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Catalog	name	Description	price
R-R-4591	ML-60218 CAS No.577784-91-9	ML-60218/CAS No.577784-91-9 is a broad-spectrum RNA pol III inhibitor, with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and to hamper the formation of new ones without the need for de novo transcription of cellular RNAs.	price>
R-C-2922	PAMAM-PLA-Protected amines(Fmoc, tBOC)	Polyamide amine dendrimer (PAMAM) is one of the earliest synthesized dendrimers. It is monodisperse, with a cavity inside and a high-density amine group on the surface. Dendrimers link PLA and PLA links ammonia.	price>
R-R-4592	Simeprevir CAS No.923604-59-5	Simeprevir (TMC435; TMC435350)/CAS No.923604-59-5 is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses.	price>
R-C-2923	PAMAM-PCL-ACRL	Polyamide amine dendrimer (PAMAM) is one of the earliest synthesized dendrimers. It is monodisperse, with a cavity inside and a high-density amine group on the surface. PCL has good biocompatibility, good organic polymer compatibility and good biodegradability. It can be used as cell growth support material and compatible with a variety of conventional plastics.	price>
R-R-4593	BAY-2402234 CAS No.2225819-06-5	BAY-2402234/CAS No.2225819-06-5 is a selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies.	price>
R-C-2924	PS-b-PBd	Polybutadiene is mainly used as synthetic rubber. Solution polymerized polybutadiene is often used together with styrene butadiene rubber or natural rubber as tread and carcass of tires. Polystyrene resin, English name is poly (styrene), molecular formula is C8H8, general type (R) is suitable for packaging materials; Flame retardant (f) is suitable for building and thermal insulation materials.	price>
R-R-4594	5-Fluorouridine CAS No.316-46-1	5-Fluorouridine/CAS No.316-46-1, a metabolite of 5-fluorouracil (HY-90006), is a potent ribozyme self-cleavage inhibitor. 5-Fluorouridine incorporates into both total and poly A RNA and has antiproliferative activity. 5-Fluorouridine induces apoptosis.	price>
R-C-2925	PDPA5K	Block copolymer micelles are usually formed by self-assembly of amphiphilic block copolymers in aqueous media.Hydrophilic and hydrophobic blocks form shell and core micelles,respectively.Methoxypolyethylene glycol(MPEG)-b-Poly(2-diisopropylamino)ethyl methacrylate(PDPA)block copolymer was synthesized by atom transfer radical polymerization of 2-bromoisobutyl bromide and MPEG in the presence of triethylamine catalyst.	price>
R-R-4595	NSC 617145 CAS No.203115-63-3	NSC 617145/CAS No.203115-63-3 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC50 value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases.	price>
R-C-2926	PS-b-P4VP-b-PAA	The formation of block copolymer micelles depends on the attraction of hydrophobic end and the repulsion of hydrophilic end. According to the law of thermodynamics, when the surface free energy of the core-shell interface is smaller, the micelle is more stable. At this time, the micelle shrinks, the interfacial area shrinks, and the spatial repulsion force at the hydrophilic end increases; The interfacial tension and spatial repulsion restrict each other, so that the micelles can not aggregate or relax indefinitely to form a micellar system with stable particle size.	price>
R-R-4596	IMP-1088 CAS No.2059148-82-0	IMP-1088/CAS No.2059148-82-0 is a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC50s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 has a Kd of <210 pM for HsNMT1. IMP-1088 efficiently blocks rhinovirus replication by blocking rhinovirus virus-encoded protein (VP0) N-myristoylation. IMP-1088 protects host cells from the cytotoxic effects of viral infection.	price>
R-C-2927	AC-TPE	Tetraphenylethylene molecules with strong fluorescence emission characteristics have attracted more and more research attention because of their wide application prospects in the fields of optoelectronic materials, biological detection, chemical sensing and so on.	price>
R-R-4597	CX-5461 dihydrochloride	CX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 ≥25 μM).	price>
R-C-2928	Bilirubin-Polyethylene glycol-Sialic acid	Sialic acid is a derivative of 9-carbon monosaccharide, a negatively charged ion that can make saliva feel smooth. Polyethylene glycol has good water solubility and good miscibility with many organic components. They have excellent lubricity, moisture retention, dispersibility, adhesives, antistatic agents and softeners	price>
R-R-4598	Tirapazamine CAS No.27314-97-2	Tirapazamine (SR259075)/CAS No.27314-97-2 is an anticancer agent that shows selective cytotoxicity for hypoxic cells in solid tumors, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. Tirapazamine is an anticancer and bioreductive agent.Tirapazamine (SR259075) can enhance the cytotoxic effects of ionizing radiation in hypoxic cells.	price>
R-C-2929	PEI-Ortho bromophenylboronic acid	Polyethyleneimine has high reaction activity, can react with hydroxyl groups in cellulose and crosslink polymerization, so as to produce wet strength of paper. The presence of any acid, alkali and aluminum sulfate will affect its wet strength and retention.	price>
R-R-4599	RP-6685 CAS No.2832047-80-8	RP-6685/CAS No.2832047-80-8 is a potent, selective and orally active DNA polymerase theta (Polθ) inhibitor with an IC50 value of 5.8 nM (PicoGreen assay). RP-6685 shows antitumor efficacy in mouse tumor xenograft model. RP-6685 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-R-4600	D-I03 CAS No.688342-78-1	D-I03/CAS No.688342-78-1 is a selective RAD52 inhibitor with a Kd of 25.8 µM. D-I03 specifically inhibits RAD52-dependent single-strand annealing (SSA) and D-loop formation with IC50s of 5 µM and 8 µM, respectively. D-I03 suppresses growth of BRCA1- and BRCA2-deficient cells and inhibits formation of damage-induced RAD52 foci, but does not effect on RAD51 foci induced by Cisplatin.	price>
R-C-2931	FITC modified silica nanoparticles（50nm）	FITC modified silica nanoparticles, green fluorescence, particle size 50 nm, dispersed in ultrapure water. 5mg/ml.	price>
R-R-4601	Quarfloxin CAS No.865311-47-3	Quarfloxin (CX-3543)/CAS No.865311-47-3, a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template.	price>

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