Catalog name Description price
R-C-1739 AS 602801 CAS:848344-36-5 Bentamapimod(AS 602801)is an ATP-competitive JNK inhibitor with IC50 of 80 nM,90 nM,and 230 nM for JNK1,JNK2,and JNK3,respectively. price>
R-C-1767 Pexmetinib(ARRY-614) CAS:945614-12-0 Pexmetinib is a potent inhibitor of cytokine synthesis,via the dual inhibition of p38 mitogen-activated protein kinase(MAPK),and Tie2/Tek receptor tyrosine kinase. price>
R-C-1784 Acumapimod (BCT-197) CAS:836683-15-9 Acumapimod(BCT197)is an orally active p38 MAP kinase inhibitor,with an IC50 of less than 1 μM for p38α. price>
R-C-1794 PLX8394 CAS:1393466-87-9 PLX8394 is a next-generation,orally available,small-molecule BRAF inhibitor with IC50 values of 3.8 nM,14 nM and 23 nM for BRAF(V600E),WT BRAF and CRAF respectively.It has potential antineoplastic activity. price>
R-C-1798 OTS514 CAS:1338540-63-8 OTS514,a thieno[2,3-c]quinolone compound,is a highly potent TOPK inhibitor with an IC50 value of 2.6 nM.The compound can inhibit TOPK kinase activity. price>
R-C-1799 OTS964 CAS:1338545-07-5 OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM.OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. OTS964 treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts. price>
R-C-1805 Lifirafenib (BGB-283) CAS:1446090-79-4 Lifirafenib(BGB-283,Beigene-283)potently inhibits RAF family kinases and EGFR activities in biochemical assays with IC50 values of 23,29 and 495 nM for the recombinant BRAFV600E kinase domain,EGFR and EGFR T790M/L858R mutant. price>
R-C-1809 B-Raf inhibitor 1 CAS:1093100-40-3 Raf inhibitor 1 is a potent Raf kinase inhibitor with Kis of 1 nM,1nM,and 0.3 nM for B-RafWT,B-RafV600E,and C-Raf,respectively. price>
R-C-1810 Agerafenib (RXDX-105) CAS:1188910-76-0 CEP-32496 is an orally available v-raf murine sarcoma viral oncogene homolog B1 (B-raf)serine/threonine protein kinase inhibitor with potential antineoplastic activity. price>
R-C-1815 FR180204 CAS:865362-74-9 FR 180204 is an ATP-competitive,selective ERK inhibitor with Ki of 0.31μM and 0.14μM for ERK1 And ERK2,respectively.It is 30-fold less potent against the related kinase p38α and failed to inhibit any kinases(MEK1,MKK4,IKKα,PKCα, Src,Syc,and PDGFα)at less than 30μM. price>