Product apis-endocrinology-hormones

Home > products > apis> endocrinology-hormones

Catalog	name	Description	price
R-C-474	Enzalutamide (MDV3100) CAS:915087-33-1	MDV3100 is androgen-receptor inhibitor.Highly recommended inhibitor in AR research.Enzalutamide(MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells.Enzalutamide is shown to increase autophagy.	price>
R-C-517	OC000459 cas:851723-84-7	Timapiprant (OC000459) is a potent,selective,and orally active D prostanoid receptor 2 (DP2,also known as CRTH2) antagonist.Timapiprant (OC000459)potently displaces [3H] PGD2 from human recombinant DP2(Ki=13 nM),rat recombinant DP2(Ki=3 nM),and human native DP2(Ki=4 nM).Timapiprant (OC000459) inhibits mast cell activation of Th2 lymphocytes and eosinophils.	price>
R-C-548	DY131 CAS: 95167-41-2	DY131(GSK 9089) is a potent and selective ERRγ and ERRβ agonist.DY131displays inactive against ERRα,ERα and ERβ.DY131 also inhibits Smo signaling.	price>
R-C-582	LY500307 cas:533884-09-2	Erteberel(LY500307)is a potent and selective estrogen receptor beta(ERβ)agonist with Ki and EC50 of 1.54 nM and 3.61 nM,respectively.Anti-tumor activities.	price>
R-C-624	TAK875 CAS:1000413-72-8	Fasiglifam(TAK-875) is a selective GPR40 agonist with EC50 of 14 nM in human GPR40 expressing CHO cell line,400-fold more potent than oleic acid.	price>
R-C-636	NSC 405020 cas:7497-07-6	NSC 405020 is a novel small molecule inhibitor of MT1-MMP that specifically targets PEX domain rather than the catalytic domain of MT1-MMP with IC50 >100 μM and does not inhibit the catalytic activity of MT1-MMP or MMP-2.	price>
R-C-646	GW9508 cas:885101-89-3	GW 9508 is a cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor(GPCR)GRP40/FFA1 receptor (EC50 ?50 nM)with reduced activity towards family members GRP120 (EC50?3.5 μM), GRP41/GRP43 (EC50>50 μM),as well as a panel of eight other free fatty acid (FFA) and prostaglandin receptors.	price>
R-C-1096	UNBS-5162 CAS: 956590-23-1	UNBS5162 is a pan-antagonist of CXCL chemokine expression with in vitro cytotoxic activity(IC50 range of 0.5-5 µM)against a range of human cancer cell lines including glioblastoma(Hs683 and U373MG),colorectal(HCT-15 and LoVo), non-small-cell lung(A549)and breast(MCF-7).	price>
R-C-1103	AL 082D06 CAS：256925-03-8	AL082D06 is a nonsteroidal glucocorticoid receptor(GR)antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids,androgens,estrogens,and progestins.	price>
R-C-1140	GKT137831 CAS:1218942-37-0	GKT137831,a novel pyrazolopyridinedione derivative,a dual inhibitor of NADPH oxidases(NOX)1 and NOX4,reduces inflammation in the ischemic retina by dampening the pro-inflammatory phenotype of retinal immune cells as well as macroglial Müller cells and neurons.GKT137831 may be of significant benefit for patients with systemic sclerosis as studies in experimental models show that the compound may reduce the abnormal growth of connective tissue(fibrosis)and improve survival.GKT-137831 acts as a Nox4 and Nox1 inhibitor((Ki100-150 nM).GKT-137831 attenuates hypoxia-induced pulmonary vascular cell proliferation.Also a potent inhibitor of fibrosis and hepatocyte apoptosis.	price>

...