Product custom-nanocomposites-lipid-nanoparticle-composite-materials

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Catalog	name	Description	price
R-R-5668	Liposomes for Loading Hydrophobic Drugs	Liposomes for Loading Hydrophobic Drugs (5.0mL). This pre-formed liposome product is created for post loading of hydrophobic small molecule compounds into liposomes. The process of drug incorporation is very straight-forward. Then simply add an aliquot of drug solution (prepared in a water-miscible solvent such as ethanol, DMSO and etc.) into the liposome suspension. The drug molecules can be incorporated into the lipid bilayers by the nature of hydrophobic interactions. The drug solubility therefore could be significantly enhanced. Liposomal drug concentration of 1-2 mg/mL could be achieved for most lipophilic drugs. PEGylation of the liposomes provides not only better formulation stability but also the potential of achieving prolonged in vivo blood circulation. The finished drug loaded formulations are suitable for either in vitro testing or in vivo studies.	price>
R-R-5669	HSPC/CHOL (55:45 mol/mol) Liposomes with Ammonium Sulfate Gradient (100nm)	HSPC/CHOL (55:45 mol/mol) Liposomes with Ammonium Sulfate Gradient (100nm). HSPC/CHO liposomes with ammonium gradient is the formulator choice for loading of weakly basic compounds, because it offers significantly improved drug retention and the ease of use in terms of process parameters such as loading temperature (60-70 deg C). One can use this liposomes as the placebo control for the drug loaded formulation or use the much cheaper plain HSPC/CHOL liposomes as placebo control.	price>
R-R-5670	DSPC/CHOL (55:45 mol/mol) Liposomes with Ammonium Sulfate Gradient (100nm)	DSPC/CHOL (55:45 mol/mol) Liposomes with Ammonium Sulfate Gradient (100nm). DSPC/CHO liposomes with ammonium gradient is the formulator choice for loading of weakly basic compounds, because it offers significantly improved drug retention and the ease of use in terms of process parameters such as loading temperature (60-70 deg C). One can use this liposomes as the placebo control for the drug loaded formulation or use the much cheaper plain DSPC liposomes as placebo control (F10203).	price>
R-R-5671	HSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Liposomes with Ammonium Sulfate Gradient (100nm)	HSPC/CHOL/mPEG-DSPE liposomes with ammonium gradient is the formulator choice in pharmaceutical/biotech industry for both formulation feasibility studies and liposomal product development, because HSPC is essentially equivalent to DSPC (HSPC contains about 85 % DSPC 15% DPPC). The main advantages for using HSPC are its lower cost and availability of GMP quality raw materials.	price>
R-R-5672	DSPC/CHOL/mPEG-DSPE (50:45:5 mol/mol) Liposomes with Ammonium Sulfate Gradient (100nm)	This product is prepared to the finest quality and shipped to you ready for drug loading. DSPC/CHOL/mPEG-DSPE liposomes with ammonium gradient is the formulator choice for loading of weakly basic compounds, because it offers significantly improved drug retention and the ease of use in terms of process parameters such as loading temperature (60-70 deg C)	price>
R-R-5726	Non-PEGylated Magnetic Liposomes	Non-PEGylated magnetic liposomes are nanoparticles formed from lipid bilayers that encapsulate drugs and incorporate magnetic materials, typically iron oxides (like magnetite or maghemite). Without polyethylene glycol (PEG) modifications, these liposomes exhibit enhanced interaction with biological systems, potentially leading to faster clearance from circulation. Their size usually ranges from 100 to several hundred nanometers, making them suitable for targeted drug delivery and biomedical applications. The magnetic properties enable controlled drug release and precise targeting via external magnetic fields, making them particularly valuable in cancer therapy, gene delivery, and imaging modalities like MRI.	price>
R-R-5727	PEGylated Magnetic Liposomes	PEGylated magnetic liposomes are sophisticated nanocarriers composed of lipid bilayers that encapsulate therapeutic agents while incorporating magnetic nanoparticles, such as iron oxide, for enhanced targeting capabilities. The addition of polyethylene glycol (PEG) on the liposomal surface improves biocompatibility, increases circulation time in the bloodstream, and reduces immunogenicity. These liposomes typically range from 100 to 200 nanometers in diameter, enabling efficient drug delivery to specific tissues, particularly in cancer therapy. The magnetic properties allow for targeted delivery and controlled release of encapsulated drugs when subjected to an external magnetic field, enhancing therapeutic efficacy while minimizing side effects. Additionally, the use of PEG helps stabilize the liposomes in biological environments, addressing issues of drug leakage and aggregation. Overall, PEGylated magnetic liposomes represent a promising approach in nanomedicine, combining the advantages of targeted therapy with improved pharmacokinetics for various biomedical applications.	price>
R-R-5728	Non-PEGylated DOTA Liposomes for Remote Loading Radioactive Divalent Cations	DOTA encapsulated liposomes are used for remote loading of radioactive divalent ions such as radioactive copper into the liposomes. Cationic ions will not pass through the membrane if there is no pH gradient. Divalent ion will cross the liposome membrane only when there is a flux of proton across of the lipid membrane. Due to the difference in the pH inside and outside of the liposomes, there will be a constant flux of proton from inside of the liposomes to outside of the liposomes. Due to this flux, divalent cations move in the opposite direction from outside to inside of liposomes. Liposomes are thermodynamically stable structures and not very permeable to divalent cations after they are formed. If there is no pH gradient, the divalent cations cannot move from outside to inside of the liposomes, where they will remain outside and won’t cross the membrane. The driving force for remote loading in proton gradient. The radioactive divalent copper is externally added to the liposomes. The divalent ion passes the membrane using pH gradient method and chelates DOTA.	price>
R-R-5729	PEGylated DOTA Liposomes for Remote Loading Radioactive Divalent	CDOTA encapsulated liposomes are used for remote loading of radioactive divalent ions such as radioactive copper into the liposomes. Cationic ions will not pass through the membrane if there is no pH gradient. Divalent ion will cross the liposome membrane only when there is a flux of proton across of the lipid membrane. Due to the difference in the pH inside and outside of the liposomes, there will be a constant flux of proton from inside of the liposomes to outside of the liposomes. Due to this flux, divalent cations move in the opposite direction from outside to inside of liposomes. Liposomes are thermodynamically stable structures and not very permeable to divalent cations after they are formed. If there is no pH gradient, divalent cations cannot move from outside to inside of the liposomes, where they will remain outside and won’t cross the membrane. The driving force for remote loading in proton gradient. The radioactive divalent copper is externally added to the liposomes. The divalent ion passes the membrane using pH gradient method and chelates DOTA.	price>
R-R-5731	(PEGylated)Doxosome-Doxorubicin Liposomes	The formulation of this doxorubicin liposome is PEGylated and is only used for research purposes and laboratory animal injection. The doxorubicin drug has been remotely loaded into liposomes via ammonium sulfate gradient. Surface reactive doxorubicin liposomes suitable for coupling various antibodies, proteins, peptides, and ligands are also available.	price>

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