Catalog name Description price
R-C-2084 Belvarafenib (HM95573) CAS:1446113-23-0 Belvarafenib(GDC5573,HM95573,RG6185)is a selective and orally bioavailable pan-RAF kinase inhibitor with IC50 values of 41 nM,7nM and 2nM for BRAF WT, BRAF(V600E)and CRAF kinases,respectively. price>
R-C-2110 LUT-014 CAS:2274819-46-2 LUT014 is a B-Raf inhibitor with an IC50 of 11.7nM,and developed to reduce dose-limiting acneiform lesions associated EGFR Inhibitors treatment.Extracted from patent WO 2019026065A2. price>
R-C-2124 JNK-IN-8 CAS:1410880-22-6 JNK-IN-8(JNK Inhibitor XVI)is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 4.7nM,18.7nM and 1nM,>10-fold selectivity against MNK2,Fms and no inhibition to c-Kit,Met,PDGFRβin A375 cell line. price>
R-C-2154 Hypaphorine CAS:487-58-1 Hypaphorine is an indole-3-acetic acid antagonist which specifically compete with indole-3-acetic acid in binding to the indole-3-acetic acid-binding site in plant peroxidases.Hypaphorine and endogenous indole-3-acetic acid counteract in controlling root hair elongation. price>
R-C-2177 Sorafenib (BAY 43-9006) CAS:284461-73-0 Sorafenib(BAY 43-9006,NSC-724772)is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays,respectively.Sorafenib inhibits VEGFR-2,VEGFR-3,PDGFR-β,Flt-3 and c-KIT with IC50 of 90 nM,20nM,57nM,59nM and 68nM,respectively.Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity. price>
R-C-2213 Donafenib (Sorafenib D3) CAS:1130115-44-4 Sorafenib(D3)(Bay 43-9006 (D3))is the deuterium labeled Sorafenib.Sorafenib is a multikinase inhibitor IC50s of 6nM,20nM,and 22nM for Raf-1, B-Raf,and VEGFR-3, respectively. price>
R-C-2484 AZ-628 CAS:878739-06-1 AZ-628 is a selective,orally available Raf inhibitor with excellent pharmacokinetic properties and robust tumor growth inhibition in xenograft studies((IC50 values are 29,34 and 105 nM for c-Raf1,B-RafV600E and wild-type B-Raf,respectively).AZ-628 inhibits growth,and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation. price>
R-C-2485 AZD-8330 CAS:869357-68-6 AZD8330(ARRY704 and ARRY424704)is an orally active,selective MEK inhibitor with potential antineoplastic activity.MEK inhibitor AZD8330 specifically inhibits mitogen-activated protein kinase kinase 1(MEK or MAP/ERK kinase1),resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. price>
R-C-2560 PD318088 CAS:391210-00-7 PD318088 is a potent,allosteric and non-ATP competitive MEK1/2 inhibitor,an analog of PD184352(HY-50295).PD318088 binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. price>
R-C-2561 GDC-0879 (AR-00341677) CAS:905281-76-7 GDC-0879(AR-00341677)is a novel,potent,and selective B-Raf inhibitor with IC50 of 0.13nM in A375 and Colo205 cells with activity against c-Raf as well;no inhibition known to other protein kinases. price>