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Catalog	name	Description	price
R-R-4265	Ladarixin sodium CAS No.865625-56-5	Ladarixin sodium (DF 2156A)/CAS No.865625-56-5 is an orally active, allosteric non-competitive and dual CXCR1 and CXCR2 antagonist. Ladarixin sodium can be used for the research of COPD and asthma.	price>
R-C-2566	IDF-11774 CAS:1429054-28-3	IDF-11774 is a hypoxia-inducible factor-1(HIF-1)inhibitor.It reduces the HRE-luciferase activity of HIF-1α(IC50=3.65μM)and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.	price>
R-R-4266	ATI-2341 TFA	ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs).	price>
R-R-4267	USL311 CAS No.1373268-67-7	USL311/CAS No.1373268-67-7 is a potent and selective CXCR4 antagonist, with anti-tumor activity. USL311 prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4.	price>
R-R-4268	CXCR2-IN-2 CAS No.1838123-21-9	CXCR2-IN-2/CAS No.1838123-21-9 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 μM.	price>
R-R-4269	Ulocuplumab CAS No.1375830-34-4	Ulocuplumab (Anti-Human CXCR4 Recombinant Antibody/BMS-936564/MDX1338)/CAS No.1375830-34-4 is a fully human IgG4 anti-CXCR4 antibody. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL). Ulocuplumab exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models.	price>
R-C-2570	Zotarolimus CAS:221877-54-9	Zotarolimus(ABT-578)is a derivative of rapamycin(HY-10219),with anti-proliferative activity.Zotarolimus is an immunosuppressant.Zotarolimus is developed specifically for local delivery from stents for the prevention of coronary artery restenosis.	price>
R-R-4270	SRT3190 CAS No.1204707-73-2	SRT3190/CAS No.1204707-73-2 is an antagonist of CXCR2, used in the research of chemokine mediated diseases.	price>
R-C-2571	Carmoisine CAS:154-93-8	Carmustine(bis-chloroethylnitrosourea,BCNU,BiCNU)is a cell-cycle phase nonspecific alkylating antineoplastic agent and used in the treatment of brain tumors and various other malignant neoplasms.	price>
R-R-4271	ALX 40-4C Trifluoroacetate	ALX 40-4C Trifluoroacetate is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC50 of 2.9 μM.	price>
R-C-2572	Metolazone CAS:17560-51-9	Metolazone(SR-720-22)is primarily used to treat congestive heart failure and high blood pressure.	price>
R-R-4272	CTCE-9908 CAS No.1030384-98-5	CTCE-9908/CAS No.1030384-98-5 is a potent and selective CXCR4 antagonist. CTCE-9908 induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells.	price>
R-C-2573	Delanzomib (CEP-18770) CAS:847499-27-8	Delanzomib(CEP-18770)is a potent and orally active chymotrypsin-like activity of the proteasome inhibitor with an IC50 of 3.8nM.Delanzomib inhibits NF-κB activity,induces cancer cell apoptotic,and has strong antiangiogenic and anti-cancer activities.	price>
R-R-4273	ACT-777991 CAS No.1967811-46-6	ACT-777991/CAS No.1967811-46-6 is an orally active and selective CXCR3 antagonist. ACT-777991 has microsomes and hepatocytes stability across animal models. ACT-777991 inhibits the migration of activated T cells toward CXCL11.	price>
R-C-2574	Trabectedin CAS:114899-77-3	Trabectedin(Ecteinascidin 743;ET-743)is a tetrahydroisoquinoline alkaloid with potent antitumor activity.Trabectedin binds to the minor groove of DNA,blocks transcription of stress-induced proteins,induces DNA backbone cleavage and cancer cells apoptosis,and increases the generation of ROS in MCF-7 and MDA-MB-453 cells.	price>
R-R-4274	CXCR7 modulator 1 CAS No.2231812-31-8	CXCR7 modulator 1 (compound 25)/CAS No.2231812-31-8 is a potent and orally bioavailable peptoid hybrid CXCR7 modulator, with a Ki of 9 nM.	price>
R-C-2575	Sabutoclax CAS:1228108-65-3	Sabutoclax(BI-97C1)is a potent a Mcl-1 Antagonist.Sabutoclax inhibits Tumorigenesis in Transgenic Mouse and Human Xenograft Models of Prostate Cancer. Sabutoclax(BI97C1)induce mitochondrial fragmentation either upstream of or independent of apoptosis.	price>
R-R-4275	(R,R)-CXCR2-IN-2 CAS No.1838123-22-0	(R,R)-CXCR2-IN-2/CAS No.1838123-22-0, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively.	price>
R-C-2576	NVP-CGM097 CAS:1313363-54-0	NVP-CGM097 is a highly potent and selective MDM2 inhibitor with Ki value of 1.3nM for hMDM2 in TR-FRET assay.It binds to the p53 binding-site of the Mdm2 protein,disrupting the interaction between both proteins,leading to an activation of the p53 pathway.	price>
R-R-4276	MSX-127 CAS No.6616-56-4	MSX-127/CAS No.6616-56-4 is a CXCR4 antagonist. MSX-127 inhibits cancer metastasis.	price>

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