Product apis-apoptosis

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Catalog	name	Description	price
R-R-1660	Patulin CAS No.149-29-1	Patulin (Terinin)/CAS No.149-29-1 is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, is suspected to be clastogenic, mutagenic, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage.	price>
R-R-1662	Oxychlororaphine CAS No.550-89-0	Oxychloroaphine/CAS No.550-89-0 could be isolated from the bacterium Pantoea agglomerans naturally present in soil. Oxychloroaphine has broad-spectrum antifungal activity. Oxychloroaphine has cytotoxicity in a dose-dependent manner and induces apoptosis. Oxychloroaphine can be used in research of cancer.	price>
R-R-1663	EPZ020411 hydrochloride CAS No.2070015-25-5	EPZ020411 hydrochloride/CAS No.2070015-25-5 is a selective inhibitor of PRMT6 with an IC50 of 10 nM, it has >10 folds selectivity for PRMT6 over PRMT1 and PRMT8. EPZ020411 hydrochloride can be used for the research of cancer.	price>
R-R-1664	VTP50469 fumarate CAS No.2169919-29-1	VTP50469 fumarate/CAS No.2169919-29-1 is a potent, highly selective and orally active Menin-MLL interaction inhibitor with a Ki of 104 pM. VTP50469 fumarate has potently anti-leukemia activity.	price>
R-R-1665	Seribantumab CAS No.1334296-12-6	Seribantumab (MM 121)/CAS No.1334296-12-6 is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models.	price>
R-R-1666	VTP50469 CAS No.2169916-18-9	VTP50469/CAS No.2169916-18-9 is a potent, highly selective and orally active Menin-MLL interaction inhibitor with a Ki of 104 pM. VTP50469 has potently anti-leukemia activity.	price>
R-R-1667	EPZ020411 CAS No.1700663-41-7	EPZ020411/CAS No.1700663-41-7 is a selective inhibitor of PRMT6 with an IC50 of 10 nM, has >10 folds selectivity for PRMT6 over PRMT1 and PRMT8. EPZ020411 can be used for the research of cancer.	price>
R-R-1668	Nampt-IN-3 CAS No.2121591-52-2	Nampt-IN-3 (Compound 35)/CAS No.2121591-52-2 simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death.	price>
R-R-1669	Physalin F CAS No.57423-71-9	Physalin F/CAS No.57423-71-9 is a secosteroid with potent anti-inflammatory and immunomodulatory activities. Physalin F induces apoptosis of PBMC, decreasing the spontaneous proliferation and cytokine production caused by Human T-lymphotropic virus type 1 (HTLV-1) infection.	price>
R-R-1671	Ixabepilone CAS No.219989-84-1	Ixabepilone (BMS-247550)/CAS No.219989-84-1 is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis.	price>

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