CNX1351 cas:1276105-89-5

CNX-1351 is a covalent inhibitor of PI3Kα(IC50=6.8 nM).1 It is selective for PI3Kα over PI3Kβ,-γ,and-δ(IC50s=166,240.3,and 3,020 nM,respectively),as well as PI3KC2A,PI3KC,PI4Kα,PI4Kβ,SPHK1,and SPHK2 (IC50s=>1 µM for all).CNX-1351 (500 nM)inhibits phosphorylation of Akt in SKOV3 cells.It inhibits the growth of SKOV3 and MCF-7 cancer cells(GI50s=77.6 and 54.7 nM,respectively).CNX-1351(100 mg/kg)inhibits Akt phosphorylation in mouse spleen.

msds----CNX1351