Product apis-gpcr-g-protein

Home > products > apis> gpcr-g-protein

Catalog	name	Description	price
R-C-577	VU 0364439 cas:1246086-78-1	VU 0364439 is a positive allosteric modulator(PAM)of mGlu4 receptors(EC50=19.8 nM in vitro for human mGlu4).	price>
R-C-579	Anamorelin cas:249921-19-5	Anamorelin is currently under development for the management of non-small lung cancer associated cachexia/anorexia.	price>
R-C-585	Linagliptin(BI-1356) cas:668270-12-0	Linagliptin (BI-1356) is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM and exhibits a 10,000-fold higher selectivity for DPP-4 than for other dipeptidyl peptidases such as DPP-2, DPP-8,and DPP-9.Linagliptin activates glomerular autophagy in a model of type 2 diabetes.DPP4 mediates ferroptosis in TP53-deficient CRC cells.	price>
R-C-620	Vicriviroc Malate cas:541503-81-5	Vicriviroc maleate(SCH-417690 maleate;SCH-D maleate) is a potent,selective,oral bioavailable and CNS penetrated antagonist of CCR5,with a Ki of 2.5 nM,and also inhibits HIV-1 in PBMC cells,with IC90s of 3.3 nM (JrFL),2.8 nM (ADA-M), 1.8 nM (301657),4.9 nM (JV1083) and 10 nM (RU 570).	price>
R-C-621	Maraviroc(Selzentry, UK-427857) cas:376348-65-1	Maraviroc (UK-427857) is a CCR5 antagonist for MIP-1α,MIP-1βand RANTES with IC50 of 3.3 nM,7.2 nM and 5.2 nM in cell-free assays,respectively.Maraviroc is used in the treatment of HIV infection.	price>
R-C-631	MK4305 cas1030377-33-3	Suvorexant(MK-4305)is a potent,selective,and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia.	price>
R-C-632	Aprepitant (MK-0869) cas:170729-80-3	Aprepitant is classified as an NK1 antagonist.Aprepitant has been shown to inhibit both the acute and delayed emesis induced by cytotoxic chemotherapeutic drugs by blocking substance P landing on receptors in the brains neurons.It has also been shown to increase the activity of the 5-HT3 receptor antagonists ondansetron and the corticosteroid dexamethasone,which are also used to prevent nausea and vomiting caused by chemotherapy.	price>
R-C-645	CP945598（Otenabant ） cas:686344-29-6	Otenabant is a potent and selective cannabinoid receptor CB1 antagonist with Ki of 0.7 nM,exhibits 10,000-fold greater selectivity against human CB2 receptor.	price>
R-C-720	CID-2011756 CAS:638156-11-3	CID 2011756 is an ATP competitive PKD inhibitor,with an IC50 of 3.2 µM for PKD1 in cell free assay,and also shows cellular pan-PKD inhibitory activity against PKD2 and PKD3 (IC50,0.6 and 0.7 µM,respectively).CID 2011756 also has antitumor activity.	price>
R-C-725	tcs1102 CAS No. : 916141-36-1	TCS 1102 is a potent,dual orexin receptor antagonist(Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively).	price>

...

163