AM-2394 CAS：1442684-77-6

AM-2394 is a potent and selective Glucokinase agonist(GKA),which catalyzes the phosphorylation of glucose to glucose-6-phosphate.AM-2394 activates GK with an EC50 of 60 nM,increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models,and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes.

msds---AM-2394