Catalog name Description price
R-C-444 vx-702 VX-702 inhibits p38 MAPK, preventing p38 MAPK-dependent inflammatory cytokine release.VX-702 is in development to treat inflammation and cardiovascular diseases and currentlyshows mixed results in clinical trials as a potential treatment for rheumatoid arthritis.In vitro,Vx-702 decreases platelet lesioning in storage without affecting platelet function. price>
R-C-450 Selumetinib(AZD6244) CAS:606143-52-6 Selumetinib(AZD6244,ARRY-142886) is a potent, highly selective MEK inhibitor with IC50 of 14 nM for MEK1 and Kd value of 530 nM for MEK2.It also inhibits ERK1/2 phosphorylation with IC50 of 10 nM,no inhibition to p38α,MKK6,EGFR,ErbB2, ERK2,B-Raf,etc.Selumetinib suppresses cell proliferation,migration and trigger apoptosis.  price>
R-C-452 Trametinib(GSK1120212) CAS:871700-17-3 Trametinib (GSK1120212,JTP-74057, Mekinist)is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays,no inhibition of the kinase activities of c-Raf,B-Raf,ERK1/2.Trametinib activates autophagy and induces apoptosis. price>
R-C-499 RAF265 cas:927880-90-8 RAF265(CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM,and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM in cell-free assays.RAF265 (CHIR-265)induces cell cycle arrest and apoptosis.  price>
R-C-529 PD0325901 cas:391210-10-9 Mirdametinib(PD0325901) is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays,roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. price>
R-C-553 LDN-211904 CAS:1198408-39-7 A pyrazolo[1,5-a] pyridine derivative,as an effective and reversible inhibitor of EphB3 receptor tyrosine kinase,has good stability and water solubility in mouse liver microsomes with IC50 of 79 nm.EphB3 induced autophosphorylation of EphB3 receptor was inhibited in 10 μ M cells. price>
R-C-560 SB203580 cas:152121-47-6 SB203580(RWJ 64809)is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively.SB 203580 inhibits LCK,GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38.SB 203580 does not disrupt JNK activity and is an autophagy and mitophagy activator. price>
R-C-610 PLX4720 cas:918505-84-7 PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay,equally potent to c-Raf-1(Y340D and Y341D mutations),10-fold selectivity for B-RafV600E than wild-type B-Raf. price>
R-C-641 PD169316 cas:152121-53-4 PD 169316 is a potent,cell-permeable and selective p38 MAP kinase inhibitor, with IC50 of 89 nM.PD169316 selectively inhibits the kinase activity of the phosphorylated p38 without hindering upstream kinases to phosphorylate p38. PD169316 shows antiviral activity against Enterovirus71.PD169316 shows antiviral activity against Enterovirus71. price>
R-C-643 BIX02188 CAS:1094614-84-2 BIX02188 is a potent MEK5-selective inhibitor with an IC50 of 4.3 nM.BIX02188 inhibits ERK5 catalytic activity,with an IC50 of 810 nM. price>