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Catalog	name	Description	price
R-C-2783	Thioperamide CAS:106243-16-7	Thioperamide(MR-12842)is a potent,orally available,brain penetrant and selective H3 receptor antagonist with a Ki of 4.3nM for inhibition of [3H]histamine release.Thioperamide inhibits [3H]histamine synthesis with a Ki of 31nM.	price>
R-R-4483	TAK-715 CAS No.303162-79-0	TAK-715/CAS No.303162-79-0 is an orally active and potent p38 MAPK inhibitor with IC50s of 7.1 nM, 200 nM for p38α and p38β, respectively. TAK-715 inhibits casein kinase I (CK1δ/ε) to regulate activation of Wnt/β-catenin signaling. TAK-715 shows good significant efficacy in a rat arthritis model.	price>
R-C-2784	Risperidone CAS:106266-06-2	Risperidone is a serotonin 5-HT2 receptor blocker,P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist,with Kis of 4.8,5.9nM for 5-HT2A and dopamine D2 receptor,respectively.	price>
R-R-4484	CKI-7 free base CAS No.120615-25-0	CKI-7 free base/CAS No.120615-25-0 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 free base is a selective Cdc7 kinase inhibitor. CKI-7 free base also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 free base has a much weaker effect on casein kinase II and other protein kinases.	price>
R-C-2785	A 987306 CAS:1082954-71-9	A-987306 is a potent histamine H4 receptor antagonist that is selective for H3,H1 and H2 receptors.A-987306 blocks zymosan-induced neutrophil reflux and attenuates thermal hypersensitivity in vivo.	price>
R-R-4485	BioE-1115 CAS No.1268863-35-9	BioE-1115/CAS No.1268863-35-9 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC50 of ~4 nM. BioE-1115 is also a potent casein kinase 2α inhibitor with an IC50 of ~10 μM.	price>
R-C-2786	Mizolastine CAS:108612-45-9	Mizolastine is a histamine H1-receptor antagonist with IC50 of 47nM used in the treatment of hay fever(seasonal allergic rhinitis),hives and other allergic reactions.	price>
R-R-4486	AMG-548 dihydrochloride CAS No.2518299-32-4	AMG-548 dihydrochloride/CAS No.2518299-32-4, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 dihydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM). AMG-548 dihydrochloride inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε.	price>
R-C-2787	BP 554 maleate CAS:1221401-95-1	BP-554 maleate is a selective agonist of 5-HT1A receptor.BP-554 maleate is a selective 5-HT1A receptor agonist.BP-554 showed higher affinity for 5-HT1A receptor than for 5-HT1-non-A,5-HT2,α2-adrenergic,dopamine D2 and benzodiazepine receptors.	price>
R-R-4487	CK1-IN-1 CAS No.1784751-20-7	CK1-IN-1/CAS No.1784751-20-7 is a casein kinase 1 (CK1) inhibitor extracted from patent WO2015119579A1, compound 1c, has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MAPK, respectively.	price>
R-C-2788	MFZ 10-7 CAS:1224431-15-5	High affinity negative allosteric modulator at the mGlu5 receptor(Ki=0.67nM).Potently inhibits mGlu5 glutamate-mediated calcium mobilization(IC50=1.22nM).Inhibits cocaine-taking and cocaine-seeking behavior in rats.	price>
R-R-4488	PF-5006739 CAS No.1293395-67-1	PF-5006739/CAS No.1293395-67-1 is a potent and selective inhibitor of CK1δ/ε with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 attenuats opioid agent-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity.	price>
R-C-2789	ATB-346 CAS:1226895-20-0	Otenaproxesul(ATB-346),an orally active non-steroidal anti-inflammatory drug(NSAID),inhibits cyclooxygenase-1 and 2(COX-1 and 2).Otenaproxesul possesses antiinflammatory and antinociceptive activities.	price>
R-R-4489	BTX161 CAS No.2052301-24-1	BTX161/CAS No.2052301-24-1, a Thalidomide analog, is a potent CKIα degrader. BTX161 mediates degradation of CKIα better than Lenalidomide in human AML cells and activates DNA damage response (DDR) and p53, while stabilizing the p53 antagonist MDM2.	price>
R-C-2790	AZD3839 CAS:1227163-84-9	AZD3839 free base is a potent and selective orally active,brain-permeable BACE1 inhibitor(Ki=26nM).AZD3839 free base shows 14 and>1000-fold selectivity against BACE2 and cathepsin D,respectively.AZD3839 free base exhibits dose-and time-dependent lowering of plasma,brain,and cerebrospinal fluid Aβ levels in mouse,guinea pig,and non-human primate.	price>
R-R-4490	CK2/ERK8-IN-1 CAS No.1085822-09-8	CK2/ERK8-IN-1/CAS No.1085822-09-8 is a dual casein kinase 2 (CK2) (Ki of 0.25 µM) and ERK8 (MAPK15, ERK7) inhibitor with IC50s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with Kis of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy.	price>
R-C-2791	Iguratimod CAS:123663-49-0	Iguratimod is an antirheumatic agent,acts as an inhibitor of COX-2,with an IC50 of 20μM(7.7μg/mL),but shows no effect on COX-1.Iguratimod also inhibits macrophage migration inhibitory factor(MIF)with an IC50 of 6.81μM.	price>
R-R-4491	Epiblastin A CAS No.16470-02-3	Epiblastin A/CAS No.16470-02-3 is an ATP competitive casein kinase 1 (CK1) inhibitor with IC50s of 8.9, 0.5, and 4.7 µM for CK1α, CK1δ, and CK1 ɛ, respectively. Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of CK1.	price>
R-C-2792	TCN 238 CAS:125404-04-8	TCN238 is an orally bioavailable mGlu4 receptor positive allosteric modulator (PAM)with an EC50 of 1μM.	price>
R-C-3322	DSPE-PEG550-RGD(ARG-GLY-ASP)	Phospholipid polyethylene glycol RGD can be used for passive targeting,active targeting and drug delivery of micelles and vesicles.DSPE is a saturated 18 carbon phospholipid,which is commonly used in the synthesis of liposomes. Polyethylene glycol (PEG)-coupled DSPE is hydrophilic and can be used for drug delivery,gene transfection and biomolecular modification.PEGylation of phospholipid significantly improved the blood circulation time and stability of capsule drugs.Polyethylene glycol can enhance solubility and stability,reduce the surface nonspecific binding of charged molecules,and reduce the immunogenicity of peptides.	price>

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