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Catalog	name	Description	price
R-C-2722	CP-724714 CAS:537705-08-1	CP-724714 is a potent,selective and orally active ErbB2(HER2)tyrosine kinase inhibitor,with an IC50 of 10nM.CP-724714 displays a marked selectivity against EGFR kinase(IC50=6400nM).CP-724714 potently inhibits ErbB2 receptor autophosphorylation in intact cells.Antitumor activities.	price>
R-R-4422	ML401 CAS No.1597489-14-9	ML401/CAS No.1597489-14-9, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity.	price>
R-C-2723	AC480 (BMS-599626) CAS:714971-09-2	BMS-599626(AC480)is a selective and orally bioavailable HER1 and HER2 inhibitor,with IC50s of 20 and 30nM,respectively.BMS-599626 displays~8-fold less potent to HER4(IC50=190nM),>100-fold to VEGFR2,c-Kit,Lck,MEK. BMS-599626 inhibits tumor cell proliferation,and has potential to increase tumor response to radiotherapy.	price>
R-R-4423	SAE-14 CAS No.1241280-25-0	SAE-14 (compound SAE-14)/CAS No.1241280-25-0 is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice.	price>
R-C-2724	Corylifol A CAS:775351-88-7	Corylifol A is a phenolic compounds isolated from Psoralea corylifolia;inhibits IL-6-induced STAT3 activation and phosphorylation(IC50=0.8uM).	price>
R-R-4424	GPR183 antagonist-2 CAS No.2924063-98-7	GPR183 antagonist-2 (compound 32)/CAS No.2924063-98-7 is a selective GPR183 antagonist with good water solubility and excellent pharmacokinetic properties. GPR183 antagonist-2 significantly reduces paw and joint swelling and gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a collagen-induced arthritis (CIA) mouse model in a dose-dependent manner. GPR183 antagonist-2 can be used in the study of autoimmune diseases.	price>
R-C-2725	BMS-690514 CAS:859853-30-8	BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor(EGFR),HER2,and HER4，as well as the VEGF receptor kinases.	price>
R-R-4425	AZD1390 CAS No.2089288-03-7	AZD1390/CAS No.2089288-03-7 is a potent, highly selective, orally bioavailable, brain-penetrant ATM inhibitor with an IC50 of 0.78 nM in cell.	price>
R-R-4426	Camonsertib CAS No.2417489-10-0	Camonsertib (RP-3500)/CAS No.2417489-10-0 is an orally active, selective ATR kinase inhibitor (ATRi) with an IC50 of 1.00 nM in biochemical assays. Camonsertib shows 30-fold selectivity for ATR over mTOR (IC50=120 nM) and >2,000-fold selectivity over ATM, DNA-PK, and PI3Kα kinases. Camonsertib has potent antitumor activity.	price>
R-C-2727	GSK 0660 CAS：1014691-61-2	GSK 0660 is a selective PPARβ antagonist(IC50 values are 0.155,>10 and≥10µM at PPARβ,PPARα and PPARγ respectively).	price>
R-R-4427	Elimusertib hydrochloride	Elimusertib (BAY 1895344) hydrochloride is a potent, orally active and selective ATR inhibitor with an IC50 of 7 nM. Elimusertib hydrochloride has anti-tumor activity. Elimusertib hydrochloride can be used for the research of solid tumors and lymphomas.	price>
R-C-2728	Zardaverine CAS：101975-10-4	Zardaverine is a newly developed dual-selective PDE3/4 inhibitor with IC50 values of 0.5 uM and 0.8uM respectively.	price>
R-R-4428	Gartisertib CAS No.1613191-99-3	Gartisertib (VX-803)/CAS No.1613191-99-3 is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. Gartisertib potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation with an IC50 of 8 nM. Antitumor activity.	price>
R-C-2729	PF-04457845 CAS:1020315-31-4	PF-04457845 is a highly efficacious and selective FAAH inhibitor with IC50 values is 7.2±0.63nM and 7.4±0.62nM for hFAAH and rFAAH,respectively.	price>
R-R-4429	Tuvusertib CAS No.1613200-51-3	Tuvusertib (M1774; ATR inhibitor 1)/CAS No.1613200-51-3 is a selective and orally active ATR inhibitor extracted from patent WO2015187451A1, compound I-l, with a Ki value below 1 μΜ.	price>
R-C-2730	MK-8245 CAS:1030612-90-8	MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD)with IC50 of 1 nM for human SCD1 and 3nM for both rat SCD1 and mouse SCD1,with anti-diabetic and anti-dyslipidemic efficacy.Phase 2.	price>
R-R-4430	Lartesertib CAS No.2495096-26-7	Lartesertib (M4076)/CAS No.2495096-26-7 is a potent inhibitor of serine/threonine protein kinase ATM (extracted from patent WO2022058351A1).	price>
R-C-2731	ABT-046 CAS:1031336-60-3	ABT-046 is a potent,selective,and orally efficacious acyl CoA:diacylglycerol acyltransferase 1(DGAT-1)inhibitor(IC50=8nM).	price>
R-R-4431	Ro 90-7501 CAS No.293762-45-5	Ro 90-7501/CAS No.293762-45-5 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells.	price>
R-C-2732	CS@Fe3O4 nanoparticles	The product is 30nm chitosan coated Fe3O4 magnetic nanoparticles with a large number of active amino groups on the surface and a saturation magnetization of 70-80.	price>

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