Product apis-jak-stat

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Catalog	name	Description	price
R-R-2308	JAK2/FLT3-IN-1 TFA CAS No.2928093-29-0	JAK2/FLT3-IN-1 (TFA)/CAS No.2928093-29-0 is a potent and orally active dual JAK2/FLT3 inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. JAK2/FLT3-IN-1 (TFA) has anti-cancer activity.	price>
R-R-2309	PF-06263276 CAS No.1421502-62-6	PF-06263276 (PF 6263276)/CAS No.1421502-62-6 is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively.	price>
R-R-2310	WHI-P97 CAS No.211555-05-4	WHI-P97/CAS No.211555-05-4 is a potent and selective JAK-3 inhibitor. WHI-P97 is effective in preventing the development allergic asthma in vivo.	price>
R-R-2311	SC99 CAS No.882290-02-0	SC99/CAS No.882290-02-0 is an orally active, selective STAT3 inhibitor targeting JAK2-STAT3 pathway. SC99 docks into the ATP-binding pocket of JAK2. SC99 inhibits phosphorylation of JAK2 and STAT3 with no effects on the other kinases associated with STAT3 signaling. SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activities.	price>
R-R-2312	RGB-286638 free base CAS No.784210-88-4	RGB-286638/CAS No.784210-88-4 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.	price>
R-R-2313	Ilginatinib hydrochloride CAS No.1239358-85-0	Ilginatinib hydrochloride (NS-018 hydrochloride)/CAS No.1239358-85-0 is a highly active and orally bioavailable JAK2 inhibitor, with an IC50 of 0.72 nM, 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM).	price>
R-R-2314	Tyk2-IN-7 CAS No.1609391-90-3	Tyk2-IN-7/CAS No.1609391-90-3 is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 provides robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model.	price>
R-R-2315	Itacitinib adipate CAS No.1334302-63-4	Itacitinib adipate/CAS No.1334302-63-4 is an orally bioavailable and selective JAK1 inhibitor which has been tested for efficacy and safety in a phase II trial in myelofibrosis.	price>
R-C-616	Icotinib cas:610798-31-7	Icotinib(BPI-2009H)is a potent and specific EGFR inhibitor with IC50 of 5 nM, including the EGFR,EGFR(L858R),EGFR(L861Q),EGFR(T790M) and EGFR(T790M,L858R).	price>
R-R-2316	JAK2/FLT3-IN-1 CAS No.2387765-27-5	JAK2/FLT3-IN-1/CAS No.2387765-27-5 is a potent and orally active dual JAK2/FLT3 inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. JAK2/FLT3-IN-1 has anti-cancer activity.	price>

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