Product apis-apoptosis

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Catalog	name	Description	price
R-R-1557	CUR61414 CAS No.334998-36-6	CUR61414/CAS No.334998-36-6 is a novel, potent and cell permeable Hedgehog signaling pathway inhibitor (IC50 =100-200 nM). CUR61414 is a small-molecule aminoproline class compound and selectively binds to smoothened (Smo) with a Ki value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells.	price>
R-R-1558	Forodesine hydrochloride CAS No.284490-13-7	Forodesine hydrochloride (BCX-1777 hydrochloride)/CAS No.284490-13-7 is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine hydrochloride is a potent human lymphocyte proliferation inhibitor. Forodesine hydrochloride could induce apoptosis in leukemic cells by increasing the dGTP levels.	price>
R-R-1560	IACS-010759 hydrochloride CAS No.1807523-99-4	IACS-010759 hydrochlorideis/CAS No.1807523-99-4 an orally active, potent mitochondrial complex I of oxidative phosphorylation (OXPHOS) inhibitor. IACS-010759 hydrochlorideinhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS. IACS-010759 hydrochloride has the potential for relapsed/refractory AML and solid tumors research.	price>
R-R-1561	Forodesine CAS No.209799-67-7	Forodesine (BCX-1777)/CAS No.209799-67-7 is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine could induce apoptosis in leukemic cells by increasing the dGTP levels.	price>
R-R-1562	Indinavir sulfate CAS No.157810-81-6	Indinavir sulfate (MK-639)/CAS No.157810-81-6 is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir sulfate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir sulfate is also a SARS-CoV 3CLpro inhibitor.	price>
R-R-1563	Bullatine A CAS No.1354-84-3	Bullatine A/CAS No.1354-84-3, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A is a potent P2X7 antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses. Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed.	price>
R-R-1564	(Rac)-CCT 250863 CAS No.1364269-06-6	(Rac)-CCT 250863 (compound rac-21)/CAS No.1364269-06-6 is a selective and reversible NEK 2 inhibitor with an IC50 of 0.073 µM. (Rac)-CCT 250863 shows good effects of inducing cell cycle arrest and also can antiproliferative in cells (Pomalidomide sensitive/resistant). (Rac)-CCT 250863 induces apoptosis when combines with Pomalidomide.	price>
R-R-1565	NSC 48160 CAS No.6640-90-0	NSC 48160/CAS No.6640-90-0 inhibits the growth of the pancreatic cancer cells with IC50s of 84.3 μM for CPFAC-1 and 94.5 μM for BxPC-3. NSC 48160 also induces pancreatic cancer cell apoptosis. NSC 48160 can improve metabolic syndromes, such as NASH, obesity and lipid metabolism disorders.	price>
R-R-1566	Cantrixil CAS No.2135511-22-5	Cantrixil (TRX-E-002-1)/CAS No.2135511-22-5, an active enantiomer of TRX-E-002, is a second-generation super-benzopyran (SBP) compound. Cantrixil increases phosphorylated c-Jun levels resulting in caspase-mediated apoptosis in ovarian cancer cells. Cantrixil has potent pan anti-cancer activity against a broad range of cancer phenotypes.	price>
R-R-1567	GSK-843 CAS No.1601496-05-2	GSK-843/CAS No.1601496-05-2 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM. GSK-843 can be used for the research of inflammation.	price>

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