Catalog name Description price
R-C-1496 BI-78D3 CAS:883065-90-5 BI-78D3(JNK Inhibitor X),is a potent JNK inhibitor.BI-78D3 dose-dependently inhibits the phosphorylation of JNK substrates both in vitro and in cell.BI-78D3 not only blocks JNK dependent Con A-induced liver damage but also restores insulin sensitivity in mouse models of type 2 diabetes. price>
R-C-1505 xmd8-92 CAS:1234480-50-2 XMD8-92 is a potent ERK5(BMK1)/BRD4 inhibitor with Kds of 80 and 190 nM, respectively.XMD8-92 inhibits DCAMKL2,PLK4 and TNK1 with Kds of 190,600 and 890 nM,respectively.Anti-cancer activity. price>
R-C-1531 Binimetinib (MEK-162, ARRY-162, ARRY-438162) Binimetinib(MEK162)is an oral and selective MEK1/2 inhibitor.Binimetinib (MEK162)inhibits MEK with an IC50 of 12 nM. price>
R-C-1558 SL327 CAS:305350-87-2 SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18μM/0.2μM,no activity towards Erk1,MKK3,MKK4,c-JUN,PKC,PKA,or CamKII;capable of transport through the blood-brain barrier. price>
R-C-1567 Pamapimod CAS:449811-01-2 Pamapimod(Ro4402257)is a potent,selective and orally active p38 MAPK inhibitor with IC50s of 14 nM and 480 nM and Kis of 1.3 nM and 120 nM for p38α and p38β,respectively.Pamapimod has no activity against p38δ or p38γ isoforms.Pamapimod has the potential for rheumatoid arthritis and other autoimmune diseases treatment. price>
R-C-1598 BMS582949(HCl) CAS:912806-16-7 (HCl) BMS-582949(PS540446)is a potent and selective p38 mitogen-activated protein kinase(p38 MAPK)inhibitor with IC50 of 13nM,inhibiting both p38 kinase activity and activation of p38. price>
R-C-1613 Pluripotin (SC1) CAS:839707-37-8 Pluripotin(SC1)is a dual inhibitor of extracellular signal-regulated kinase 1(ERK1,MAPK3)and RasGAP.Maintains embryonic stem cell(ESC)self-renewal.Pluripotin also inhibits RSK1,RSK2,RSK3 and RSK4 with IC50 of 0.5 µM,2.5 µM,3.3µM and 10.0µM,respectively. price>
R-C-1705 GNE-3511 CAS:1496581-76-0 GNE-3511 is a potent and selective dual leucine zipper kinase(DLK,MAP3K12) inhibitors with activity in neurodegeneration models.GNE-3511 displays concentration-dependent protection of neurons from degeneration in vitro and demonstrated dose-dependent activity in two different animal models of disease. GNE-3511 displays protection of primary neurons in an in vitro axon degeneration assay as well as activity in the mouse models of glaucoma/optic neuropathy (optic nerve crush)and Parkinson is disease(MPTP)after oral dosing. price>
R-C-1709 RAF-709 CAS:1628838-42-5 RAF709 is a potent inhibitor of B/C RAF kinase with almost equivalent IC50 values of 0.4nM for B-RAF and C-RAF,showing a high level of selectivity, demonstrating greater than 99% on-target binding to BRAF,BRAFV600E,and CRAF at 1 μM and very few off-targets with DDR1(>99%),DDR2(86%),FRK(92%),and PDGFRb (96%),the only kinases with binding>80% at 1μM. price>
R-C-1726 Vemurafenib (PLX4032) CAS:918504-65-1 Vemurafenib(PLX4032,RG7204,RO5185426)is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay.10-fold selective for B-RafV600E over wild-type B-Raf in enzymatic assays and the cellular selectivity can exceed 100-fold.Vemurafenib(PLX4032,RG7204)induces autophagy. price>