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Catalog	name	Description	price
R-R-3275	Pipamperone CAS No.1893-33-0	Pipamperone (Floropipamide; McN-JR 3345; R 3345)/CAS No.1893-33-0 is a high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0) and a low-affinity antagonist of D2 receptor (pKi=6.7).	price>
R-C-1576	VX497（Merimepodib） CAS：198821-22-6	Merimepodib(Merimempodib,MMPD,VI-21,497,VX-497)is a potent,specific,and reversible inosine monophosphate dehydrogenase(IMPDH)inhibitor with antiviral activity against hepatitis C virus(HCV)and a variety of DNA and RNA viruses in vitro.Merimepodib is an immunosuppressive agent.	price>
R-R-3276	Org-12962 CAS No.132834-56-1	Org-12962/CAS No.132834-56-1 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively.Org-12962 displays antiaversive effects in a rat model of panic-like anxiety.	price>
R-C-1577	FLLL32 CAS:1226895-15-3	FLLL32,a synthetic analog of curcumina,is a JAK2/STAT3 dual inhibitor with anti-tumor activity.FLLL32 can inhibit the induction of STAT3 phosphorylation by IFNα and IL-6 in breast cancer cells.	price>
R-R-3277	Spiroxatrine CAS No.1054-88-2	Spiroxatrine (R 5188)/CAS No.1054-88-2 is a selective, dual antagonist of 5-HT1α and α2-adrenergic, with the Ki values of 3.94, 224000, 118.5 nM for 5-HT1α, 5-HT1β and 5-HT2, respectively. Spiroxatrine (R 5188) has a sedative effect.	price>
R-C-1578	JK184 CAS:315703-52-7	JK-184 is a potent downstream hedgehog(Hh)signaling inhibitor that prevents Gli-dependent transcriptional activity(IC50=30nM).JK184 can specially inhibit Gli in the Hedgehog(Hh)pathway,which showed great promise for cancer therapeutics.	price>
R-R-3278	LY-272015 hydrochloride CAS No.172895-15-7	LY-272015 hydrochloride/CAS No.172895-15-7 is an orally active, specific 5-HT2B receptor antagonist. LY-272015 hydrochloride completely inhibits the phosphorylation of ERK2 induced by 5-HT or BW723C86. LY-272015 hydrochloride is antihypertensive in Deoxycorticosterone Acetate (DOCA)-salt-hypertensive rats.	price>
R-C-1579	VU0364770 CAS:61350-00-3	VU 0364770 is a positive allosteric modulator(PAM)of mGlu4 with EC50 of 1.1 μM,exhibits insignificant activity at 68 other receptors,including other mGlu subtypes.	price>
R-R-3279	(E)-3,4,5-Trimethoxycinnamic acid CAS No.20329-98-0	(E)-3,4,5-Trimethoxycinnamic acid (TMCA)/CAS No.20329-98-0 is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy.	price>
R-C-1580	VU0361737 CAS:1161205-04-4	VU 0361737 is a selective positive allosteric modulator(PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors,respectively,displays weak activity at mGlu5 and mGlu8 receptors,is inactive at mGlu1,mGlu2,mGlu3,mGlu6 and mGlu7 receptors,can penetrate into CNS.	price>
R-R-3280	YM348 CAS No.372163-84-3	YM348/CAS No.372163-84-3 is a potent and orally active 5-HT2C receptor agonist, which shows a high affinity for cloned human 5-HT2C receptor (Ki: 0.89 nM).	price>
R-R-3281	ST1936 CAS No.1210-81-7	ST1936/CAS No.1210-81-7 is a selective, nanomolar affinity 5-HT6 receptor agonist with Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively. ST1936 also shows moderate affinity (Ki of 300 nM) for human and rat α2 adrenergic receptor.	price>
R-C-1581	NU7026 CAS:154447-35-5	NU7026(LY293646)is a potent DNA-PK inhibitor with IC50 of 0.23 μM in cell-free assays,60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR.NU7026 enhances G2/M cell arrest and apoptosis.	price>
R-C-1582	Motolimod (VTX-2337) CAS:926927-61-9	Motolimod(VTX-2337)is a selective and potent Toll-like receptor 8(TLR8)agonist with EC50 of 100 nM,>50-fold selectivity over TLR7.	price>
R-R-3282	(S)-Mirtazapine CAS No.61337-87-9	(S)-Mirtazapine ((S)-Org3770)/CAS No.61337-87-9 is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception. (S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2.	price>
R-C-1583	Alvespimycin	Alvespimycin is a heat shock protein 90(Hsp90)inhibitor and promising therapeutic agent for cancer.	price>
R-R-3283	Repinotan hydrochloride CAS No.144980-77-8	Repinotan hydrochloride (BAY x 3702)/CAS No.144980-77-8 is a potent, selective, brain-penetrant and orally active 5-HT1A receptor agonist, with Ki values of 0.19 nM (calf hippocampus), 0.25 nM (rat and human cortex), and 0.59 nM (rat hippocampus Repinotan hydrochloride has a weak affinity for other related receptors. Repinotan hydrochloride has pronounced neuroprotective effects.	price>
R-C-1584	GRT6005(Cebranopadol) CAS:863513-91-1	Cebranopadol(GRT-6005)is a Opioid Receptor Agonist with agonistic activity at nociceptin/orphanin FQ and opioid receptors.Cebranopadol displays analgesic, antiallodynic and antihyperalgesic properties in several rat models of acute nociceptive,inflammatory,cancer and neuropathic pain.In contrast to classical opioids,it has a higher analgesic potency in models of neuropathic pain than in acute nociceptive pain.Even at higher analgesic doses,cebranopadol does not induce motor coordination deficits or respiratory depression in rats.	price>
R-R-3284	Clothiapine CAS No.2058-52-8	Clothiapine/CAS No.2058-52-8, an atypical antipsychotic agent, shares with clozapine its strong antiserotonergic properties.	price>
R-C-1585	VR23 CAS : 1624602-30-7	VR23 is a small molecule that potently inhibited the activities of trypsin-like proteasomes(IC50=1nM),chymotrypsin-like proteasomes(IC50=50-100nM),and caspase-like proteasomes(IC50=3uM).	price>

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