Product apis-apoptosis

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Catalog	name	Description	price
R-R-1494	WM-3835 CAS No.2229025-70-9	WM-3835/CAS No.2229025-70-9 is a potent and high-specific HBO1 (KAT7 or MYST2) inhibitor and binds directly to the acetyl-CoA binding site of HBO1 33. WM-3835 activates apoptosis while inhibits osteosarcoma (OS) cell proliferation, migration and invasion. WM-3835 has antitumor activity and potently inhibits pOS-1 xenograft growth in mice.	price>
R-R-1495	pan-HER-IN-2 CAS No.1639040-95-1	pan-HER-IN-2 (Compound C6)/CAS No.1639040-95-1 is a reversible, orally active pan-HER inhibitor with IC50 values of 0.72, 2.0, 8.2 and 75.1 nM against EGFR, HER4, EGFRT790M/L858R and HER2, respectively. pan-HER-IN-2 induces apoptosis and shows antitumor activities.	price>
R-R-1496	2-Methoxycinnamaldehyde CAS No.1504-74-1	2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde)/CAS No.1504-74-1 is a natural compound of Cinnamomum cassia, with antitumor activity. 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (ΔΨm) loss, activation of both caspase-3 and caspase-9. 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration.	price>
R-R-1497	Flavokawain B CAS No.1775-97-9	Flavokawain B (Flavokavain B)/CAS No.1775-97-9 is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations.	price>
R-R-1498	NHWD-870 CAS No.2115742-03-3	NHWD-870/CAS No.2115742-03-3 is a potent, orally active and selective BET family bromodomain inhibitor and only binds bromodomains of BRD2, BRD3, BRD4 (IC50=2.7 nM), and BRDT. NHWD-870 has potent tumor suppressive efficacies and suppresses cancer cell-macrophage interaction. NHWD-870 increases tumor apoptosis and inhibits tumor proliferation.	price>
R-R-1499	Mevastatin CAS No.73573-88-3	Mevastatin (Compactin)/CAS No.73573-88-3 is a first HMG-CoA reductase inhibitor that belongs to the statins class. Mevastatin is a lipid-lowering agent, and induces apoptosis, arrests cancer cells in G0/G1 phase. Mevastatin also increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels. Mevastatin has antitumor activity and has the potential for cardiovascular diseases treatment.	price>
R-R-1500	KRCA-0008 CAS No.1472795-20-2	KRCA-0008/CAS No.1472795-20-2 is a selective ALK/Ack1 inhibitor with IC50s of 12 and 4 nM for ALK and Ack1, respectively. KRCA-0008 can be used for the research of cancer.	price>
R-R-1501	MS1943 CAS No.2225938-17-8	MS1943/CAS No.2225938-17-8 is a first-in-class, orally bioavailable EZH2 selective degrader, with an IC50 of 120 nM. MS1943 significantly reduces EZH2 protein levels in numerous triple-negative breast cancer (TNBC) and other cancer and noncancerous cell lines. MS1943 effectively blocks proliferation of multiple TNBC and other cancer cell lines.	price>
R-R-1502	Alteminostat CAS No.1246374-97-9	Alteminostat (CKD-581)/CAS No.1246374-97-9 is a potent HDAC inhibitor. Alteminostat inhibits the class I-II HDAC family via histone H3 and tubulin acetylation. Alteminostat can be used for lymphoma and multiple myeloma research.	price>
R-R-1503	Prinomastat CAS No.192329-42-3	Prinomastat (AG3340)/CAS No.192329-42-3 is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9, respectively. Prinomastat inhibits MMP-2, MMP-3 and MMP-9 with Kis of 0.05 nM, 0.3 nM and 0.26 nM, respectively. Prinomastat crosses blood-brain barrier. Antitumor avtivity.	price>

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