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Catalog	name	Description	price
R-C-2786	Mizolastine CAS:108612-45-9	Mizolastine is a histamine H1-receptor antagonist with IC50 of 47nM used in the treatment of hay fever(seasonal allergic rhinitis),hives and other allergic reactions.	price>
R-R-4486	AMG-548 dihydrochloride CAS No.2518299-32-4	AMG-548 dihydrochloride/CAS No.2518299-32-4, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 dihydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM). AMG-548 dihydrochloride inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε.	price>
R-C-2787	BP 554 maleate CAS:1221401-95-1	BP-554 maleate is a selective agonist of 5-HT1A receptor.BP-554 maleate is a selective 5-HT1A receptor agonist.BP-554 showed higher affinity for 5-HT1A receptor than for 5-HT1-non-A,5-HT2,α2-adrenergic,dopamine D2 and benzodiazepine receptors.	price>
R-R-4487	CK1-IN-1 CAS No.1784751-20-7	CK1-IN-1/CAS No.1784751-20-7 is a casein kinase 1 (CK1) inhibitor extracted from patent WO2015119579A1, compound 1c, has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MAPK, respectively.	price>
R-C-2788	MFZ 10-7 CAS:1224431-15-5	High affinity negative allosteric modulator at the mGlu5 receptor(Ki=0.67nM).Potently inhibits mGlu5 glutamate-mediated calcium mobilization(IC50=1.22nM).Inhibits cocaine-taking and cocaine-seeking behavior in rats.	price>
R-R-4488	PF-5006739 CAS No.1293395-67-1	PF-5006739/CAS No.1293395-67-1 is a potent and selective inhibitor of CK1δ/ε with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 attenuats opioid agent-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity.	price>
R-C-2789	ATB-346 CAS:1226895-20-0	Otenaproxesul(ATB-346),an orally active non-steroidal anti-inflammatory drug(NSAID),inhibits cyclooxygenase-1 and 2(COX-1 and 2).Otenaproxesul possesses antiinflammatory and antinociceptive activities.	price>
R-R-4489	BTX161 CAS No.2052301-24-1	BTX161/CAS No.2052301-24-1, a Thalidomide analog, is a potent CKIα degrader. BTX161 mediates degradation of CKIα better than Lenalidomide in human AML cells and activates DNA damage response (DDR) and p53, while stabilizing the p53 antagonist MDM2.	price>
R-C-2790	AZD3839 CAS:1227163-84-9	AZD3839 free base is a potent and selective orally active,brain-permeable BACE1 inhibitor(Ki=26nM).AZD3839 free base shows 14 and>1000-fold selectivity against BACE2 and cathepsin D,respectively.AZD3839 free base exhibits dose-and time-dependent lowering of plasma,brain,and cerebrospinal fluid Aβ levels in mouse,guinea pig,and non-human primate.	price>
R-R-4490	CK2/ERK8-IN-1 CAS No.1085822-09-8	CK2/ERK8-IN-1/CAS No.1085822-09-8 is a dual casein kinase 2 (CK2) (Ki of 0.25 µM) and ERK8 (MAPK15, ERK7) inhibitor with IC50s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with Kis of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy.	price>
R-C-2791	Iguratimod CAS:123663-49-0	Iguratimod is an antirheumatic agent,acts as an inhibitor of COX-2,with an IC50 of 20μM(7.7μg/mL),but shows no effect on COX-1.Iguratimod also inhibits macrophage migration inhibitory factor(MIF)with an IC50 of 6.81μM.	price>
R-R-4491	Epiblastin A CAS No.16470-02-3	Epiblastin A/CAS No.16470-02-3 is an ATP competitive casein kinase 1 (CK1) inhibitor with IC50s of 8.9, 0.5, and 4.7 µM for CK1α, CK1δ, and CK1 ɛ, respectively. Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of CK1.	price>
R-C-2792	TCN 238 CAS:125404-04-8	TCN238 is an orally bioavailable mGlu4 receptor positive allosteric modulator (PAM)with an EC50 of 1μM.	price>
R-C-3322	DSPE-PEG550-RGD(ARG-GLY-ASP)	Phospholipid polyethylene glycol RGD can be used for passive targeting,active targeting and drug delivery of micelles and vesicles.DSPE is a saturated 18 carbon phospholipid,which is commonly used in the synthesis of liposomes. Polyethylene glycol (PEG)-coupled DSPE is hydrophilic and can be used for drug delivery,gene transfection and biomolecular modification.PEGylation of phospholipid significantly improved the blood circulation time and stability of capsule drugs.Polyethylene glycol can enhance solubility and stability,reduce the surface nonspecific binding of charged molecules,and reduce the immunogenicity of peptides.	price>
R-R-4492	MRT00033659 CAS No.1401731-54-1	MRT00033659/CAS No.1401731-54-1 is a potent broad-spectrum kinase inhibitor of CK1 (IC50=0.9 µM for CK1δ) and CHK1 (IC50=0.23 µM). MRT00033659, a pyrazolo-pyridine analogue, induces p53 pathway activation and E2F-1 destabilisation.	price>
R-C-2793	RuBi-Nicotine CAS:1256362-30-7	Ruthenium-bisbipyridine-caged nicotine,excitable by irradiation with visible light.Undergoes rapid photolysis to release nicotine(<20 ns);exhibits a high quantum yield.Induces action potential propagation in Retzius neurons of leech ganglia with no detectable toxicity at a concentration of 1mM.	price>
R-C-3323	DSPE-PEG750-RGD(ARG-GLY-ASP)	Phospholipid polyethylene glycol RGD can be used for passive targeting,active targeting and drug delivery of micelles and vesicles.DSPE is a saturated 18 carbon phospholipid,which is commonly used in the synthesis of liposomes. Polyethylene glycol (PEG)-coupled DSPE is hydrophilic and can be used for drug delivery,gene transfection and biomolecular modification.PEGylation of phospholipid significantly improved the blood circulation time and stability of capsule drugs.Polyethylene glycol can enhance solubility and stability,reduce the surface nonspecific binding of charged molecules,and reduce the immunogenicity of peptides.	price>
R-R-4493	TMX-4113 CAS No.2766385-92-4	TMX-4113/CAS No.2766385-92-4 is a degrader of phosphodiesterase 6D (PDE6D) and casein kinase 1α (CK1α). TMX-4113 can be used for the research of cancer.	price>
R-C-2794	VU 0360223 CAS:1274859-33-4	Potent negative allosteric modulator of mGlu5(IC50=61nM).Displays no activity at mGlu1-4 and mGlu7-8.	price>
R-C-3324	DSPE-PEG350-BTC	In order to improve the accumulation of anticancer drugs in tumor and enhance the possibility of intracellular delivery,the stealth liposomes modified with arginine glycine aspartic acid (RGD) mimics were used as targeting vectors. Integrin was synthesized and covalently coupled with active polyethylene glycol phospholipid(DSPE-PEG-BTC) to form rgdm coupling compound (DSPE-PEG-RGDM).The binding of melanoma cells to dspe-peg-rgdm was studied by pH sensitive probe bcecf-am.	price>

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