Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-R-2532	UNC926 CAS No.1184136-10-4	UNC926/CAS No.1184136-10-4 is a methyl-lysine (Kme) reader domain inhibitor that inhibits L3MBTL1 with an IC50 of 3.9 μM.	price>
R-R-2533	TMX1	TMX1 is a BRD4 covalent molecular glue degrader. TMX1 selectively recruits DCAF16 to BRD4BD2, resulting in the degradation of BRD4.	price>
R-C-834	PLGA5000-PEI1800-PEG2000	In order to reduce the influence of acidic microenvironment on protein drugs in PLGA microspheres and improve the stability and bioavailability of protein drugs during storage and administration,it is necessary to use a cationic polymer with low cytotoxicity and good biocompatibility as a buffer material for microenvironment acidification of PLGA microspheres.Pei-peg,a water-soluble cross-linking compound formed by the cross-linking of low molecular weight pei1800 and PEG2000,has been reported to have the advantage of low cytotoxicity.	price>
R-R-2534	Naphthol AS-E CAS No.92-78-4	Naphthol AS-E/CAS No.92-78-4 is a potent and cell-permeable inhibitor of KIX-KID interaction. Naphthol AS-E directly binds to the KIX domain of CBP (Kd:8.6 µM), blocks the interaction between the KIX domain and the KID domain of CREB with IC50 of 2.26 µM. Naphthol AS-E can be used for cancer research.	price>
R-C-835	PEG10K-PGA6K	The PEG10K-PGA6K provided by Ruixibio is a customized synthetic reagent.PEG was grafted onto polyglutamic acid with molecular weights of 1K,2K,5K,10K and 20K, and polyglutamate with molecular weights of 1500,7500,15K,30K,45k and 60K,and the corresponding repeat units of glutamic acid were10,50,100,200,300 and 400, respectively.	price>
R-R-2535	MI-2-2 CAS No.1454920-20-7	MI-2-2/CAS No.1454920-20-7 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (Kd=22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation.	price>
R-C-836	NH2-PEG2K-Dopamine	NH2-PEG2K-Dopamine can be used to modify proteins,peptides and other materials and small molecules with carboxyl(-COOH)or other active groups that can react with primary amines.Amino(-NH2)can easily form stable amide bond with carboxyl group,and can also form amide bond with active ester(-NHS) in ph7-8.5. Polyethylene glycol can increase solubility and stability.It can also inhibit the non-specific binding of charged molecules on the modified surface.	price>
R-R-2536	TPOP146 CAS No.2018300-62-2	TPOP146/CAS No.2018300-62-2 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5.02 μM for CBP and BRD4.	price>
R-C-837	PEG-PAE（200nm）	PAEs poly(β-amino esters) is a kind of hydrophobic polymer,which is often combined with PEG as a amphiphilic copolymer.Peg-b-pae is used to prepare pH responsive micelles.When PAE is in acidic environment,it becomes soluble by protonation of amino groups in the structure.Based on the characteristic of charge transition under acidic condition of PAE,the acidic environment of tumor is used as a signal to trigger PAE to release the encapsulated drug.The main feature of MPEG PAEs is that we can start from the synthetic monomer of PAEs and change its structure,so that the amphiphilic copolymer of MPEG PAEs can destroy its structure and release drugs at different pH values.The pH response range is 5-8,that is,the micelle of MPEG PAEs can respond to ph5-5.3,ph5-5.5,ph6.5-6.8 and weak base 5-8 response.We can also modify various active groups or target molecules,such as folic acid,at the end of PEG.	price>
R-R-2537	M-89 CAS No.2363165-42-6	M-89/CAS No.2363165-42-6 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia.	price>
R-C-838	DSPE-TK-mPEG2K	DSPE-TK-mPEG,DSPE-TK-mPEG2K is a widely used phospholipid polyethylene glycol,which is an attractive amphiphilic lipid polymer conjugate,including hydrophilic peg and extremely hydrophobic fatty acids.In addition,DSPE-PEG is not only widely used as a key self-assembly material for anticancer drug delivery,but also as an additive for surface functionalized drug delivery systems.We can provide peg molecular weights of 1k, 2k, 3.4k, 5k, and 10k for this product.	price>
R-R-2538	Amredobresib CAS No.1610044-98-8	Amredobresib/CAS No.1610044-98-8 is a potent inhibitor of BET. Amredobresib inhibits the binding of bromodomains to acetylated lysines on histone H3 and H4 and thus acts as important regulators of gene transcription. Amredobresib is useful for the research of acute myeloid leukemia (AML) and cancer (extracted from patent WO2019145410A1 and WO2021175824A1).	price>
R-C-839	PCL2K-PEOz2K-COOH	PCL-PEOz,Poly(ε-caprolactone)-Poly(2-ethyl-2-oxazoline)is an amphiphilic AB blockcopolymer,PEOz can As apolymer long chain polymer,PEOz has good water solubility,flexibility andbiocompatibility,PEOzcan completely substitute PEG polyethylene glycol as drug carrier material,PCL-PEOz can be used to prepare PHresponsive micelle for drug delivery。	price>
R-R-2539	FL-411 CAS No.2118944-88-8	FL-411/CAS No.2118944-88-8 is a potent and selective BRD4 inhibitor with an IC50 of 0.43±0.09 μM for BRD4.	price>
R-C-840	Drug entrapment in mesoporous silica(requimod) 50NM	Mesoporous silica nanoparticles (MSNs) have the advantages of uniform particle size distribution,good water dispersion,ultra-high specific surface area,narrow pore size distribution and large pore volume,and good biocompatibility.It can be used as an excellent carrier for fluorescent molecules,chemotherapy drugs,DNA / siRNA,protein and other guest molecules for biomedical applications such as diagnosis.	price>
R-R-2540	PROTAC BET Degrader-1 CAS No.2093386-22-0	PROTAC BET Degrader-1/CAS No.2093386-22-0 is a PROTAC connected by ligands for Cereblon and BET, decreasing BRD2, BRD3, and BRD4 protein levels at low concentration.	price>
R-C-841	Mesoporous silica encapsulated fluorescence (FITC) 50nm	Monodisperse mesoporous silica nanoparticles(MSNs)have the advantages of uniform size distribution,good water dispersibility,ultra-high specific surface area, narrow pore size distribution and large pore volume,and good biocompatibility.It can be used as an excellent carrier for fluorescent molecules,chemotherapy drugs, DNA/siRNA,protein and other guest molecules for biomedical applications such as diagnosis and treatment.	price>
R-R-2541	SNIPER(BRD)-1 CAS No.2095244-54-3	SNIPER(BRD)-1/CAS No.2095244-54-3, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively.	price>
R-C-842	PEG44-PCL60-TSPBA	Ruixibio can provide polyphylene glycol poly(ε-caprolactone)-tspbaPEG-PCL can be used in targeted drug research and widely used in protein carrier and ligand crosslinking.Polyethylene glycol polycaprolactone can be made into drug loaded microspheres,microcapsules,vesicles and micelles,which can be used to achieve sustained release and controlled release of drugs.It can also be used as a tissue engineering scaffold material with good hydrophilicity.	price>
R-R-2542	CeMMEC1 CAS No.440662-09-9	CeMMEC1/CAS No.440662-09-9 is an inhibitor of BRD4, and also has high affinity for TAF1, with an IC50 of 0.9 μM for TAF1, and a Kd of 1.8 μM for TAF1 .	price>

465466467468469470 471472473474475