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Catalog	name	Description	price
R-R-2996	RM-018 CAS No.2641993-55-5	RM-018/CAS No.2641993-55-5 is a potent, functionally distinct tricomplex KRASG12C active-state inhibitor. RM-018 retains the ability to bind and inhibit KRASG12C/Y96D and could overcome resistance. RM-018 binds specifically to the GTP-bound, active [“RAS(ON)”] state of KRASG12C.	price>
R-C-1297	Ceralasertib (AZD6738) CAS:1352226-88-0	Ceralasertib, also known as AZD6738,is an orally available morpholino-pyrimidine-based inhibitor of ataxia telangiectasia and rad3 related(ATR) kinase,with potential antineoplastic activity.Upon oral administration,ATR kinase inhibitor Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1.This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation,disruption of DNA damage repair,and the induction of tumor cell apoptosis.	price>
R-R-2997	8-CPT-2Me-cAMP sodium CAS No.634207-53-7	8-CPT-2Me-cAMP sodium/CAS No.634207-53-7 is a selective activator of exchange proteins activated by cAMP (Epac), the cAMP sensitive guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-CPT-2Me-cAMP sodium activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50> 10 μM). 8-CPT-2Me-cAMP sodium stimulates Epac-mediated Ca2+ release in pancreatic β-cells in vitro.	price>
R-C-1298	SBI0206965 CAS:1884220-36-3	SBI0206965 is a potent and selective autophagy Kinase ULK1 Inhibitor.Many tumors become addicted to autophagy for survival,suggesting inhibition of autophagy as a potential broadly applicable cancer therapy.SBI-0206965 is a highly selective ULK1 kinase inhibitor in vitro and suppressed ULK1-mediated phosphorylation events in cells,regulating autophagy and cell survival.	price>
R-R-2998	MLS-573151 CAS No.10179-57-4	MLS-573151 (MLS000573151)/CAS No.10179-57-4 is a selective GTPase Cdc42 inhibitor with an EC50 of 2 μM. MLS-573151 is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 and RhoA wild-type. MLS-573151 acts by blocking the binding of GTP to Cdc42.	price>
R-C-1299	SC79 CAS:305834-79-1	SC-79 is an activator of Akt that blocks its membrane translocation while allowing its phosphorylation,in the cytosol,by upstream kinases.SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head.SC-79 injections inhibited alcohol-induced osteonecrosis.Alcohol-induced ONFH is associated with suppression of p-Akt-Ser473 in the Akt/GSK3β/β-catenin signaling pathway in bone mesenchymal stem cells.	price>
R-R-2999	AZA1 CAS No.1071098-42-4	AZA1/CAS No.1071098-42-4 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion.	price>
R-C-1300	TAS-301 CAS:193620-69-8	TAS-301 is a potent and selective constrictive remodeling regulator on renarrowing after balloon overstretch injury of porcine coronary artery.TAS-103 inhibits smooth muscle cell migration and proliferation.TAS-103 inhibits intimal thickening after balloon injury to rat carotid arteries.TAS-301 blocks receptor-operated calcium influx and inhibits rat vascular smooth muscle cell proliferation induced by basic fibroblast growth factor and platelet-derived growth factor.TAS-103 inhibits calcium-dependent signal transduction and cytoskeletal reorganization.	price>
R-R-3000	GGTI298 CAS No.180977-44-0	GGTI298/CAS No.180977-44-0 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, strongly inhibiting the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras, with IC50 values of 3 and > 20 μM in vivo, respectively.	price>
R-C-1301	TP-434 (Eravacycline) CAS：1207283-85-9	TP-434 is a novel,broad-spectrum fluorocycline antibiotic with activity against bacteria expressing major antibiotic resistance mechanisms including tetracycline-specific efflux and ribosomal-protection.	price>
R-R-3001	HJC0197 CAS No.1383539-73-8	HJC0197/CAS No.1383539-73-8 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP.	price>
R-C-1302	cambendazol CAS：26097-80-3	Cambendazol is an antihelmintic that,at a dose of 50 mg/kg/day in mice, eradicates S.ratti adult worms from intestine and S.stercoralis larva from muscle.It inhibits polymerization of microtubules isolated from bovine brain with an IC50 value of 64.2µM.	price>
R-R-3002	CCG-100602 CAS No.1207113-88-9	CCG-100602/CAS No.1207113-88-9 is a specific inhibitor of myocardin-related transcription factor A/serum response factor (MRTF-A/SRF) signaling. CCG-100602 specifically block MRTF-A nuclear localization and thus inhibit the fibrogenic transcription factor SRF.	price>
R-C-1303	CYC-116 CAS：693228-63-6	Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2(VEGFR2),resulting in disruption of the cell cycle,rapid cell death, and the inhibition of angiogenesis.	price>
R-R-3003	ML-097 CAS No.743456-83-9	ML-097 (CID-2160985)/CAS No.743456-83-9 is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, and Rab7.	price>
R-C-1304	IWP-L6 CAS：1427782-89-5	IWP-L6,also known as PORCN Inhibitor III and Wnt Pathway Inhibitor XIX,is a potent inhibitor of PORCN(EC50=0.5 nM).Porcupine is a member of the membrane-bound O-acyltransferase family of proteins.It catalyzes the palmitoylation of Wnt proteins,a process required for their secretion and activity.	price>
R-R-3004	KRA-533 CAS No.10161-87-2	KRA-533/CAS No.10161-87-2 is a potent KRAS agonist. KRA-533 binds to the GTP/GDP binding pocket in the KRAS protein to prevent GTP cleavage, resulting in the accumulation of constitutively active GTP-bound KRAS that triggers both apoptotic and autophagic cell death pathways in cancer cells.	price>
R-C-1305	AV-412 CAS：451493-31-5	AV-412,also known as MP-412,is a second-generation,orally bioavailable dual kinase inhibitor with potential antineoplastic activity.EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2),which may result in the inhibition of tumor growth and angiogenesis,and tumor regression in EGFR/HER2-expressing tumors.This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors.EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization.	price>
R-R-3005	RBC8 CAS No.361185-42-4	RBC8/CAS No.361185-42-4 is a novel small molecule inhibitor of Ral GTPase; has IC50 of 3.	price>
R-C-1306	GFT-505 CAS：923978-27-2	Elafibranor,also known as GFT-505,is a dual PPARα/δagonist.Elafibranoris currently being studied for the treatment of cardiometabolic diseases including diabetes,insulin resistance,dyslipidemia,and non-alcoholic fatty liver disease (NAFLD).	price>

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