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Catalog	name	Description	price
R-C-1239	R1487 Hydrochloride CAS:449808-64-4	R1487 Hydrochloride is a highly potent and selective p38αinhibitor, with Kd values of 0.2 nM and 29 nM for p38α and p38β,respectively.	price>
R-C-1241	Cobimetinib(gdc0973,XL518,RG7420) CAS No. 934660-93-2	Cobimetinib (GDC-0973,RG7420)is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM,showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.Cobimetinib induces apoptosis.	price>
R-C-1269	L-779450 CAS： 303727-31-3	L-779450 is a potent,selective and ATP-competitive Raf kinase inhibitor(IC50=10 nM).L-779450 suppresses DNA synthesis and induces apoptosis in cells that proliferate in response to Raf-1 and A-Raf but not B-Raf.	price>
R-C-1292	Vacquinol-1 CAS# 5428-80-8	Vacquinol-1,also known as NSC 13316,is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells.Vacquinol-1 has beneficial effects on a glioblastoma multiforme mouse model by oral administration.In glioblastoma cells,Vacquinol-1 targets macropinocytosis,a cellular process that will not lead to cell death in normal cells.	price>
R-C-1340	SB202190 (FHPI) CAS：152121-30-7	SB202190(FHPI)is a potent p38 MAPK inhibitor targeting p38α/β with IC50 of 50 nM/100 nM in cell-free assays,sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo.SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1.SB202190 significantly suppresses Erastin‐dependent ferroptosis.	price>
R-C-1392	VX745 CAS：209410-46-8	Neflamapimod,also known as VX-745,VRT-031745 and VD-31745, is highly potent and selective p38α inhibitor(IC50=10 nM).VX-745 blocks TNFα production in LPS-stimulated HWB in vitro(IC50=177 nM).VX-745 displays excellent enzyme activity and selectivity,has a favorable pharmacokinetic profile,and demonstrates good in vivo activity in models of inflammation.	price>
R-C-1428	GW5074 CAS:220904-83-6	GW 5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM,and has no effect on the activities of JNK1/2/3,MEK1,MKK6/7,CDK1/2,c-Src,p38 MAP,VEGFR2 or c-Fms.	price>
R-C-1465	TA 02 CAS: 1784751-19-4	TA-02,an analog of SB 203580(HY-10256),is a p38 MAPK inhibitor with an IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.TA-02 exhibits similar cardiogenic properties as SB 203580 and SB 202190(HY-10295).	price>
R-C-1471	MLN2480 CAS:1096708-71-2	MLN2480(BIIB-024,TAK580,AMG-2112819,BSK1369,DAY-101)is an oral,selective pan-Raf kinase inhibitor in chinical trials.	price>
R-C-1488	U0126-EtOH CAS：1173097-76-1	U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays,100-fold higher affinity for N3-S218E/S222D MEK than PD98059.U0126 inhibits autophagy and mitophagy with antiviral activity.	price>

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