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R-R-1147 TD52 CAS No.1798328-24-1 TD52/CAS No.1798328-24-1, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 has less p-EGFR inhibition and has potent anti-cancer activity. TD52 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. price>
R-PL-0109 PCL-PEG-CHEMS poly(ε-caprolactone)-polyethylene glycol--CHEMS,PCL-PEG-CHEMS from ruixi poly(ε-caprolactone)-polyethylene glycol--CHEMS (PCL-PEG-CHEMS) is a linear A-B-C type amphiphilic triblock copolymers. It can be used in preparation of hydrogel for drug encapsulation and drug delivery. price>
R-CMF10050 Fe3O4 Magnetic nanoparticles with FITC coating in water/ Organic Green fluorescein FITC labeled mesoporous silica coated with magnetic nanoparticles can be used as drug carriers,FITC fluorescence can be used for fluorescence tracking imaging,cell sorting,magnetic targeting hyperthermia, magnetic particle contrast agent,etc.,which belong to dual imaging nano materials. price>
R-DS-0054 DSPE-PEG2000-NGF NGF is a kind of polypeptide with various activities,which widely exists in various tissues of animals.It can nourish the injured peripheral nerve and promote regeneration and repair.When the peripheral nerve is injured,its corresponding cell body and axon can use exogenous NGF to transport retrogradely through the injured axon,making NGF reach the corresponding cell body.After the complex process of anabolism,NGF can be extended,It promotes axonal myelination. price>
R-R-1148 Sophocarpine CAS No.6483-15-4 Sophocarpine/CAS No.6483-15-4 is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer. price>
R-PL-0110 PLA-PEG-HZ Poly(D,L-lactide)-polyethylene glycol-Hydrazide PLA-PEG-HZ from ruixi hydrazide PEG derivatives, are one of Nanocs aldehyde or ketone reactive PEG derivatives that can react with oxidized polysaccharides or glycoproteins. Reaction between hydrazide PEG and aldehyde/ketone forms a hydrazone bond which can be further reduced by sodium borohydride (NaBH4) to form a more stable linkage. price>
QY-C-1118 Panobinostat Parobinostat lactate is a drug for the treatment of multiple myeloma.Multiple myeloma (mm) is a kind of malignant plasma cell disease.Its tumor cells originate from plasma cells in bone marrow,and plasma cells are the cells that develop to the final functional stage of B lymphocytes. price>
R-DS-0055 DSPE-PEG-PVTRPPR PVTRPPR was modified on the surface of stealth liposomes,and pvtrppr polypeptide was used as the targeting head group.The drug loaded stealth liposome could target the drug to the tumor blood vessels through the tumor penetrating peptide pvtrppr,and penetrate the whole tumor tissue directly,so as to improve the therapeutic effect of the drug. price>
R-R-1149 M2698 CAS No.1379545-95-5 M2698 (MSC2363318A)/CAS No.1379545-95-5 is an orally active, ATP competitive, selective p70S6K and Akt dual-inhibitor with IC50s of 1 nM for p70S6K, Akt1 and Akt3. M2698 can cross the blood-brain barrier and has anti-cancer activity. price>
R-PL-0111 PLA-PEG-Silane Poly(D,L-lactide)-polyethylene glycol--Silane,PLA-PEG-Silane from ruixi Poly(D,L-lactide)-polyethylene glycol--Silane (PLA-PEG-Silane) is a linear A-B-C type amphiphilic triblock copolymers. It can be used in preparation of hydrogel for drug encapsulation and drug delivery. price>
R-NH-001 5-Aminofluorescein Protein fluorescent labeling reagent.Fluorescent antibody technology for rapid identification of pathogens. price>
R-DS-0056 DSPE-PEG-T7(HAIYPRH) T7(HAIYPRH) is a short peptide screened by phage display technology,which can specifically bind to TfR with a binding constant as high as 10 nmol·L −1. Moreover,due to the different binding sites,endogenous TF will not inhibit, but will promote the binding of T7 modified nanoparticles to TfR.Therefore,T7 is more suitable as a target molecule,and there are many reports on the application of T7 peptide alone. price>
R-R-1150 Afuresertib hydrochloride CAS No.1047645-82-8 Afuresertib hydrochloride (GSK 2110183 hydrochloride)/CAS No.1047645-82-8 is an orally bioavailable, selective, ATP-competitive and potent pan-Akt kinase inhibitor with Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively. price>
R-PL-0112 PLA-PEG-ACRL Poly(D,L-lactide)-polyethylene glycol--Acrylates,PLA-PEG- ACRL from ruixi Poly(D,L-lactide)-polyethylene glycol--Acrylates (PLA-PEG- ACRL) is a linear A-B-C type amphiphilic triblock copolymers. It can be used in preparation of hydrogel for drug encapsulation and drug delivery. price>
QY-C-1014 FITC-PNA Peanut agglutinin FITC conjugate (pna-fitc) was prepared by chemical cross-linking method with peanut agglutinin (PNA) and fluorescein isothiocyanate (FITC) purified by affinity chromatography.The product is soluble in PBS (pH 7.3),protein concentration≥1 mg/ml,and contains stabilizer.It can be used for PNA immunofluorescence detection,flow cytometry, analysis of interaction between biological macromolecules and research of targeted drugs. price>
R-DS-0057 DSPE-PEG-R9 Cell penetrating peptide (CPP) is a kind of short peptide with strong penetration effect on cell membrane,which can promote cell uptake.Liposome modified by CPP can improve the rate of liposome entry into the cell,which is a new direction of targeted drug delivery carrier research. price>
R-R-1151 Cenisertib CAS No.871357-89-0 Cenisertib (AS-703569)/CAS No.871357-89-0 is an ATP-competitive multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3. Cenisertib induces major growth-inhibitory effects by blocking the activity of several different molecular targets in neoplastic mast cells (MC). Cenisertib inhibits tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia. price>
R-PL-0113 PLA-PEG- LA Poly(D,L-lactide)-polyethylene glycol--Lipoic acid, PLA-PEG- LA from ruixi Poly(D,L-lactide)-polyethylene glycol--Acrylates (PLA-PEG- ACRL) is a linear A-B-C type amphiphilic triblock copolymers. It can be used in preparation of hydrogel for drug encapsulation and drug delivery. price>
QY-C-1113 FITC-SBA Soybean agglutinin is one of the main antinutritional factors in soybean, which has a certain inhibitory effect on animal growth.Its content is an important index to evaluate the quality of animal feed.Soybean agglutinin (SBA) mainly exists in the protein bodies of soybean cotyledon cells,which is about 10% of the total soybean protein.The molecular weight of soybean lectin is about 120 kDa.It is one of the main anti nutritional factors in soybean. price>
R-DS-0058 DSPE-PEG-ADH1 Liposomes can passively enter tumor tissue through enhanced retention and retention effect(EPR).Compared with radiotherapy and chemotherapy alone, liposomes have certain clinical treatment advantages.However,the liposome can not reach the target site immediately after injection and stay at the tumor site for a long time. price>