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Catalog	name	Description	price
R-C-1531	Binimetinib (MEK-162, ARRY-162, ARRY-438162)	Binimetinib(MEK162)is an oral and selective MEK1/2 inhibitor.Binimetinib (MEK162)inhibits MEK with an IC50 of 12 nM.	price>
R-R-3231	SB-203186 hydrochloride CAS No.207572-69-8	SB-203186 hydrochloride/CAS No.207572-69-8 is a potent, selective and competitive 5-HT4 antagonist. SB-203186 hydrochloride antagonizes the 5-HT4 receptor-mediated relaxations of the carbachol-contracted rat isolated oesophagus against 5-HT with pKB values of 10.9 (rat oesophagus), 9.5 (guinea-pig ileum), and 9.0 (human colon) respectively.	price>
R-C-1532	Galeterone CAS:851983-85-2	Galeterone(TOK-001)is a selective CYP17 inhibitor and androgen receptor (AR)antagonist with IC50 of 300 nM and 384 nM,respectively,and is a potent inhibitor of human prostate tumor growth.	price>
R-R-3232	VUF10166 CAS No.155584-74-0	VUF10166/CAS No.155584-74-0 is a potent and high-affinity 5-HT3 receptor antagonist, with Ki values of 0.04 nM (5-HT3A) and 22 nM (5-HT3AB). VUF10166 inhibits 5-HT-induced responses at 5-HT3A and 5-HT3AB receptors at nanomolar concentrations. At 5-HT3 receptor, VUF10166 at higher concentrations also acts as a partial agonist, with an EC50 of 5.2 μM.	price>
R-C-1533	GSK163090 CAS:844903-58-8	GSK163090 is a potent,selective and orally active 5-HT1A/1B/1D receptor antagonist with pKi values of 9.4/8.5/9.7,respectively. GSK163090 inhibits the functional activity of serotonin reuptake transporter(SerT)with a pKi value of 6.1.GSK163090 has antidepressant and anxiolytic activities.	price>
R-R-3233	SB-399885 hydrochloride CAS No.402713-81-9	SB-399885 hydrochloride/CAS No.402713-81-9 is a 5-HT6 receptor antagonist.	price>
R-C-1534	AMG319 CAS : 1608125-21-8	AMG-319(ACP319)is a highly selective,potent,and orally bioavailable small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases(PI3K)with potential immunomodulating and antineoplastic activities.PI3K-delta inhibitor AMG 319 prevents the activation of the PI3K signaling pathway through inhibition of the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate(PIP3),thus decreasing proliferation and inducing cell death.	price>
R-R-3234	BMY-14802 hydrochloride CAS No.105565-55-7	BMY-14802 hydrochloride (BMY-14802-1)/CAS No.105565-55-7 is a selective and orally active sigma receptor antagonist with an IC50 of 112 nM. BMY-14802 hydrochloride is also a 5-HT1A and adrenergic α1 receptors agonist. BMY-14802 hydrochloride has antipsychotic effects.	price>
R-C-1535	Vipadenant(BIIB 014) CAS:442908-10-3	Vipadenant,also known as BIIB014,CEB-4520,is a potent,selective and orally available adenosine A2A receptor antagonist under development for Parkinson is disease.Vipadenant demonstrates strong oral activity in commonly used models of Parkinson is disease.	price>
R-R-3235	CP-809101 hydrochloride CAS No.1215721-40-6	CP-809101 hydrochloride/CAS No.1215721-40-6 is a potent and highly selective 5-HT2C receptor agonist, with pEC50s of 9.96, 7.19 and 6.81 M for human 5HT2C, 5HT2B and 5HT2A receptor. CP-809101 hydrochloride inhibits conditioned avoidance responding in rats and antagonizes both PCP (phencyclidine hydrochloride)- and d-amphetamine-induced hyperactivity. CP-809101 hydrochloride also reduces food and nicotine dependence in rats, can be used in studies of antipsychotic and nicotine dependence.	price>
R-C-1536	UNC2025 CAS:1429881-91-3	UNC2025 is a potent,ATP-competitive and highly orally active Mer/Flt3 inhibitor with IC50 values of 0.74 nM and 0.8 nM, respectively.UNC2025 is>45-fold selectivity for MERTK relative to Axl(IC50=122 nM;Ki=13.3 nM).UNC2025 exhibits an excellent PK properties,and can be used for the investigation of acute leukemia.	price>
R-R-3236	Ramosetron Hydrochloride CAS No.132907-72-3	Ramosetron Hydrochloride(YM060 Hydrochloride)/CAS No.132907-72-3 is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting.	price>
R-C-1537	Irbinitinib (ARRY-380) CAS:937263-43-9	Tucatinib(Irbinitinib,ONT-380,ARRY-380)is an oral,potent,selective,reversible and ATP-competitive small-molecule inhibitor of ErbB-2(also called HER2)with IC50s of 8 nM and 7 nM for ErbB-2 and p95 HER2,respectively in cell-based assays,showing ~500-fold selective for HER2 vs EGFR.It has potential antineoplastic activity.	price>
R-R-3237	Idalopirdine Hydrochloride CAS No.467458-02-2	Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride)/CAS No.467458-02-2 is a potent, selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM. Idalopirdine Hydrochloride may be used in studies of schizophrenia, among other related disorders.	price>
R-C-1538	CEP-33779 CAS:1257704-57-6	CEP-33779 is a highly selective,orally active,small-molecule inhibitor of JAK2. CEP-33779 induced regression of established colorectal tumors,rRadotinib educed angiogenesis,and reduced proliferation of tumor cells.Tumor regression correlated with inhibition of STAT3 and NF-κB(RelA/p65)activation in a CEP-33779 dose-dependent manner.The ability of CEP-33779 to suppress growth of colorectal tumors by inhibiting the IL-6/JAK2/STAT3 signaling suggests a potential therapeutic utility of JAK2 inhibitors in multiple tumors types, particularly those with a strong inflammatory component.	price>
R-R-3238	cis-Urocanic acid CAS No.7699-35-6	cis-Urocanic acid/CAS No.7699-35-6 is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.	price>
R-C-1539	Liproxstatin-1 CAS: 950455-15-9	Liproxstatin-1 is a potent inhibitor of ferroptosis,a non-apoptotic form of cell death characterized by iron-dependent accumulation of lethal lipid reactive oxygen species(ROS).Ferroptosis is a non-apoptotic form of cell death induced by small molecules in specific tumour types,and in engineered cells overexpressing oncogenic RAS.	price>
R-R-3239	Cinanserin hydrochloride CAS No.54-84-2	Cinanserin hydrochloride (SQ 10643)/CAS No.54-84-2 is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro.	price>
R-C-1540	TPCA-1 CAS:507475-17-4	TPCA-1 is a potent and selective inhibitor of IKK-2 with IC50 of 17.9 nM. TPCA-1 is an effective inhibitor of STAT3 phosphorylation,DNA binding,and transactivation.	price>
R-R-3240	Masupirdine mesylate CAS No.1791396-46-7	Masupirdine mesylate (SUVN-502 mesylate)/CAS No.1791396-46-7 is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites.	price>

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