Product apis-angiogenesis

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Catalog	name	Description	price
R-C-1891	Acalabrutinib（ACP-196） CAS:1420477-60-6	Acalabrutinib(ACP-196)is a selective second-generation Bruton is tyrosine kinase(BTK)inhibitor with an IC50 of 3nM,which prevents the activation of the B-cell antigen receptor(BCR)signaling pathway.ACP-196 has improved target specificity over ibrutinib with 323-,94-,19-and 9-fold selectivity over the other TEC kinase family members(ITK,TXK,BMX,and TEC,respectively)and no activity against EGFR.	price>
R-C-1894	Nazartinib(EGF816) CAS：1508250-71-2	Nazartinib(EGF816,NVS-816)is a covalent,irreversible,mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt(L858R,ex19del)and T790M mt,with up to 60-fold selectivity over wild type(wt)EGFR in vitro.	price>
R-C-1923	MK-8617 CAS：1187990-87-9	MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3(HIF PHD1-3)with an IC50 of 1nM for PHD2.	price>
R-C-1984	Erdafitinib (JNJ-42756493) CAS：1346242-81-6	Erdafitinib(JNJ-42756493)is a potent and selective orally bioavailable,pan fibroblast growth factor receptor(FGFR)inhibitor with potential antineoplastic activity.JNJ-42756493 binds to and inhibits FGFR,which may result in the inhibition of FGFR-related signal transduction pathways and thus the inhibition of tumor cell proliferation and tumor cell death in FGFR-overexpressing tumor cells.FGFR,upregulated in many tumor cell types,is a receptor tyrosine kinase essential to tumor cell proliferation, differentiation and survival.	price>
R-C-1992	Fruquintinib (HMPL-013) CAS:1194506-26-7	Fruquintinib is an orally available,small molecule inhibitor of vascular endothelial growth factor receptors(VEGFRs),with potential anti-angiogenic and antineoplastic activities.	price>
R-C-2039	TAS6417 CAS：1661854-97-2	TAS6417(CLN-081)is a highly effective,orally active and pan-mutation-selective EGFR tyrosine kinase inhibitor with a unique scaffold fitting into the ATP-binding site of the EGFR hinge region,with IC50 values ranging from 1.1-8.0 nM.	price>
R-C-2060	PRT062607 (P505-15) HCl CAS :1370261-97-4	PRT062607(P505-15,BIIB057,PRT-2607)HCl is a novel,highly selective Syk inhibitor with IC50 of 1 nM in cell-free assays,>80-fold selective for Syk than Fgr,PAK5,Lyn,FAK,Pyk2,FLT3,MLK1 and Zap70.	price>
R-C-2066	ODM-203 CAS：1430723-35-5	ODM-203 is a potent FGFR and VEGFR families inhibitor with IC50s of 11,16,6,35nM towards recombinant FGFR1,FGFR2,FGFR3 and FGFR4 as well as 26,9,5 nM towards VEGFR1,VEGFR2 and VEGFR3,respectively.	price>
R-C-2188	Dasatinib (BMS-354825) CAS:302962-49-8	Dasatinib(BMS-354825)is an oral multi-BCR/ABL and Src family tyrosine kinase inhibitor.The main targets of dasatinib,are BCR/ABL,Src,c-Kit,ephrin receptors, and several other tyrosine kinases,but not erbB kinases such as EGFR or Her2.	price>
R-C-2189	XL228 CAS:898280-07-4	XL228 is a protein kinase inhibitor targeting IGF1R,the AURORA kinases,FGFR1-3, ABL and SRC family kinases.XL228 is an Aurora A inhibitor(IC50,f3 nmol/L)that has shown potent biochemical activity against ABL1(Ki,5 nmol/L)as well as the BCR-ABL1 T315I(Ki,1.4 nmol/L)kinases.	price>

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