Product peptide-Inhibitory-peptide

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Catalog	name	Description	price
R-M-1237	TRAP-14 amide trifluoroacetate salt,CAS :141923-36-6	TRAP-14 amide, SFLLRNPNDKYEPF-NH2, has been shown to inhibit monocyte spreading on fibronectin-coated slides. The rapidly induced withdrawal of pseudopodial processes and rounding of the cells is accompanied by nitric oxide and endothelin-1 release. Spreading might be inhibited by autocrine endothelin-1 release and subsequent endothelin B receptor-dependent nitric oxide production.	price>
R-M-1239	TRAF6 Peptide trifluoroacetate salt,CAS:852805-92-6	The cell-permeable peptide inhibits the interaction of TRAF6, an E3 ubiquitin ligase, with p62 (sequestosome 1). P62 has been shown to be a polyubiquitin shuttling factor which binds to K63-polyubiquitinated proteins. TRAF6-p62 interaction modulators may be used to treat neuropathologies such as Alzheimer disease or Huntington disease.	price>
R-M-1254	Z-Ala-Glu-Val-DL-Asp-fluoromethylketone,CAS:419543-05-8	Selective inhibitor of caspase-10. Z-AEVD-FMK effectively blocked caspase-3 activation and significantly attenuated As₂O₃-triggered apoptosis.	price>
R-M-1257	Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde,CAS :158442-41-2	Z-IE(OtBu)AL-CHO is an inhibitor of chymotrypsin-like activity of the multicatalytic proteinase complex (MPC; 20S proteasome) in HT4 cells. It is the first inhibitor reported so far which can cause accumulation of ubiquitinylated proteins in neuronal cells. Furthermore, this compound induced massive apoptosis in murine leukaemia L1210 cells. Therefore, proteasome inhibitors may be considered as potential anti-neoplastic agents.	price>
R-M-1259	Z-Ile-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone,CAS: 1926163-59-8	Cell permeable inhibitor of caspase-8 and granzyme B.The bis-methyl ester of Z-IETD-FMK blocked CD95-induced apoptosis.	price>
R-M-1262	Z-Phe-Lys-2,4,6-trimethylbenzoyloxy-methylketone trifluoroacetate salt	Z-FK-ck is a very effective in vivo cathepsin B inhibitor in rats. It inhibited rat liver cathepsin B activity ex vivo with ED₅₀ = 5 mg/kg intraperitoneally and 18 mg/kg orally at 4-5 h postdose, and 2.4 mg/kg subcutaneously at 24 h postdose. It also inhibited rat cathepsin B activity in heart and skeletal muscle with ED₅₀ = 0.1 and 1.0 mg/kg subcutaneously at 20 h postdose. Z-FK-ck is an inhibitor of gingipain K.	price>
R-M-1263	Z-Phe-Phe-diazomethylketone,CAS :65178-14-5	Z-FF-DMK, a cathepsin L-selective inhibitor.	price>
R-M-1278	Calcineurin Autoinhibitory Peptide,Cas:148067-21-4	Calcineurin Autoinhibitory Peptide is a selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 μM). Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM).	price>
R-M-1279	CaMKII [290-309] Inhibitory Peptide,Cas:115044-69-4	This peptide is a potent calmodulin antagonist and an inhibitor for calcium/calmodulin-dependent protein kinase II (CaMKII), which belongs to the CAMK Ser/Thr protein kinase family. The sequence derives from the residues 290-309 within the calmodulin-binding domain of human CaMKII alpha. CaMKII is a prominent kinase in the central nervous system that functions in long-term potentiation and neurotransmitter release. This peptide inhibits CaMKII activation by blocking calmodulin binding to CaMKII.	price>
R-M-1280	Bradykinin Potentiator C Peptide,CAS:30953-20-9	Bradykinin potentiator C, secreted by the viper venom gland, inhibits the activity of the angiotensin-converting enzyme (ACE) and enhances the action of bradykinin by inhibiting the peptidases that inactivate it.	price>

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