Product apis-endocrinology-hormones

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Catalog	name	Description	price
R-C-2258	Ailanthone CAS：981-15-7	Ailanthone(AIL,Δ13-Dehydrochaparrinone),a natural anti-hepatocellular carcinoma (HCC)component in Ailanthus altissima,induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27.Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway.Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells.	price>
R-C-1903	TC-G-1008 (GPR39-C3) CAS：1621175-65-2	TC-G-1008 is a GPR39(zinc receptor)agonist(EC50 values are 0.4 and 0.8nM for rat and human receptors respectively).	price>
R-C-2387	Propafenone CAS：54063-53-5	Propafenone(SA-79)is an orally active sodium channel blocking agent and a beta-adrenoceptor(β-adrenergic receptor)antagonist.Propafenone offers a broad spectrum of activity in the treatment of cardiac arrhythmias.	price>
R-C-2405	SR59230A CAS:174689-39-5	SR59230A is a blood-brain barrier penetrating,potent and selective antagonist of β3-adrenergic receptor with IC50 of 40nM,408nM,and 648nM for β3,β1,and β2 receptors,respectively.	price>
R-C-2410	Nadolol CAS:42200-33-9	Nadolol(SQ-11725)is a non-selective and orally active β-adrenergic receptors blocker and is a substrate of organic anion transporting polypeptide 1A2(OATP1A2).Nadolol has the the potential for high blood pressure,angina pectoris and vascular headaches research.	price>
R-C-2415	Nicergoline CAS：27848-84-6	Nicergoline,an ergoline derivative ester of bromonicotinic acid,is a potent, selective and orally active antagonist of α1A-adrenoceptor.Nicergoline has vasodilator effects.Nicergoline also has ameliorative effects on cognitive function in mouse models of Alzheimer is disease.	price>
R-C-2417	Olodaterol (BI 1744) CAS:868049-49-4	Olodaterol(BI 1744)is a long-acting β2-adrenergic receptor agonist that is used as a component of an inhalation(Tiotropium/Olodaterol)for treating patients with chronic obstructive pulmonary disease(COPD).	price>
R-C-2418	Guanabenz CAS:5051-62-7	Guanabenz(Acetate)(BR-750)is an alpha-2 selective adrenergic agonist used as an antihypertensive agent.	price>
R-C-2490	GW-9508 CAS: 885101-89-3	GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40)and GPR120 agonist with pEC50s of 7.32 and 5.46,respectively.GW9508 shows ~100-fold selectivity for GPR40 over GPR120.GW9508 is inactive against other GPCRs,kinases,proteases,integrins and PPARs.GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium(KATP)channels opener. Anti-inflammatory and anti-atherosclerotic activities.	price>
R-C-2529	Apalutamide (ARN-509) CAS：956104-40-8	Apalutamide(ARN-509 and JNJ-56021927)is an androgen receptor antagonist with potential antineoplastic activity.ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus.This prevents binding to and transcription of AR-responsive genes.This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells.	price>

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