Catalog name Description price
R-C-1846 BI-882370 CAS:1392429-79-6 BI-882370 is a potent and selective RAF kinase inhibitor that binds to the ATP binding site of the kinase positioned in the DFG-out(inactive)conformation of the BRAF kinase.BI-882370(BI 882370)inhibits the oncogenic BRAFV600E-mutant,the WT BRAF and CRAF kinases with IC50s of 0.4,0.8,and 0.6nM,respectively.BI-882370 also inhibits SRC family kinases. price>
R-C-1862 NG25 CAS:1315355-93-1 NG-25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1.It also inhibits the Src family kinases Src and LYN and Abl family kinases as well as CSK,FER,and p38.NG 25 prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells.It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097,respectively.NG 25 decreases cell viability of HCT116KRASWT,and to a greater degree of HCT116KRASG13D, colorectal cancer cells in a concentration-dependent manner.It also reduces tumor growth and increases the number of TUNEL-positive tumor cells in a CT26KRASG12D mouse orthotopic model of colorectal cancer. price>
R-C-1865 Takinib CAS:1111556-37-6 Takinib(EDHS-206)is a potent and selective TAK1 inhibitor with an IC50 of 9.5 nM,more than 1.5 log more potent than the second and third ranked targets,IRAK4(120 nM)and IRAK1(390 nM),respectively.Takinib induces apoptosis. price>
R-C-1898 AS703026 CAS:1236699-92-5 AS703026 is a novel,selective,orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation. price>
R-C-1906 KO-947 CAS:1695533-89-1 KO-947 is a potent and selective inhibitor of ERK1/2 kinases.KO-947 blocks ERK signaling and proliferation of tumor cells exhibiting dysregulation of MAPK pathway signaling at low nanomolar concentrations. price>
R-C-1911 Tomivosertib (eFT-508) CAS:1849590-01-7 Tomivosertib(eFT-508)is a potent and selective MNK1/2 inhibitor with IC50s of 2.4nM and 1 nM,respectively.It potentially results in decreased tumor cell proliferation and tumor growth.Tomivosertib(eFT-508)inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance. price>
R-C-1921 ASK1-IN-1 CAS:2411382-24-4 ASK1-IN-1 is a CNS-penetrant ASK1(apoptosis signal-regulating kinase 1) inhibitor,with good potency(cell IC50=138nM;Biochemical IC50=21nM). price>
R-C-3018 Dabrafenib CAS:1195765-45-7 Dabrafenib, also known as GSK2118436 , is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene.Only for scientific research, not for human body. price>
R-C-1990 GDC0623 CAS:1168091-68-6 GDC-0623(G-868)is an orally active,selective MEK inhibitor with potential antineoplastic activity.MEK inhibitor GDC-0623 specifically inhibits mitogen-activated protein kinase kinase(MEK or MAP/ERK kinase),resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation.MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth;constitutive activation of this pathway has been implicated in many cancers.Check for active clinical trials or closed clinical trials using this agent. price>
R-C-2049 JWG-071 CAS:2250323-50-1 JWG-071 is the first reported kinase-selective chemical probe for ERK5.JWG-071 improves ERK5 activity and BRD4 selectivity.JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology. price>