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Catalog	name	Description	price
R-R-4656	PCNA-I1 CAS No.444930-42-1	PCNA-I1/CAS No.444930-42-1 is a potent PCNA (proliferating cell nuclear antigen) inhibitor. PCNA-I1 directly binds PCNA trimers with a Kd of 0.41 μM and exhibits antitumor activity both in vitro and in vivo.	price>
R-C-2987	RO-9187 CAS:876708-03-1	Ro-9187 is a highly effective HCV replication inhibitor with an IC50 value of 171 nm. Only for scientific research, not for human body.	price>
R-R-4657	CP681301 CAS No.865317-32-4	CP681301/CAS No.865317-32-4 is a potent CDK5 inhibitor. CP681301 shows antiproliferative activity. CP681301 decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in GSCs (Glioma stem cells). CP681301 reduces self-renewal in mouse glioma xenografts. CP681301 shows anti-tumor activity in Drosophila.	price>
R-C-2988	RO4929097 CAS:847925-91-1	RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.Only for scientific research,not for human body.	price>
R-R-4658	b-Amanitin CAS No.21150-22-1	β-Amanitin/CAS No.21150-22-1 is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs).	price>
R-C-2989	DDAO,CAS:118290-05-4	DDAO is a potential near infrared (NIR) red fluorescent probe with adjustable excitation wavelength (600-650   nm) and long emission wavelength（ λ em = 656 nm).DDAO can be used to detect the activities of different enzymes, such as β- Galactosidase, sulfatase, protein phosphatase 2A, carboxylesterase 2, human albumin and esterase.Only for scientific research, not for human body.	price>
R-R-4659	Lomibuvir CAS No.1026785-55-6	Lomibuvir (VX-222)/CAS No.1026785-55-6, a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis.	price>
R-C-2990	U0126-EtOH CAS:1173097-76-1	U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. This inhibition of MEK1/2 is noncompetitive with ERK and ATP.Only for scientific research, not for human body.	price>
R-R-4660	Clevudine CAS No.163252-36-6	Clevudine (L-FMAU)/CAS No.163252-36-6, a nucleoside analog of the unnatural L-configuration, has potent anti-HBV activity with long half-life, low toxicity. Clevudine is a non-competitive inhibitor that is not incorporated into the viral DNA but rather binds to the polymerase. Clevudine is active against cowpox virus respiratory infection in mice.	price>
R-C-2991	Seletalisib cas:1362850-20-1	Seletalisib (UCB5857) is a potent and selective PI3Kδ inhibitor, with IC50 of 12 nM. Seletalisib inhibits T-cell differentiation to Th1, Th2, and Th17 subtypes.Only for scientific research, not for human body.	price>
R-R-4661	RG7800 tetrahydrochloride	RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; RG7800 hydrochloride has the potential to treat spinal muscular atrophy.	price>
R-C-2992	Glaucocalyxin A cas:79498-31-0	Glaucocalyxin A is an ent-kauranoid diterpene from Rabdosia japonica var. Glaucocalyxin A induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Only for scientific research, not for human body.	price>
R-R-4662	Rifalazil CAS No.129791-92-0	Rifalazil (KRM-1648; ABI-1648)/CAS No.129791-92-0, a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase. Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml. Rifalazil (KRM-1648; ABI-1648) has the potential for the treatment of Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB).	price>
R-C-2993	PQR530 CAS:1927857-61-1	PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation with IC50 values of 0.07 µM.Only for scientific research, not for human body.	price>
R-R-4663	T2AA CAS No.1380782-27-3	T2AA/CAS No.1380782-27-3 is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase.	price>
R-C-2994	GDC-0077 CAS:2060571-02-8	GDC-0077 is a potent and selective PI3K inhibitor. GDC-0077 blocks an enzyme involved in cancer growth called PI3K. GDC0077 binds to and inhibits various members of the PI3K family, including activating mutations in the catalytic alpha isoform PIK3CA. PI3K inhibition prevents the activation of the PI3K-mediated signaling pathway and results in the inhibition of growth and survival of PI3K-overexpressing tumor cells.Only for scientific research, not for human body.	price>
R-R-4664	1,1,1-Trifluoroethyl-PEG4-amine CAS: 1872433-72-1	1, 1, 1-Trifluoroethyl-PEG4-Amine/1,1,1-Trifluoroethyl-Polyethylene glycol 4-amine/CAS: 1872433-72-1 is a PEG linker with a trifluoroethyl and amine moiety. The amine can react with carboxylic acids, activated NHS esters and other carbonyl compounds. The hydrophilic PEG chain increases the water solubility of the compound in aqueous media. Reagent grade, for research purpose.	price>
R-C-2995	Parsaclisib (INCB050465) CAS:1426698-88-5	Parsaclisib (INCB050465) is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP. Parsaclisib inhibits proliferation of several DLBCL and MCL cell lines in vitro (EC50 < 10 nM).Parsaclisib displays significant activity with IC50 values ranging from 0.2 to 2 nM in B and T cell proliferation assays.Only for scientific research, not for human body.	price>
R-R-4665	N-(2-Aminoethyl)-4-[3-(trifluoromethyl)-3H-diazin-3-yl]benzamide CAS:129476-77-3	N-(2-Aminoethyl)-4-[3-(trifluoromethyl)-3H-diazin-3-yl]benzamide CAS:129476-77-3 is a small molecule drug that is composed of several functional groups. The N-(2-aminoethyl) group is a type of amine group that contains a nitrogen atom and is commonly used as a building block for the synthesis of other organic molecules. The 3-(trifluoromethyl)-3H-diazin-3-yl group is a heterocyclic aromatic compound that contains a nitrogen atom and three fluorine atoms. The benzamide group is another type of amide group that contains a nitrogen atom and is commonly used as a building block for the synthesis of other organic molecules.The combination of these functional groups in N-(2-Aminoethyl)-4-[3-(trifluoromethyl)-3H-diazin-3-yl]benzamide is designed to create a drug that can be used to target specific biological processes in the body. The 3-(trifluoromethyl)-3H-diazin-3-yl group, for example, is known to have significant activity against certain types of cancer cells, while the N-(2-aminoethyl) group can help to improve the solubility and stability of the drug in solution.	price>
R-C-2996	740 Y-P cas:1236188-16-1	740 Y-P is a potent and cell permeable PI3K activator.Only for scientific research, not for human body.	price>

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