Vandetanib (ZD6474) CAS No. 443913-73-3

Vandetanib(ZD6474)is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay.It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM,respectively.Not sensitive to PDGFRβ,Flt1,Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM.No activity against MEK,CDK2,c-Kit,erbB2,FAK,PDK1,Akt and IGF-1R with IC50 above 10 μM. Vandetanib(ZD6474)increases apoptosis and induces autophagy by increasing the level of reactive oxygen species(ROS).

msds---Vandetanib (ZD6474)