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Catalog	name	Description	price
R-R-4717	WRN inhibitor 4 CAS No.2923009-45-2	WRN inhibitor 4 (example 107)/CAS No.2923009-45-2, a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor. WRN inhibitor 4 can be used for the research of cancer.	price>
R-C-3048	LY303511 hydrochloride cas:2070014-90-1	LY303511 hydrochloride is a structural analogue of LY294002. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. LY303511 does not inhibit PI3K.	price>
R-R-4718	POL1-IN-1 CAS No.1822358-25-7	POL1-IN-1/CAS No.1822358-25-7 is a RNA polymerase 1 (POL1, also known as Pol I) inhibitor with an IC50 of less than 0.5 uM. POL1-IN-1 inhibits ribosome biogenesis by inhibiting POL1 transcription.	price>
R-C-3049	GNE-477 CAS:1032754-81-6	GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with an IC50 of 4 nM for PI3Kα and Kiapp of 21 nM for mTOR.	price>
R-R-4719	ML372 CAS No.1331745-61-9	ML372/CAS No.1331745-61-9 inhibits survival motor neuron (SMN) protein ubiquitination, increases SMN protein stability without affecting mRNA expression. ML372 improves spinal muscular atrophy (SMA) in mice. ML372 is brain penetrant and has a reasonable exposure and half-life in vivo.	price>
R-C-3050	LY 303511 CAS:154447-38-8	LY303511, an inactive analogue of LY294002, is a mTOR inhibitor that did not inhibit PI3-K.	price>
R-R-4720	RNase L-IN-1	RNase L-IN-1 (compound 17a) is an inhibitor of RNase L, or Ribonuclease L. RNase L degrades RNAs to prevent viral replication, and mediates the innate immune responses and inflammation.	price>
R-C-3051	WYE-125132 (WYE-132) CAS:1144068-46-1	WYE-125132 is an ATP-competitive and specific inhibitor of mTORC1 and mTORC2 (IC50 = 0.19 nM; >5,000-fold selective versus PI3Ks).	price>
R-R-4721	Cytarabine triphosphate trisodium CAS No.1179343-17-9	Cytarabine triphosphate (Ara-CTP) trisodiu/CAS No.1179343-17-9, an active metabolite of Cytarabine, is a competitive inhibitor of DNA synthesis. Intracellular Cytarabine triphosphate trisodiu levels can be used to predict chemosensitivity of leukemic blasts to Cytarabine.	price>
R-C-3052	INK 128 (MLN0128) CAS:1224844-38-5	INK 128 is a TORC1/2 inhibitor, is also an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity.	price>
R-R-4722	1,1,1-Trifluoroethyl-PEG4-azide CAS: 1817735-35-5	1,1,1-Trifluoroethyl-PEG4-azide/CAS: 1817735-35-5 is a crosslinker containing an azide group and a trifluoroethyl group. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. The trifluoroethyl group is used to react with lysine and other primary amine groups in proteins, antibody and other molecules and surfaces.	price>
R-C-3053	GDC-0349 CAS:1207360-89-1	GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases.	price>
R-R-4723	1,1,1-Trifluoroethyl-PEG5-Propargyl CAS: 1817735-37-7	1,1,1-Trifluoroethyl-PEG5-Propargyl/CAS: 1817735-37-7 forms triazole linkage with azides via copper catalyzed azide-alkyne Click Chemistry. The trifluoroethyl group is reactive towards primary amine groups in proteins, antibody and other molecules and surfaces.	price>
R-C-3054	WAY-600 CAS:1062159-35-6	WAY-600 is a single digit nanomolar inhibitor of the mTOR kinases, with significant selectivity for these enzymes over phosphatidylinositol 3-kinase (PI3K) isofoms (>100-fold).	price>
R-R-4724	1,1,1-Trifluoroethyl-PEG2-azide CAS: 1835759-68-6	1,1,1-Trifluoroethyl-PEG2-azide/CAS: 1835759-68-6 is a crosslinker containing an azide group and a trifluroethyl group. The azide group can participate in Click Chemistry reactions with reagents such as alkynes, DBCO and BCN. The hydrophilic PEG spacer increases solubility in aqueous media. The trifluoroethyl group is used to react with lysine and other primary amine groups in proteins, antibody and other molecules and surfaces.	price>
R-C-3055	WYE-687 CAS: 1062161-90-3	WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(T308). Selectivity for mTOR is greater than PI3Kα (>100-fold) and PI3Kγ (>500-fold).	price>
R-R-4725	1,1,1-Trifluoroethyl-PEG4-aminooxy CAS: 1895922-78-7	1,1,1-Trifluoroethyl-PEG4-aminooxy/CAS: 1895922-78-7 is a fluorine containing PEG molecule. The aminooxy group can be used in bioconjugation and It reacts with an aldehyde to form an oxime bond.	price>
R-C-3056	WYE-354 CAS:1062169-56-5	WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM, blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) not P-AKT(T308), selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).	price>
R-R-4726	Octakis-(6-bromo-6-deoxy)-y-cyclodextrin CAS No.53784-84-2	Octakis-(6-bromo-6-deoxy)-γ-cyclodextrin/CAS No.53784-84-2 is a perbrominated γ-cyclodextrin at the primary side. Octakis-(6-bromo-6-deoxy)-γ-cyclodextrin is also a commonly used intermediate in the modification of cyclodextrin.	price>
R-C-3057	Ridaforolimus (Deforolimus, MK-8669) CAS:572924-54-0	Ridaforolimus (Deforolimus, MK-8669, AP23573) is a selective mTOR inhibitor with IC50 of 0.2 nM in HT-1080 cell line.	price>

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