||Necrosulfonamide is a novel inhibitor of MLKL(mixed lineage kinase domain-like). Necrosulfonamide is a cell-permeable inhibitor that covalently modifies Cys88 and blocks human MLKL adaptor function.
||Piperlongumine is a alkaloid,possesses ant-inflammatory,antibacterial, antiangiogenic,antioxidant,antitumor,and antidiabetic activities.Piperlongumine induces ROS,and induces apoptosis in cancer cell lines.Piperlongumine shows anti-cardiac fibrosis activity,suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway.
||Lucitanib , also known as E-3810 and AL3810, is a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. VEGFR/FGFR dual kinase inhibitor E-3810 inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death.
||Anisomycin(Flagecidin,Wuningmeisu C)is a bacterial antibiotic isolated from Streptomyces griseolus, which inhibits protein synthesis, and also act as a JNK activator. Anisomycin upregulates autophagy and increases apoptosis.