Product apis-apoptosis

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Catalog	name	Description	price
R-R-1916	Lometrexol disodium CAS No.120408-07-3	Lometrexol (DDATHF) disodium/CAS No.120408-07-3, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol disodium can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol disodium has anticancer activity. Lometrexol disodium also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor.	price>
R-R-1917	Furanodienone CAS No.24268-41-5	Furanodienone/CAS No.24268-41-5 is one of the major bioactive constituents derived from Rhizoma Curcumae. Furanodienone induced apoptosis.	price>
R-R-1918	GLUT4-IN-2 CAS No.2454113-83-6	GLUT4-IN-2/CAS No.2454113-83-6 is a potent and selective GLUT4 inhibitor with IC50s of 11.4 µM and 6.8 µM for GLUT1 and GLUT4, respectively. GLUT4-IN-2 induces cell apoptosis and cell cycle arrest at G0/G1phase. GLUT4-IN-2 shows potent antitumor activity.	price>
R-R-1919	Phthalazinone pyrazole CAS No.880487-62-7	Phthalazinone pyrazole/CAS No.880487-62-7 is a potent, selective, and orally active inhibitor of Aurora-A kinase with an IC50 of 0.031 μM. Phthalazinone pyrazole can arrests mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells. Phthalazinone pyrazole suppresses the epithelial-mesenchymal transition (EMT) during the differentiation of hepatocyte-like cells (HLCs) from human embryonic stem cells.	price>
R-R-1920	Lometrexol CAS No.106400-81-1	Lometrexol (DDATHF)/CAS No.106400-81-1, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol has anticancer activity. Lometrexol also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor.	price>
R-R-1921	Lometrexol hydrate CAS No.1435784-14-7	Lometrexol (DDATHF) hydrate/CAS No.1435784-14-7, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol hydrate can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol hydrate has anticancer activity. Lometrexol hydrate also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor.	price>
R-R-1922	Pinoresinol CAS No.487-36-5	Pinoresinol/CAS No.487-36-5 is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis.	price>
R-R-1923	EGFR T790M/L858R-IN-2	EGFRT790M/L858R-IN-2 is a potent and selective EGFRT790M/L858R inhibitor with IC50 values of 3.5, 1290 nM for EGFRT790M/L858R, EGFR WT, respectively. EGFRT790M/L858R-IN-2 decreases the expression of p-EGFR, P-AKT, P-ERK1/2. EGFRT790M/L858R-IN-2 induces Apoptosis and cell cycle arrest in the G1 phase. EGFRT790M/L858R-IN-2 shows anti-cancer activity.	price>
R-R-1924	Peimisine CAS No.19773-24-1	Peimisine (Ebeiensine)/CAS No.19773-24-1 is a muscarinic M receptor antagonist and angiotensin converting enzyme (ACE) inhibitor. Peimisine shows anti-tumor, anti-inflammatory, antihypertensive activities. Peimisine can induce apoptosis and be used in cough and asthma research.	price>
R-R-1925	Dalotuzumab CAS No.1005389-60-5	Dalotuzumab (MK-0646)/CAS No.1005389-60-5 is a recombinant humanized monoclonal antibody (IgG1 type) targeting IGF-1R. Dalotuzumab acts by inhibiting IGF-1- and IGF-2-mediated tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation. Dalotuzumab also induces apoptosis and cycle arrest. Dalotuzumab in combination with other anticancer agents such as statins can enhance the antitumor activity of Dalotuzumab in vitro and in vivo.	price>

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