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Catalog	name	Description	price
R-R-3215	PRX-08066 CAS No.866206-54-4	PRX-08066/CAS No.866206-54-4 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.	price>
R-C-1516	RS1 CAS:312756-74-4	RS-1 is a RAD51 activator,and also increases CRISPR/Cas9-mediated knock-in efficiencies.	price>
R-R-3216	Befiradol CAS No.208110-64-9	Befiradol (NLX-112)/CAS No.208110-64-9 is a selective 5-HT1A receptor agonist.	price>
R-C-1517	C-DIM12 CAS:178946-89-9	C-DIM12 is a novel synthetic activator of Nurr1.C-DIM12 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. C-DIM12 activates Nurr1 in cancer cells and prevents loss of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)model of PD in mice.C-DIM12 induced expression of Nurr1-regulated genes that was abolished by Nurr1 knockdown.C-DIM12 increased expression of transfected human Nurr1,induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA.C-DIM12 stimulates neuroprotective expression Nurr1-regulated genes in DA neurons.	price>
R-R-3217	Melitracen hydrochloride CAS No.10563-70-9	Melitracen hydrochloride/CAS No.10563-70-9 is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space.	price>
R-C-1518	BTZ043 CAS:1161233-85-7	BTZ043 is an inhibitor of decaprenyl-phosphoribose-epimerase(DprE1),with MICs of of 2.3 nM and 9.2 nM for M.tuberculosis H37Rv and Mycobacterium smegmatis, respectively.	price>
R-R-3218	Piromelatine CAS No.946846-83-9	Piromelatine (Neu-P11)/CAS No.946846-83-9 is a melatonin MT1/MT2 receptor agonist, serotonin 5-HT1A/5-HT1D agonist, and serotonin 5-HT2B antagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potentials. Piromelatine (Neu-P11) also possesses pain-related P2X3, TRPV1, and Nav1.7 channel-inhibition capacities.	price>
R-C-1519	PBTZ169 CAS:1377239-83-2	Macozinone(PBTZ169)is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2-oxidase)inhibitor.	price>
R-R-3219	Geissoschizine methyl ether CAS No.60314-89-8	Geissoschizine methyl ether/CAS No.60314-89-8, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is potent 5-HT1A receptor agonist.	price>
R-C-1520	TMS CAS:24144-92-1	TMS is a potent,selective and competitive inhibitor of cytochrome P450 1B1,an enzyme overexpressed in certain tumors(IC50=6 nM).5N/A-and 520-fold selective over P450 1A1 and 1A2 respectively.	price>
R-R-3220	Tianeptine CAS No.72797-41-2	Tianeptine/CAS No.72797-41-2 is a selective facilitator of 5-HT uptake. Tianeptine has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50>10 μM) and has no effect on noradrenalin or dopamine uptake. Tianeptine has antidepressant, anxiolytic, analgesic and neuroprotective activities.	price>
R-C-1521	Compound 401 CAS：168425-64-7	Compound 401 is a synthetic inhibitor of DNA-PK(IC50=0.28 μM) and mTOR(IC50=5.3μM).It has no inhibition on p110α/p85α PI3K(>100 μM) and blocks the phosphorylation of S6 kinase 1 Thr389 and Akt Ser473 in COS7 cells.	price>
R-R-3221	MK-212 monohydrochloride CAS No.61655-58-1	MK-212 (CPP) monohydrochloride/CAS No.61655-58-1 is a centrally acting 5-HT1C/5-HT2 agonist. MK-212 monohydrochloride can stimulate phosphoinositide hydrolysis in cerebral cortex.	price>
R-C-1522	SMER28 CAS：307538-42-7	SMER28 is a small-molecule enhancer(SMER)of autophagy,inducing autophagy independently of rapamycin in mammalian cells.	price>
R-R-3222	Vabicaserin hydrochloride CAS No.887258-94-8	Vabicaserin hydrochloride/CAS No.887258-94-8 is a 5-hydroxytryptamine 2C (5-HT2C) receptor-selective agonist with an EC50 of 8 nM.	price>
R-C-1523	AZ876 CAS:898800-26-5	AZ876 is a potent and high-affinity LXR agonist.AZ876 displays 25-fold and 2.5-fold more potent than GW3965(HY-10627)on human(h)LXRα and hLXRβ respectively.	price>
R-R-3223	Quipazine dimaleate CAS No.150323-78-7	Quipazine dimaleate/CAS No.150323-78-7 is a 5-HT agonist with a Ki value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine dimaleate shows antiviral activity against SARS-CoV-2 with an EC50 of 31.64 μM. Quipazine dimaleate behaves as a 5-HT3R antagonist in peripheral models. Quipazine dimaleate can be used for neurological disease research.	price>
R-C-1524	Paxalisib (GDC-0084) CAS:1382979-44-3	Paxalisib(GDC-0084,RG7666)is a brain penetrant inhibitor of PI3K and mTOR with Kiapp values of 2 nM,46 nM,3 nM,10 nM and 70 nM for PI3Kα,PI3Kβ,PI3Kδ,PI3Kγ and mTOR.	price>
R-R-3224	Desmethyl cariprazine CAS No.839712-15-1	Desmethyl cariprazine/CAS No.839712-15-1 is an active metabolite of Cariprazine. Cariprazine, an antipsychotic agent candidate, exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).	price>
R-C-1525	CWHM-12 CAS:1564286-55-0	CWHM 12 can suppress all 5 alpha V integrins.CWHM12 not only worked the same way to prevent fibrosis as the genetic deletion method,it also prevent the progression of existing fibrosis in the liver and lungs and reversed some of the damage caused by fibrosis to those organs.	price>

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