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BI-2852 CAS No.2375482-51-0
BI-2852 CAS No.2375482-51-0
| Catalog # | Pkg Size | Price(USD) | Quantity | Buy this product |
|---|---|---|---|---|
| R-R-2961 | 5mg | 330.00 | + Add to cart |
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| R-R-2961 | 10mg | 540.00 | + Add to cart |
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Product description
BI-2852/CAS No.2375482-51-0 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.
| Appearance | N/A |
|---|---|
| Molecular Weight | 517.00 |
| Purity | >90% |
| CAS | 2375482-51-0 |
| Formula | C31H28N6O2 |
| Storage | -20℃, protected from light and moisture |
| Transportation | 4-25℃ temperature for up to 2 weeks |
| Stability | 1 year |
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