Product supramolecular-chemistry-macrocyclic-ligand

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Catalog	name	Description	price
R-R-0009	Gancaonin O,CAS:129145-53-5	Gancaonin O/CAS:129145-53-5/2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-(3-methylpent-2-enyl)chromen-4-one. Gancaonin O is a death ligand that binds to the death receptor on macrophages and induces apoptosis. Gancaonin O has been shown to induce programmed cell death in lung cancer cells by interfering with the PI3K/AKT signaling pathway. This drug also interacts with the M2 macrophage phenotype, which is associated with tumor suppression and immune regulation. Gancaonin O is currently being evaluated as a potential therapeutic agent for lung cancer.	price>
R-C07731	DOTA NHS ester,CAS#:170908-81-3	DOTA NHS ester,CAS#:170908-81-3	price>
R-R-0018	GD-DOTA	Gd-DOTA/Gadolinium dota/Dotarem. Ionic macrocyclic gadolinium complex of DOTA designed for MRI imaging. Its parametric proprieties increase contrast enhancement in MRI. Freely excreted by the kidneys and very inert biologically.	price>
R-H-33001	Tetrazine-NOTA	Tetrazine-NOTA	price>
R-L-046	Eu-DTPA	Eu-DTPA from ruixi.Amino polycarboxylic acid compounds are used as ligands. According to the chemical properties and structural composition of food additives, and with reference to the DNA/RNA single-chain base sequencing rules, the base or base analogues that can recognize the analyte are selected to modify the ligands. React with metal ions to synthesize a new type of rare earth amino polycarboxylic acid pin complexes, which are used as fluorescent probes to detect certain food additives.	price>
R-L-047	Gd-DTPA-BMA	Gd-DTPA-BMA from ruixi.DTPA-BMA is a derivative of DTPA, which retains three anionic carboxyl groups. The carboxyl groups at positions 1 and 4 are replaced by 2-methylamide (- CONHCH3) respectively. After forming a chelate with Gd, DTPA-BMA will become neutral without charge.	price>
R-R-0200	Phytanic Acid CAS 14721-66-5	Phytanic acid is a fatty acid metabolite of chlorophyll that acts as a ligand of retinoid X receptors (RXRs) and peroxisome proliferator-activated receptors (PPARs) and is known to regulate glucose metabolism. Phytanic acid also plays a role in disorders of peroxisomal metabolism such as Refsum disease. This compound induces apoptosis by uncoupling oxidative phosphorylation, stimulating ROS generation, and activating the free fatty acid receptor GPR40 to alter intracellular Ca2+ levels.	price>
R-R-0282	NOTA-FAPI-46	NOTA-FAPI-46 is an analogue of FAPI-46. NOTA-FAPI-46 is useful in the diagnosis or treatment of a disease characterized by overexpression of fibroblast activation protein (FAP). NOTA-FAPI-46 can be used as a PET tracer for detection of diseases or disorders related to fibroblast activation protein.	price>
R-R-0283	FAPI-46	FAPI-46/CAS .2374782-04-2 is a quinoline-based fibroblast activation protein (FAP)-targeted radiotracer. FAPI-46 has higher tumor uptake and prolonged tumor accumulation. FAPI-46 can be used for tumor imaging of a multitude of different cancers.	price>
R-R-0284	FAPI-4	FAPI-4/CAS.2374782-02-0 is a quinoline-based theranostic ligands for the targeting of Fibroblast Activation Protein. FAPI-4 was identified as the most promising tracer for clinical application. Compared with the previously published ligand, FAPI-4 showed excellent stability in human serum, higher affinity for FAP as opposed to CD26, and slower excretion in vitro. FAPI-4 represents a promising tracer for both diagnostic imaging and, possibly, targeted therapy of malignant tumors with a high content of activated fibroblasts, such as breast cancer.	price>

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