Product apis-apoptosis

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Catalog	name	Description	price
R-R-1484	(Z)-Guggulsterone CAS No.39025-23-5	(Z)-Guggulsterone/CAS No.39025-23-5, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis. (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection.	price>
R-R-1485	Verrucarin A CAS No.3148-09-2	Verrucarin A (Muconomycin A)/CAS No.3148-09-2, a Type D macrocyclic mycotoxin derived from the pathogen fungus Myrothecium verrucaria, is an inhibitor of protein synthesis. Verrucarin A inhibits growth of leukemia cell lines and activates caspases and apoptosis and inflammatory signaling in macrophages. Verrucarin A effectively increased the phosphorylation of p38 MAPK and diminished the phosphorylation of ERK/Akt. Verrucarin A caused cell cycle deregulation through the induction of p21 and p53.	price>
R-R-1486	Colivelin TFA CAS No.2803948-60-7	Colivelin TFA/CAS No.2803948-60-7 is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro. Colivelin TFA exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease.	price>
R-R-1487	Citric acid-13C3 CAS No.302912-06-7	Citric acid-13C3/CAS No.302912-06-7 is the 13C labeled Citric acid. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice.	price>
R-R-1488	Propylparaben-d4 CAS No.1219802-67-1	Propylparaben-d4/CAS No.1219802-67-1 is the deuterium labeled Propylparaben. Propylparaben (Propyl parahydroxybenzoate) is an antimicrobial preservative which can be produced naturally by plants and bacteria. Propylparaben is prevalently used in cosmetics, pharmaceuticals, and foods. Propylparaben disrupts antral follicle growth and steroidogenic function by altering the cell-cycle, apoptosis, and steroidogenesis pathways. Propylparaben also decreases sperm number and motile activity in rats.	price>
R-R-1489	S65487 hydrochloride CAS No.1644543-95-2	S65487 (VOB560) hydrochloride/CAS No.1644543-95-2, a potent and selective Bcl-2 inhibitor, is a proagent of S55746. S65487 hydrochloride is also active on BCL-2 mutations, such as G101V and D103Y. S65487 hydrochloride has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 hydrochloride induces apoptosis and has anticaner activities.	price>
R-R-1490	Coniferaldehyde CAS No.458-36-6	Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde)/CAS No.458-36-6 is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities.	price>
R-R-1491	Prexasertib CAS No.1234015-52-1	Prexasertib (LY2606368)/CAS No.1234015-52-1 is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. Prexasertib inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib shows potent anti-tumor activity.	price>
R-R-1492	Inecalcitol CAS No.163217-09-2	Inecalcitol (TX 522)/CAS No.163217-09-2, a unique vitamin D3 analog, is an orally active vitamin D receptor (VDR) agonist with a Kd of 0.53 nM. Inecalcitol can induce cell apoptosis and has potent anticancer activities. Inecalcitol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-R-1493	Aeroplysinin 1 CAS No.28656-91-9	Aeroplysinin 1 ((+)-Aeroplysinin-1)/CAS No.28656-91-9, a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells.	price>

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