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Catalog	name	Description	price
R-C-1005	TAS-103 cas:174634-08-3	TAS-103 is a dual inhibitor of DNA topoisomerase I/II,used for cancer research.	price>
R-R-2705	(E/Z)-SIB-1893 CAS No.6266-99-5	(E/Z)-SIB-1893/CAS No.6266-99-5 is a racemic compound of (E)-SIB-1893 and (Z)-SIB-1893 isomers. (E)-SIB-1893 is a selective non-competitive metabotropic glutamate subtype 5 receptor (mGluR5) antagonist.	price>
R-C-1006	PF-04217903 cas:956905-27-4	PF-04217903(PF-4217903)is a novel ATP-competitive small molecule inhibitor of c-Met kinases with the IC50 values from 3.1 nM to 142 nM.PF-04217903(PF-4217903) demonstrated>1000 fold selectivity for c-Met compared with>150 kinases, making it one of the most selective c-Met inhibitors described to date.PF-04217903(PF-4217903)inhibited tumor cell proliferation,survival,migration/invasion in MET amplified cell lines in vitro,and demonstrated marked antitumor activity in tumor models harboring either MET gene amplification or a HGF/c-Met autocrine loop at well-tolerated dose levels in vivo.	price>
R-R-2706	VU-29 CAS No.890764-36-0	VU-29/CAS No.890764-36-0 is a positive allosteric modulator of metabotropic glutamate 5 (mGlu5) receptor (EC50=9 nM and Ki=244 nM for rmGluR5). VU-29 is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM).	price>
R-C-1007	K145 (hydrochloride) cas:1449240-68-9（HCl）	K145 hydrochloride accumulates in U937 cells,suppresses the S1P level, and inhibits SphK2 by using human leukemia U937 cells in vitro studies.K145 hydrochloride exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells,and that these effects may be through the inhibition of down-stream ERK and Akt signaling pathways.K145 hydrochloride significantly inhibited the growth of U937 tumors in nude mice by both intraperitoneal and oral administration,thus demonstrating its in vivo efficacy as a potential lead anticancer agent.The antitumor activity of K145 was also confirmed in a syngeneic mouse model by implanting murine breast cancer JC cells in BALB/c mice.	price>
R-R-2707	(RS)-APICA CAS No.170847-18-4	(RS)-APICA/CAS No.170847-18-4 is a selective group II metabotropic glutamate receptor (mGluR II) antagonist. (RS)-APICA shows potential neuroprotective effect.	price>
R-C-1008	PFI-1 (PF-6405761) cas:1403764-72-6	PFI-1(PF-6405761)is a highly selective BET(bromodomain-containing protein)inhibitor for BRD4 with IC50 of 0.22 μM and for BRD2 with IC50 of 98 nM in a cell-free assay.	price>
R-R-2708	Biphenylindanone A CAS No.866823-73-6	Biphenylindanone A (BINA)/CAS No.866823-73-6 is a selective human mGluR2 (hmGluR2) potentiator for the treatment of many neurological disorders.	price>
R-C-1009	GNZ-644282 cas:529488-28-6	Genz-644282 is a non-camptothecin topoisomerase I(Topo I)inhibitor that demonstrates potent cytotoxic activity with a median IC50 of 1.2 nM(range 0.2 nM-21.9 nM).Genz-644282 can be used in cancer research.	price>
R-R-2709	ABP688 CAS No.924298-51-1	ABP688/CAS No.924298-51-1 is a high affinity human mGluR5 antagonist with anKi of 1.7 nM. Radioisotope-labeled ABP688 can be used as a PET tracer for clinical imaging of the mGlu5 receptor.	price>
R-C-1010	CH5138303 cas:959763-06-5	CH5138303 is a triazine Hsp90 inhibitor.1 CH5138303 binds to the N-terminus of Hsp90α(Kd=0.52 nM)and inhibits growth of HCT116 and NCI-N87 human tumor cell lines in vitro(IC50s=89 and 66 nM,respectively).CH5138303 also inhibits growth of human NCI-N87 gastric cancer xenografts(ED50=3.9 mg/kg)and displays high oral bioavailability in mice.	price>
R-R-2710	FITM CAS No.932737-65-0	FITM/CAS No.932737-65-0 is a negative allosteric modulator of mGlu1 receptor with a Ki of 2.5 nM.	price>
R-C-1011	B-RAF cas:1093100-40-3	BRAF is a human gene that encodes a protein called B-Raf.The gene is also referred to as proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B,while the protein is more formally known as serine/threonine-protein kinase B-Raf.	price>
R-R-2711	LY456236 CAS No.338736-46-2	LY456236/CAS No.338736-46-2 is a selective, non-competitive and orally active mGlu1 receptor antagonist that inhibits phosphoinositide hydrolysis with an IC50 of 0.145 μM. LY456236 also inhibits EGFR with an IC50 of 0.91 μM.	price>
R-C-1012	Losmapimod(GW-856553) cas:585543-15-3	Losmapimod,also know as GW856553 or GW856553X,is a drug developed by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen-activated protein kinases.	price>
R-R-2712	Methoxy-PEPy CAS No.524924-76-3	Methoxy-PEPy/CAS No.524924-76-3 is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM.	price>
R-C-1013	AMG-706 CAS No. 857876-30-3	Motesanib Diphosphate(AMG 706 Diphosphate)is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50s of 2 nM/3 nM/6 nM,respectively,and has similar activity against Kit,and is approximately 10-fold more selective for VEGFR than PDGFR and Ret.	price>
R-R-2713	Pomaglumetad methionil hydrochloride CAS No.635318-26-2	Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride)/CAS No.635318-26-2 is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research.	price>
R-C-1014	TMP-269 cas:1314890-29-3	TMP 269 is a potent,selective class IIa HDAC inhibitor with IC50 of 157 nM,97 nM,43 nM and 23 nM for HDAC4,HDAC5,HDAC7 and HDAC9,respectively.	price>
R-R-2714	HTL14242 CAS No.1644645-32-8	HTL14242 (HTL0014242)/CAS No.1644645-32-8 is an advanced and orally active mGlu5 NAM with a pKi and a pIC50 of 9.3 and 9.2, respectively.	price>

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