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Catalog	name	Description	price
R-C-2392	Dronedarone CAS:141626-36-0	Dronedarone(SR33589)is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent.It shows rate-dependent inhibition of the rapid Na+ current,inhibits α and β-adrenergic receptors like Class II agents,exhibits blockade of K+ outward currents as the main mechanism of action of Class III, and effectively block slow Ca2+ inward currents(Class IV).	price>
R-R-4092	GW-405833 CAS No.180002-83-9	GW-405833 (L768242)/CAS No.180002-83-9 is a potent, selective cannabinoid receptor 2 (CB2) agonist with an EC50 of 50.7 nM. GW-405833 also behaves as a noncompetitive CB1 antagonist. GW-405833 suppresses inflammatory and neuropathic pain.	price>
R-C-2393	Pimozide CAS:2062-78-4	Pimozide(Orap,R6238)is an antagonist of Dopamine Receptors with Ki of 0.83nM,3.0 nM and 6600nM for dopamine D3,D2 and D1 receptors, respectively.Pimozide also exhibits binding affinity at α2-adrenoceptor and 5-HT1A with Ki of 360nM and 310nM,respectively.Pimozide is an antipsychotic drug with anti-tumor activity and suppresses STAT3 and STAT5 activity.	price>
R-R-4093	Leelamine hydrochloride CAS No.16496-99-4	Leelamine hydrochloride/CAS No.16496-99-4 is a tricyclic diterpene molecule that is extracted from the bark of pine trees. Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor, which is known to regulate fatty acid synthesis[2,3].	price>
R-C-2394	Alfuzosin HCl CAS:81403-68-1	Alfuzosin HCl is a pharmaceutical drug of the alpha-1 blocker class.As an antagonist of the alpha-1 adrenergic receptor,it works by relaxing the muscles in the prostate and bladder neck,making it easier to urinate.It is thus used to treat benign prostatic hyperplasia(BPH).	price>
R-R-4094	MDA 19 CAS No.1048973-47-2	MDA 19/CAS No.1048973-47-2 is a potent and selective agonist of human cannabinoid receptor 2 (CB2), with a Ki of 43.3 nM. MDA 19 has antiallodynic effects in a rat model of neuropathic pain and does not affect rat locomotor activity.	price>
R-C-2395	Silodosin CAS:160970-54-7	Silodosin(KAD 3213;KMD 3213)is a potent,selective and orally active α1A-adrenergic receptor(α1A-AR)blocker.Silodosin is an effective and well-tolerated agent,it can be used for the investigation of LUTS/BPH.	price>
R-R-4095	Virodhamine CAS No.287937-12-6	Virodhamine/CAS No.287937-12-6 is an endocannabinoid, it regulates neurotransmission by activating the cannabinoid (CB) receptors. Virodhamine is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine induces megakaryocytic differentiation by triggering MAPK signaling and ROS production.	price>
R-C-2396	Nebivolol hydrochloride (R-65824) CAS:152520-56-4	Nebivolol hydrochloride selectively inhibits β1- adrenergic receptor with IC50 of 0.8nM.	price>
R-R-4096	Etrinabdione CAS No.1818428-24-8	Etrinabdione (EHP-101; VCE-004.8)/CAS No.1818428-24-8 is an orally active, specific PPARγ and CB2 receptor dual agonist. Etrinabdione inhibits prolyl-hydroxylases (PHDs) and activates the HIF pathway. Etrinabdione, a semi-synthetic multitarget cannabinoquinoid, has potent anti-inflammatory activity. Etrinabdione attenuates adipogenesis and prevents diet-induced obesity.	price>
R-C-2397	BMY 7378 Dihydrochloride CAS:21102-95-4	BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2,respectively,and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3.	price>
R-R-4097	CB1 antagonist 2 CAS No.614726-85-1	CB1 antagonist 2/CAS No.614726-85-1 is caimabinoid 1 (CB1) antagonist extracted from patent WO2016184310A1, compound 3, inhibits CB1 in vivo with an IC50 of 25.5 nM.	price>
R-C-2398	Prazosin HCl CAS:19237-84-4	Prazosin hydrochloride is a well-tolerated,CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders. Prazosin hydrochloride potently inhibits Norepinephrine(NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM.Prazosin hydrochloride inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8, and 13μM,respectively.	price>
R-R-4098	Tedalinab CAS No.916591-01-0	Tedalinab (GRC-10693)/CAS No.916591-01-0 is a potent, orally active, and selective cannabinoid receptor 2 (CB2) agonist. Tedalinab has >4700-fold functional selectivity for CB2 over CB1. Tedalinab has potential for neuropathic pain and osteoarthritis treatment.	price>
R-C-2399	Naftopidil CAS:57149-07-2	Naftopidil(KT-611)is is a selective alpha1-adrenoceptor antagonist,with Kis of 3.7nM,20nM and 1.2nM for the cloned human α1a-,α1b-and α1d-adrenoceptor subtypes,respectively.Naftopidil has antiproliferative effects.Naftopidil can be used for the research of prostate hyperplasia.	price>
R-R-4099	Pregnenolone-d4-1 CAS No.61574-54-7	Pregnenolone-d4-1/CAS No.61574-54-7 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.	price>
R-C-2400	Timolol Maleate CAS:26921-17-5	(S)-Timolol Maleate(L-714,465 Maleate)is a non-cardioselective hydrophilic β-adrenoceptor blocker.(S)-Timolol Maleate is widely used as standard medication for intraocular pressure(glaucoma)by preventing the production of aqueous humor. (S)-Timolol Maleate can be used for hypertension,angina pectoris and myocardial infarction.	price>
R-R-4100	GAT211 CAS No.102704-40-5	GAT211/CAS No.102704-40-5 is a cannabinoid 1 receptor (CB1R) positive allosteric modulator (PAM). GAT211 activates cAMP and β-arrestin2 with EC50 values of 260 nM and 650 nM, respectively. GAT211 inhibits GAT211 can be used for neuropathic and/or inflammatory pain research.	price>
R-C-2401	Fargesin CAS:31008-19-2	Fargesin is a lignan from Magnolia fargesii,an oriental medicine used in the treatment of nasal congestion and sinusitis.Fargesin exhibits anti-inflammation effects on THP-1 cells via suppression of PKC pathway including downstream JNK, nuclear factors AP-1 and NF-ĸB.	price>
R-R-4101	CB2R PAM CAS No.2244579-87-9	CB2R PAM/CAS No.2244579-87-9 is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain.	price>

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