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Catalog	name	Description	price
R-C-1362	prt4165 CAS No. 31083-55-3	PRT4165 is a small molecule inhibitor of polycomb repressive complex 1,which inhibits ubiquitin signaling at DNA double-strand breaks.PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation in vivo and in vitro.The drug also inhibits the accumulation of all detectable ubiquitin at sites of DNA double-strand breaks(DSBs),the retention of several DNA damage response proteins in foci that form around DSBs,and the repair of the DSBs.	price>
R-R-3062	Atranorin CAS No.479-20-9	Atranorin/CAS No.479-20-9 is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity.	price>
R-C-1363	Finafloxacin Hydrochloride CAS：209342-41-6	Finafloxacin hydrochloride is used to prepare naphthyridonecarboxylic acid derivatives as drugs for treatment therapy of H.pylori infections and associated gastroduodenal illnesses.	price>
R-R-3063	(S)-JDQ-443 CAS No.2653994-10-4	(S)-JDQ-443/CAS No.2653994-10-4 is an isomer of JDQ-443 (HY-139612). JDQ-443 is an orally active, potent, selective, and covalent KRAS G12C inhibitor (extracted from patent WO2021120890A1). JDQ-443 shows antitumor activity.	price>
R-C-1364	BLZ945 CAS：953769-46-5	BLZ945 is a potent and selective CSF-1R kinase inhibitor.It attenuates the turnover rate of TAMs while increasing the number of CD8+ T cells that infiltrate cervical and breast carcinomas.	price>
R-R-3064	Rac1-IN-3 CAS No.380470-06-4	Rac1-IN-3 (Compound 2)/CAS No.380470-06-4 is a Rac1 inhibitor with an IC50 of 46.1 μM.	price>
R-C-1365	Nosiheptide CAS:56377-79-8	Nosiheptide(Multhiomycin),a thiopeptide antibiotic produced by Streptomyces actuosus,inhibits bacterial protein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core.Nosiheptide has been widely used as a feed additive for animal growth.	price>
R-R-3065	(E/Z)-ZINC09659342 CAS No.591726-26-0	(E/Z)-ZINC09659342/CAS No.591726-26-0 is an inhibitor of Lbc-RhoA interaction.	price>
R-C-1366	NQDI-1 CAS：175026-96-7	NQDI-1 is an inhibitor of ASK1,which attenuates acute ischemic renal injury by modulating oxidative stress and cell death.NQDI-1 was used to study LPS-induced activation and role of ASK1 and p38 in anti-inflammatory cytokine production by macrophages Apoptosis signal-regulating kinase 1(ASK1)is among the signaling events that lead to postischemic cell death.Inhibition of ASK1 pathway protected hearts from ischemic damage.	price>
R-R-3066	KRpep-2d TFA	KRpep-2d (TFA) is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research.	price>
R-C-1367	K858 CAS：72926-24-0	K-858 is a novel inhibitor of mitotic kinesin Eg5 and antitumor agent,induces cell death in cancer cells.K858 blocked centrosome separation,activated the spindle checkpoint,and induced mitotic arrest in cells accompanied by the formation of monopolar spindles.Long-term continuous treatment of cancer cells with K858 resulted in antiproliferative effects through the induction of mitotic cell death,and polyploidization followed by senescence.K858 exhibited potent antitumor activity in xenograft models of cancer,and induced the accumulation of mitotic cells with monopolar spindles in tumor tissues.	price>
R-R-3067	K-Ras G12C-IN-2 CAS No.1629267-75-9	K-Ras G12C-IN-2/CAS No.1629267-75-9 is an irreversible covalent K-Ras G12C inhibitor.	price>
R-C-1368	PFI-4 CAS：900305-37-5	PFI-4 is a potent and selective and cell permeable BRPF1 bromodomain inhibitor (IC50=80nM).Exhibits>100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2(BRD1),BRPF3 and BRD4.	price>
R-R-3068	K-Ras(G12C) inhibitor 9 CAS No.1469337-91-4	K-Ras (G12C) inhibitor 9/CAS No.1469337-91-4 is an allosteric inhibitor of the K-Ras (G12C).	price>
R-C-1369	AZ5104 CAS：1421373-98-9 CAS：1421373-98-9	AZ 5104 is an active,demethylated metabolite of AZD 9291,an irreversible inhibitor of EGFR-sensitizing and T790M resistance mutations(IC50s=15-17nM) that spares the wild-type form of the receptor(IC50=480 nM).1,2,3 AZ 5104 displays a similar overall activity profile as the parent compound.	price>
R-R-3069	Deltarasin hydrochloride CAS No.1613404-76-4	Deltarasin hydrochloride/CAS No.1613404-76-4 is an inhibitor of KRAS-PDEδinteraction with Kd of 38 nM for binding to purified PDEδ.	price>
R-C-1370	RU58841 CAS：154992-24-2	RU-58841 is a new specific topical antiandrogen:a candidate of choice for the treatment of acne,androgenetic alopecia and hirsutism.The potent localized inhibition of sebaceous glands by RU 58841 demonstrates the excellent potential of this compound as a topical drug for the treatment of acne and other androgen-mediated disorders.	price>
R-R-3070	RBC10 CAS No.362503-73-9	RBC10/CAS No.362503-73-9 is an anti-cancer agent. RBC10 inhibits the binding of Ral to its effector RALBP1. RBC10 also inhibits Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines.	price>
R-C-1371	GNF-7 CAS：839706-07-9	GNF-7 is a multikinase inhibitor.GNF-7 is a Bcr-Abl inhibitor,with IC50s of 133 nM and 61 nM for Bcr-AblWT and Bcr-AblT315I,respectively.GNF-7 also possesses inhibitory activity against both ACK1(activated CDC42 kinase 1) and GCK(germinal center kinase)with IC50s of 25 nM and 8 nM,respectively.GNF-7 can be used for the research of hematologic malignancies.	price>
R-R-3071	KRASG12D-IN-2	KRASG12D-IN-2 (compound 28) is a KRASG12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition.	price>

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