 CAS:934162-61-5	A-966492 displayed high potency against the poly(ADP-ribose)polymerase-1 (PARP-1)enzyme with a K(i)of 1 nM and an EC(50) of 1 nM in a whole cell assay.	price>
R-R-2751	AZD 2066 hydrate	AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066 hydrate has antinociception effects.	price>
R-C-1052	AMG-47a CAS No. 882663-88-9	AMG-47a is a potent,nonselective inhibitor of Lck kinase with IC50 of 3.4 uM and it also inhibits T cell proliferation.AMG-47a exhibit anti-inflammatory activity(ED50)of 11 mg/kg in the anti-CD3-induced production of interleukin-2 (IL-2)in mice.	price>
R-R-2752	DFMTI CAS No.864864-86-8	DFMTI/CAS No.864864-86-8 can completely block the rmGlu1 L757V glutamate response.	price>
R-C-1053	Tazemetostat (EPZ-6438) CAS No. 1403254-99-8	Tazemetostat(EPZ-6438,E7438)is a potent,and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays,exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs.	price>
R-R-2753	Mavoglurant racemate CAS No.1636881-61-2	Mavoglurant racemate (AFQ-056 racemate)/CAS No.1636881-61-2 is the racemate of Mavoglurant. Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist. Mavoglurant (racemate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1054	EPz005687 CAS:1396772-26-1	EPZ005687 is a potent and selective inhibitor of EZH2 with Ki of 24 nM,and has 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases.	price>
R-R-2754	VU6010572 CAS No.2126784-39-0	VU6010572/CAS No.2126784-39-0 is a potent and selective mGlu3 negative allosteric modulator with IC50 of 245 nM. VU6010572 is highly CNS penetrant.	price>
R-C-1055	4EGI-1 CAS:315706-13-9	4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM.4EGI-1 specifically inhibits the function of mTOR by blocking the activation of 4E-BP1.4EGI-1 induces apoptosis.	price>

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