Catalog name Description price
R-C-441 DMXAA(AS1404,ASA404) DMXAA is an apoptosis inducer,and an anti-vascular.DMXAA is an inhibitor of NQO1, Flk-1 and Flt-1. price>
R-C-493 PCI-32765 cas:936563-96-1 Ibrutinib (PCI-32765) is a potent and highly selective Brutons tyrosine kinase (Btk)inhibitor with IC50 of 0.5 nM in cell-free assays,modestly potent to Bmx, CSK,FGR,BRK,HCK,less potent to EGFR Yes,ErbB2,JAK3etc.Ibrutinib is applicable as a Btk ligand in the synthesis of a series of PROTACs including P13I. price>
R-C-494 AP24534(Ponatinib) cas:943319-70-8 Ponatinib(AP24534)is a novel,potent multi-target inhibitor of Abl,PDGFRα, VEGFR2,FGFR1 and Src with IC50 of 0.37 nM,1.1 nM,1.5 nM,2.2 nM and 5.4 nM in cell-free assays,respectively.Ponatinib (AP24534) inhibits autophagy. price>
R-C-495 AT101 CAS:90141-22-3 AT101,the R-(-) enantiomer of Gossypol acetic acid,binds with Bcl-2,Bcl-xL and Mcl-1 with Ki of 0.32μM,0.48μM and 0.18μM. price>
R-C-514 PF-562771 cas:834894-21-2 AP23464 and PF-562771(AP23848) potently and selectively target activation-loop mutants of Kit in vitro and in vivo and could have therapeutic potential against D816V-expressing malignancies.Src/Abl inhibitors are compatible with imatinib and suggest that combined Abl inhibitor therapy is a feasible treatment strategy for patients with CML. price>
R-C-526 IOX2 cas:931398-72-0 IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2(PHD2) with IC50 of 21 nM in a cell-free assay,100-fold selectivity over JMJD2A,JMJD2C,JMJD2E,JMJD3,or the 2OG oxygenase FIH. price>
R-C-527 GNF-2 cas:778270-11-4 GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl,shows no activity to Flt3-ITD,Tel-PDGFR,TPR-MET and Tel-JAK1 transformed tumor cells. price>
R-C-535 R788 cas:901119-35-5 R788(Fostamatinib)is an important spleen tyrosine kinase(Syk)inhibitor,showing efficacy against kinase-mediated IgG Fc gamma receptor signaling. price>
R-C-550 Pyridone 6 CAS:457081-03-7 Pyridone 6(CMP 6)is a potent and selective inhibitor of JAK1 (IC50=15 nM,murine JAK1),JAK2 (IC50=1 nM),JAK3 (Ki=5 nM),and Tyk2 (IC50=1 nM);displaying significantly weaker affinities (130 nM to 10 mM) for other protein tyrosine kinases. price>
R-C-619 PD173074 cas:219580-11-7 PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays,~1000-fold selective for FGFR1 than PDGFR and c-Src.PD173074 reduces proliferation and promotes apoptosis in gastric cancer cells. price>